Author results

1IGL
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SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS
Descriptor:INSULIN-LIKE GROWTH FACTOR II
Authors:Torres, A.M., Forbes, B.E., Aplin, S.E., Wallace, J.C., Francis, G.L., Norton, R.S.
Deposit date:1994-12-29
Release date:1995-02-14
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions.
J.Mol.Biol., 248, 1995
1Y8Y
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CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A PYRAZOLO[1,5-A]PYRIMIDINE INHIBITOR
Descriptor:Cell division protein kinase 2, (5-CHLOROPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-(4-METHANESULFONYLPHENYL)AMINE
Authors:Williamson, D.S., Parratt, M.J., Torrance, C.J., Bower, J.F., Moore, J.D., Richardson, C.M., Dokurno, P., Cansfield, A.D., Francis, G.L., Hebdon, R.J., Howes, R., Jackson, P.S., Lockie, A.M., Murray, J.B., Nunns, C.L., Powles, J., Robertson, A., Surgenor, A.E.
Deposit date:2004-12-14
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Bioorg.Med.Chem.Lett., 15, 2005
1Y91
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CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A PYRAZOLO[1,5-A]PYRIMIDINE INHIBITOR
Descriptor:Cell division protein kinase 2, 4-[5-(TRANS-4-AMINOCYCLOHEXYLAMINO)-3-ISOPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YLAMINO]-N,N-DIMETHYLBENZENESULFONAMIDE
Authors:Williamson, D.S., Parratt, M.J., Torrance, C.J., Bower, J.F., Moore, J.D., Richardson, C.M., Dokurno, P., Cansfield, A.D., Francis, G.L., Hebdon, R.J., Howes, R., Jackson, P.S., Lockie, A.M., Murray, J.B., Nunns, C.L., Powles, J., Robertson, A., Surgenor, A.E.
Deposit date:2004-12-14
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Bioorg.Med.Chem.Lett., 15, 2005
3LRI
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SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF LONG-[ARG(3)]INSULIN-LIKE GROWTH FACTOR-I
Descriptor:PROTEIN (INSULIN-LIKE GROWTH FACTOR I)
Authors:Laajoki, L.G., Francis, G.L., Wallace, J.C., Carver, J.A., Keniry, M.A.
Deposit date:1999-04-13
Release date:2000-05-23
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I
J.Biol.Chem., 275, 2000
2C68
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-08
Release date:2005-12-07
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
2C69
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-08
Release date:2005-12-07
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Bioorg. Med. Chem. Lett., 16, 2006
2C6I
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, 4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-10
Release date:2005-12-07
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
2C6K
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-10
Release date:2005-12-07
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
2C6L
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-10
Release date:2005-12-07
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
2C6M
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-10
Release date:2005-12-07
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
2C6O
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-10
Release date:2005-12-07
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Bioorg. Med. Chem. Lett., 16, 2006
2C6T
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
Authors:Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Deposit date:2005-11-11
Release date:2005-12-07
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar.
Bioorg.Med.Chem.Lett., 16, 2006
3FZF
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CRYSTAL STRUCTURE OF HSC70/BAG1 IN COMPLEX WITH ATP
Descriptor:Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Dokurno, P., Williamson, D.S., Murray, J.B., Surgenor, A.E.
Deposit date:2009-01-26
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design
J.Med.Chem., 52, 2009
3FZH
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CRYSTAL STRUCTURES OF HSC70/BAG1 IN COMPLEX WITH SMALL MOLECULE INHIBITORS
Descriptor:Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Authors:Dokurno, P., Williamson, D.S., Murray, J.B., Surgenor, A.E.
Deposit date:2009-01-26
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design
J.Med.Chem., 52, 2009
3FZK
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CRYSTAL STRUCTURES OF HSC70/BAG1 IN COMPLEX WITH SMALL MOLECULE INHIBITORS
Descriptor:Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Dokurno, P., Williamson, D.S., Murray, J.B., Surgenor, A.E.
Deposit date:2009-01-26
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design
J.Med.Chem., 52, 2009
3FZL
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CRYSTAL STRUCTURES OF HSC70/BAG1 IN COMPLEX WITH SMALL MOLECULE INHIBITORS
Descriptor:Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Dokurno, P., Williamson, D.S., Murray, J.B., Surgenor, A.E.
Deposit date:2009-01-26
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design
J.Med.Chem., 52, 2009
3FZM
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CRYSTAL STRUCTURES OF HSC70/BAG1 IN COMPLEX WITH SMALL MOLECULE INHIBITORS
Descriptor:Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-(quinolin-6-ylmethylamino)purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile
Authors:Dokurno, P., Williamson, D.S., Murray, J.B., Surgenor, A.E.
Deposit date:2009-01-26
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design
J.Med.Chem., 52, 2009
3LDL
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CRYSTAL STRUCTURE OF HUMAN GRP78 (70KDA HEAT SHOCK PROTEIN 5 / BIP) ATPASE DOMAIN IN COMPLEX WITH ATP
Descriptor:78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.
Deposit date:2010-01-13
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
J.Med.Chem., 54, 2011
3LDN
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CRYSTAL STRUCTURE OF HUMAN GRP78 (70KDA HEAT SHOCK PROTEIN 5 / BIP) ATPASE DOMAIN IN APO FORM
Descriptor:78 kDa glucose-regulated protein
Authors:Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.
Deposit date:2010-01-13
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
J.Med.Chem., 54, 2011
3LDO
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CRYSTAL STRUCTURE OF HUMAN GRP78 (70KDA HEAT SHOCK PROTEIN 5 / BIP) ATPASE DOMAIN IN COMPLEX WITH AMPPNP
Descriptor:78 kDa glucose-regulated protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.
Deposit date:2010-01-13
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
J.Med.Chem., 54, 2011
3LDP
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CRYSTAL STRUCTURE OF HUMAN GRP78 (70KDA HEAT SHOCK PROTEIN 5 / BIP) ATPASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:78 kDa glucose-regulated protein, 8-[(quinolin-2-ylmethyl)amino]adenosine
Authors:Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.
Deposit date:2010-01-13
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
J.Med.Chem., 54, 2011
3LDQ
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CRYSTAL STRUCTURE OF HSC70/BAG1 IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, 8-[(quinolin-2-ylmethyl)amino]adenosine
Authors:Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.
Deposit date:2010-01-13
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
J.Med.Chem., 54, 2011
3M3Z
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CRYSTAL STRUCTURE OF HSC70/BAG1 IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, 5'-O-(2-amino-2-oxoethyl)-8-(methylamino)adenosine
Authors:Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.
Deposit date:2010-03-10
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
J.Med.Chem., 54, 2011