Author results

3FA2
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CRYSTAL STRUCTURE OF THE BRCA1 ASSOCIATED RING DOMAIN (BARD1) TANDEM BRCT DOMAINS
Descriptor:BRCA1-associated RING domain protein 1, PHOSPHATE ION, GLYCEROL
Authors:Fox III, D., Le Trong, I., Stenkamp, R.E., Klevit, R.E.
Deposit date:2008-11-14
Release date:2008-12-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains
TO BE PUBLISHED
4E44
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CRYSTAL STRUCTURE OF THE HMHF1/HMHF2 HISTONE-FOLD TETRAMER
Descriptor:Centromere protein S, Centromere protein X
Authors:Fox III, D., Zhao, Y., Yang, W., Weidong, W.
Deposit date:2012-03-12
Release date:2013-03-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
To be Published
4E45
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CRYSTAL STRUCTURE OF THE HMHF1/HMHF2 HISTONE-FOLD TETRAMER IN COMPLEX WITH FANCONI ANEMIA ASSOCIATED HELICASE HFANCM
Descriptor:Centromere protein S, Centromere protein X, Fanconi anemia group M protein, ...
Authors:Fox III, D., Zhao, Y., Yang, W., Weidong, W.
Deposit date:2012-03-12
Release date:2013-03-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
To be Published
5KLX
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CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF110
Descriptor:Chimera protein of Ubiquitin-like protein SMT3 and Peptidyl-prolyl cis-trans isomerase, 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate, MAGNESIUM ION, ...
Authors:Fox III, D., Edwards, T.E.
Deposit date:2016-06-26
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110
To Be Published
6NJH
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN AND UCR2 REGULATORY HELIX WITH T-48
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Fox III, D., Fairman, J.W., Gurney, M.E.
Deposit date:2019-01-03
Release date:2019-05-08
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
J.Med.Chem., 62, 2019
6NJI
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN AND UCR2 REGULATORY HELIX WITH T-49
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Fox III, D., Fairman, J.W., Gurney, M.E.
Deposit date:2019-01-03
Release date:2019-05-08
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
J.Med.Chem., 62, 2019
5B8I
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CRYSTAL STRUCTURE OF CALCINEURIN A AND CALCINEURIN B IN COMPLEX WITH FKBP12 AND FK506 FROM COCCIDIOIDES IMMITIS RS
Descriptor:Serine/threonine-protein phosphatase, Calcineurin subunit B, variant, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D., Dranow, D.M., Lorimer, D.D., Edwards, T.E.
Deposit date:2015-05-03
Release date:2015-05-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS
TO BE PUBLISHED
5IFI
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CRYSTAL STRUCTURE OF ACETYL-COA SYNTHETASE IN COMPLEX WITH ADENOSINE-5'-PROPYLPHOSPHATE FROM CRYPTOCOCCUS NEOFORMANS H99
Descriptor:Acetyl-coenzyme A synthetase, ADENOSINE-5'-MONOPHOSPHATE-PROPYL ESTER, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID), SSGCID, Fox III, D., Edwards, T.E., Lorimer, D.D., Mutz, M.W.
Deposit date:2016-02-26
Release date:2016-03-16
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of Acetyl-CoA Synthetase in complex with Adenosine-5'-propylphosphate from Cryptococcus neoformans H99
To Be Published
5K85
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CRYSTAL STRUCTURE OF ACETYL-COA SYNTHETASE IN COMPLEX WITH ADENOSINE-5'-PROPYLPHOSPHATE AND COENZYME A FROM CRYPTOCOCCUS NEOFORMANS H99
Descriptor:Acetyl-coenzyme A synthetase, ADENOSINE-5'-MONOPHOSPHATE-PROPYL ESTER, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D., Delker, S.L., Potts, K.T., Lorimer, D.D., Edwards, T.E., Mutz, M.W., SSGCID
Deposit date:2016-05-27
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CRYSTAL STRUCTURE OF ACETYL-COA SYNTHETASE IN COMPLEX WITH ADENOSINE-5'-PROPYLPHOSPHATE AND COENZYME A FROM CRYPTOCOCCUS NEOFORMANS H99
To Be Published
5K8F
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CRYSTAL STRUCTURE OF ACETYL-COA SYNTHETASE IN COMPLEX WITH ATP AND ACETYL-AMP FROM CRYPTOCOCCUS NEOFORMANS H99
Descriptor:Acetyl-coenzyme A synthetase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D., Delker, S.L., Potts, K.T., Lorimer, D.D., Edwards, T.E., Mutz, M.W., SSGCID
Deposit date:2016-05-30
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of Acetyl-CoA Synthetase in complex with ATP and Acetyl-AMP from Cryptococcus neoformans H99
To Be Published
5U29
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CRYSTAL STRUCTURE OF CRYPTOCOCCUS NEOFORMANS H99 ACETYL-COA SYNTHETASE IN COMPLEX WITH AC-AMS
Descriptor:Acetyl-coenzyme A synthetase, 5'-O-(acetylsulfamoyl)adenosine, PHOSPHATE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D., Edwards, T.E., Potts, K.T., Taylor, B.M.
Deposit date:2016-11-30
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Cryptococcus neoformans H99 Acetyl-CoA Synthetase in complex with Ac-AMS
To Be Published
5U2A
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CRYSTAL STRUCTURE OF BRUCELLA CANIS ACYL-COA SYNTHETASE
Descriptor:AMP-dependent synthetase and ligase, CHLORIDE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D., Abendroth, J.
Deposit date:2016-11-30
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Brucella canis Acyl-CoA Synthetase
To Be Published
5VPV
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CRYSTAL STRUCTURE OF APO CRYPTOCOCCUS NEOFORMANS H99 ACETYL-COA SYNTHETASE WITH AN ACETYLATED ACTIVE SITE LYSINE
Descriptor:Acetyl-coenzyme A synthetase, GLYCEROL, PHOSPHATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D., Davies, D.R., Calhoun, B.
Deposit date:2017-05-05
Release date:2017-05-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of Apo Cryptococcus neoformans H99 Acetyl-CoA Synthetase with an Acetylated Active Site Lysine
to be published
6C97
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CRYSTAL STRUCTURE OF FCRN AT PH3
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, GLYCEROL
Authors:Fox III, D., Fairman, J.W.
Deposit date:2018-01-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
PLoS Biol., 16, 2018
6C98
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CRYSTAL STRUCTURE OF FCRN BOUND TO UCB-84
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, CYSTEINE, ...
Authors:Fox III, D., Lukacs, C.M.
Deposit date:2018-01-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
PLoS Biol., 16, 2018
6C99
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CRYSTAL STRUCTURE OF FCRN BOUND TO UCB-303
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, methyl 7-(3,5-difluorophenyl)-5-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate, ...
Authors:Fox III, D., Abendroth, J., Porter, J., Deboves, H.
Deposit date:2018-01-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
PLoS Biol., 16, 2018
3C5R
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CRYSTAL STRUCTURE OF THE BARD1 ANKYRIN REPEAT DOMAIN AND ITS FUNCTIONAL CONSEQUENCES
Descriptor:BRCA1-associated RING domain protein 1
Authors:Fox III, D., Le Trong, I., Stenkamp, R.E., Klevit, R.E.
Deposit date:2008-02-01
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences.
J.Biol.Chem., 283, 2008
4MYQ
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SELECTIVE INHIBITION OF THE CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B WITH A-33
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, (4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid, MAGNESIUM ION, ...
Authors:Fox III, D., Edwards, T.E.
Deposit date:2013-09-27
Release date:2014-01-01
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the design of selective phosphodiesterase 4B inhibitors.
Cell Signal, 26, 2014
4NW7
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PDE4 CATALYTIC DOMAIN
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Fox III, D., Edwards, T.E.
Deposit date:2013-12-05
Release date:2014-10-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of triazines as selective PDE4B versus PDE4D inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
6BOJ
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN AND UCR2 REGULATORY HELIX WITH BPN5004
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Fox III, D., Fairman, J.W., Gurney, M.E.
Deposit date:2017-11-20
Release date:2018-08-22
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice.
Neuropsychopharmacology, 43, 2018
6NJJ
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN AND UCR2 REGULATORY HELIX WITH BPN14770
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Fox III, D., Fairman, J.W., Gurney, M.E.
Deposit date:2019-01-03
Release date:2019-05-08
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
J.Med.Chem., 62, 2019
4U83
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STRUCTURE OF BRUCELLA ABORTUS BUTYRYL-COA DEHYDROGENASE
Descriptor:Acyl-CoA dehydrogenase, 1,2-ETHANEDIOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2014-07-31
Release date:2014-12-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Butyryl-CoA dehydrogenase from Brucella Abortus.
To Be Published
4WTD
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
Descriptor:RNA PRIMER TEMPLATE AUAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Fox III, D., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTM
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP
Descriptor:RNA TEMPLATE UAGG, RNA PRIMER CC, RNA-directed RNA polymerase, ...
Authors:Edwards, T.E., Appleby, T.C., Fox III, D.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
5UJ2
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 NETA HAIRPOIN LOOP DELETION IN COMPLEX WITH GS-639476 (DIPHSOHATE VERSION OF GS-9813), MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
Descriptor:RNA (5'-R(*AP*UP*AP*AP*AP*UP*UP*U)-3'), Genome polyprotein, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Fox III, D., Appleby, T.C., Murakami, E., Rey, A., McGrath, M.E.
Deposit date:2017-01-16
Release date:2017-03-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg. Med. Chem. Lett., 27, 2017
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