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3EKL
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STRUCTURAL CHARACTERIZATION OF TETRAMERIC MYCOBACTERIUM TUBERCULOSIS FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE - SUBSTRATE BINDING AND CATALYSIS MECHANISM OF A CLASS IIA BACTERIAL ALDOLASE
分子名称:Fructose-bisphosphate aldolase, 1,3-DIHYDROXYACETONEPHOSPHATE, ZINC ION, ...
著者Pegan, S., Rukseree, K., Franzblau, S.G., Mesecar, A.D.
登録日2008-09-19
公開日2009-02-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis
J.Mol.Biol., 386, 2009
3EKZ
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STRUCTURAL CHARACTERIZATION OF TETRAMERIC MYCOBACTERIUM TUBERCULOSIS FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE - SUBSTRATE BINDING AND CATALYSIS MECHANISM OF A CLASS IIA BACTERIAL ALDOLASE
分子名称:Fructose-bisphosphate aldolase, 1,3-DIHYDROXYACETONEPHOSPHATE, SN-GLYCEROL-3-PHOSPHATE, ...
著者Pegan, S., Rukseree, K., Franzblau, S.G., Mesecar, A.D.
登録日2008-09-19
公開日2009-02-10
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis
J.Mol.Biol., 386, 2009
3ELF
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STRUCTURAL CHARACTERIZATION OF TETRAMERIC MYCOBACTERIUM TUBERCULOSIS FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE - SUBSTRATE BINDING AND CATALYSIS MECHANISM OF A CLASS IIA BACTERIAL ALDOLASE
分子名称:Fructose-bisphosphate aldolase, 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM), SODIUM ION, ...
著者Pegan, S., Rukseree, K., Franzblau, S.G., Mesecar, A.D.
登録日2008-09-22
公開日2009-02-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis
J.Mol.Biol., 386, 2009
5AGR
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, LEUCINE, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGS
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-09
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGT
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-4-CHLORO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
3PKA
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M. TUBERCULOSIS METAP WITH BENGAMIDE ANALOG Y02, IN MN FORM
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, (2R,3R,4S,5R,6E)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-N-[2-(2,4,6-trimethylphenoxy)ethyl]non-6-enamide, ...
著者Ye, Q.Z., Lu, J.P.
登録日2010-11-11
公開日2011-04-20
最終更新日2013-05-29
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
3PKB
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M. TUBERCULOSIS METAP WITH BENGAMIDE ANALOG Y16, IN MN FORM
分子名称:Methionine aminopeptidase, (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, ...
著者Ye, Q.Z., Lu, J.P.
登録日2010-11-11
公開日2011-04-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
3PKC
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M. TUBERCULOSIS METAP WITH BENGAMIDE ANALOG Y08, IN MN FORM
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide
著者Ye, Q.Z., Lu, J.P.
登録日2010-11-11
公開日2011-04-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
3PKD
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M. TUBERCULOSIS METAP WITH BENGAMIDE ANALOG Y10, IN MN FORM
分子名称:Methionine aminopeptidase, MANGANESE (II) ION, (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide
著者Ye, Q.Z., Lu, J.P.
登録日2010-11-11
公開日2011-04-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
3PKE
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M. TUBERCULOSIS METAP WITH BENGAMIDE ANALOG Y10, IN NI FORM
分子名称:Methionine aminopeptidase, (E,2R,3R,4S,5R)-N-(2,3-dihydro-1H-inden-2-yl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, NICKEL (II) ION, ...
著者Ye, Q.Z., Lu, J.P.
登録日2010-11-11
公開日2011-04-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
Chemmedchem, 6, 2011
4DEF
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ACTIVE SITE LOOP DYNAMICS OF A CLASS IIA FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM M. TUBERCULOSIS
分子名称:Fructose-bisphosphate aldolase, ZINC ION, SODIUM ION, ...
著者Capodagli, G.C., Pegan, S.D.
登録日2012-01-20
公開日2013-01-23
最終更新日2013-06-26
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
Biochemistry, 52, 2013
4DEL
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ACTIVE SITE LOOP DYNAMICS OF A CLASS IIA FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM M. TUBERCULOSIS
分子名称:Fructose-bisphosphate aldolase, SODIUM ION, ZINC ION, ...
著者Pegan, S.D., Mesecar, A.D.
登録日2012-01-20
公開日2013-01-23
最終更新日2013-06-26
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
Biochemistry, 52, 2013
4FX0
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS TRANSCRIPTIONAL REGULATOR MOSR
分子名称:PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN
著者Brugarolas, P., He, C.
登録日2012-07-02
公開日2012-09-26
最終更新日2012-11-21
実験手法X-RAY DIFFRACTION (2.6981 Å)
主引用文献The Oxidation-sensing Regulator (MosR) Is a New Redox-dependent Transcription Factor in Mycobacterium tuberculosis.
J.Biol.Chem., 287, 2012
4FX4
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS TRANSCRIPTIONAL REGULATOR MOSR (RV1049) IN COMPEX WITH DNA
分子名称:DNA (5'-D(*TP*AP*CP*AP*GP*AP*TP*TP*CP*GP*TP*GP*TP*AP*GP*CP*TP*AP*CP*AP*CP*GP*AP*AP*TP*CP*TP*GP*T)-3'), PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN, PHOSPHATE ION
著者Brugarolas, P., He, C.
登録日2012-07-02
公開日2012-09-26
最終更新日2012-11-21
実験手法X-RAY DIFFRACTION (3.1001 Å)
主引用文献The Oxidation-sensing Regulator (MosR) Is a New Redox-dependent Transcription Factor in Mycobacterium tuberculosis.
J.Biol.Chem., 287, 2012
5OEL
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MYCOBACTERIUM TUBERCULOSIS DPRE1 MUTANT Y314C IN COMPLEX WITH TCA1
分子名称:Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]thiophen-3-yl}carbonyl)carbamate
著者Futterer, K., Batt, S.M., Besra, G.S.
登録日2017-07-08
公開日2018-05-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OEP
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MYCOBACTERIUM TUBERCULOSIS DPRE1 IN COMPLEX WITH INHIBITOR TCA481
分子名称:Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ~{N}-[2-(1,3-benzothiazol-2-ylcarbonylamino)-5-fluoranyl-thiophen-3-yl]carbonylcarbamate, ...
著者Futterer, K., Batt, S.M., Besra, G.S.
登録日2017-07-09
公開日2018-05-16
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OEQ
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MYCOBACTERIUM TUBERCULOSIS DPRE1 IN COMPLEX WITH INHIBITOR TCA020
分子名称:Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-[3-(pyrimidin-2-ylcarbamoyl)thiophen-2-yl]-[1,3]thiazolo[4,5-c]pyridine-2-carboxamide, ...
著者Futterer, K., Batt, S.M., Besra, G.S.
登録日2017-07-09
公開日2018-05-16
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5W0C
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CYTOCHROME P450 (CYP) 2C9 TCA007 INHIBITOR COMPLEX
分子名称:Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, ethyl {2-[([1,3]thiazolo[4,5-c]pyridine-2-carbonyl)amino]thiophene-3-carbonyl}carbamate, ...
著者Johnson, E.F., Hsu, M.-H.
登録日2017-05-30
公開日2017-09-13
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017