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4QH4
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BU of 4qh4 by Molmil
The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in acetate buffer at pH3
Descriptor: ACETATE ION, DODECYL-BETA-D-MALTOSIDE, Proton-gated ion channel, ...
Authors:Fourati, Z, Delarue, M, Sauguet, L.
Deposit date:2014-05-26
Release date:2015-07-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural characterization of potential modulation sites in the extracellular domain of the prokaryotic pentameric proton-gated ion channel GLIC
To be Published
4QH1
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BU of 4qh1 by Molmil
The GLIC pentameric Ligand-Gated Ion Channel (wild-type) in complex with bromoacetate
Descriptor: BROMIDE ION, Proton-gated ion channel, SODIUM ION, ...
Authors:Fourati, Z, Delarue, M, Sauguet, L.
Deposit date:2014-05-26
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural characterization of potential modulation sites in the extracellular domain of the prokaryotic pentameric proton-gated ion channel GLIC
Acta Crystallogr.,Sect.D, 2015
4QH5
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BU of 4qh5 by Molmil
The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in phosphate buffer
Descriptor: CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Fourati, Z, Delarue, M, Sauguet, L.
Deposit date:2014-05-26
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural characterization of potential modulation sites in the extracellular domain of the prokaryotic pentameric proton-gated ion channel GLIC
Acta Crystallogr.,Sect.D, 2015
4LUN
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BU of 4lun by Molmil
Structure of the N-terminal mIF4G domain from S. cerevisiae Upf2, a protein involved in the degradation of mRNAs containing premature stop codons
Descriptor: CHLORIDE ION, Nonsense-mediated mRNA decay protein 2
Authors:Fourati, Z, Roy, B, Millan, C, Courreux, P.D, Kervestin, S, van Tilbeurgh, H, He, F, Uson, I, Jacobson, A, Graille, M.
Deposit date:2013-07-25
Release date:2014-07-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.641 Å)
Cite:A highly conserved region essential for NMD in the Upf2 N-terminal domain.
J.Mol.Biol., 426, 2014
5L4H
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BU of 5l4h by Molmil
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)
Descriptor: 5-(2-bromoethyl)-5-ethyl-1,3-diazinane-2,4,6-trione, CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Fourati, Z, Ruza, R.R, Delarue, M.
Deposit date:2016-05-25
Release date:2016-12-21
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
J. Biol. Chem., 292, 2017
5L4E
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BU of 5l4e by Molmil
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental
Descriptor: 5-ethyl-5-[(2R)-pentan-2-yl]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione, CHLORIDE ION, DODECANE, ...
Authors:Fourati, Z, Ruza, R.R, Delarue, M.
Deposit date:2016-05-25
Release date:2016-12-21
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
J. Biol. Chem., 292, 2017
5MVM
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BU of 5mvm by Molmil
X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol
Descriptor: 2,6-BIS(1-METHYLETHYL)PHENOL, ACETATE ION, CHLORIDE ION, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2017-01-16
Release date:2018-03-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol
To Be Published
5MVN
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BU of 5mvn by Molmil
X-ray structure of the M205W mutant of GLIC in complex with propofol
Descriptor: 2,6-BIS(1-METHYLETHYL)PHENOL, ACETATE ION, CHLORIDE ION, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2017-01-16
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Cell Rep, 23, 2018
5MUO
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BU of 5muo by Molmil
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with propofol
Descriptor: 2,6-BIS(1-METHYLETHYL)PHENOL, ACETATE ION, CHLORIDE ION, ...
Authors:Fourati, Z, Ruza, R.R, Delarue, M.
Deposit date:2017-01-13
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Cell Rep, 23, 2018
5MZQ
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BU of 5mzq by Molmil
X-ray structure of the M205W mutant of GLIC in complex with bromoform
Descriptor: (3R)-3-(dodecanoyloxy)tetradecanoic acid, 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ACETATE ION, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2017-02-01
Release date:2018-02-28
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Cell Rep, 23, 2018
5MZR
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BU of 5mzr by Molmil
X-ray structure of the H235Q mutant of GLIC in complex with propofol
Descriptor: 2,6-BIS(1-METHYLETHYL)PHENOL, ACETATE ION, CHLORIDE ION, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2017-02-01
Release date:2018-02-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray structure of the H235Q mutant of GLIC in complex with propofol
To Be Published
5MZT
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BU of 5mzt by Molmil
X-ray structure of the H235Q mutant of GLIC in complex with bromoform
Descriptor: ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2017-02-01
Release date:2018-02-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray structure of the H235Q mutant of GLIC in complex with bromoform
To Be Published
6EMX
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BU of 6emx by Molmil
X-ray structure of the N15'C mutant of GLIC in complex with bromoform
Descriptor: CHLORIDE ION, Proton-gated ion channel, SODIUM ION, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2017-10-03
Release date:2018-06-20
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Cell Rep, 23, 2018
6HJA
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BU of 6hja by Molmil
Xray structure of GLIC in complex with glutarate
Descriptor: CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECANE, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2018-09-03
Release date:2019-09-18
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel.
Acta Crystallogr D Struct Biol, 76, 2020
6HJ3
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BU of 6hj3 by Molmil
Xray structure of GLIC in complex with fumarate
Descriptor: CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2018-08-31
Release date:2019-09-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel.
Acta Crystallogr D Struct Biol, 76, 2020
6HJI
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BU of 6hji by Molmil
Xray structure of GLIC in complex with crotonate
Descriptor: BUTENOIC ACID, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2018-09-03
Release date:2019-09-18
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel.
Acta Crystallogr D Struct Biol, 76, 2020
6HPP
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BU of 6hpp by Molmil
X-ray structure of GLIC in complex with propionate
Descriptor: CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, PROPANOIC ACID, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2018-09-21
Release date:2019-10-09
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel.
Acta Crystallogr D Struct Biol, 76, 2020
6HJB
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BU of 6hjb by Molmil
Xray structure of GLIC in complex with malonate
Descriptor: CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2018-09-03
Release date:2019-09-18
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel.
Acta Crystallogr D Struct Biol, 76, 2020
6HJZ
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BU of 6hjz by Molmil
Xray structure of GLIC in complex with succinate
Descriptor: CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Fourati, Z, Delarue, M.
Deposit date:2018-09-04
Release date:2019-09-18
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel.
Acta Crystallogr D Struct Biol, 76, 2020
5IUX
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BU of 5iux by Molmil
GLIC-V135C bimane labelled X-ray structure
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione, ACETATE ION, ...
Authors:Fourati, Z, Menny, A, Delarue, M.
Deposit date:2016-03-18
Release date:2017-03-29
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of a pre-active conformation of a pentameric channel receptor.
Elife, 6, 2017
5L47
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BU of 5l47 by Molmil
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with cyanoselenobarbital (seleniated barbiturate)
Descriptor: 2-[5-ethyl-2,4,6-tris(oxidanylidene)-1,3-diazinan-5-yl]ethyl selenocyanate, ACETATE ION, CHLORIDE ION, ...
Authors:Reinholds Ruza, R, Fourati, Z, Delarue, M.
Deposit date:2016-05-25
Release date:2016-12-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
J. Biol. Chem., 292, 2017
5MUR
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BU of 5mur by Molmil
X-ray structure of the F14'A mutant of GLIC in complex with propofol
Descriptor: 2,6-BIS(1-METHYLETHYL)PHENOL, ACETATE ION, CHLORIDE ION, ...
Authors:Sauguet, L, Fourati, Z, Delarue, M.
Deposit date:2017-01-13
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Cell Rep, 23, 2018
5NJY
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BU of 5njy by Molmil
X-ray structure of the H235Q mutant of GLIC
Descriptor: Proton-gated ion channel
Authors:Hu, H, Fourati, Z, Delarue, M.
Deposit date:2017-03-30
Release date:2018-05-16
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:X-ray structure of the H235Q mutant of GLIC
To Be Published
5NKJ
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BU of 5nkj by Molmil
X-ray structure of the N239C mutant of GLIC
Descriptor: Proton-gated ion channel
Authors:Hu, H, Fourati, Z, Delarue, M.
Deposit date:2017-03-31
Release date:2018-06-20
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.74 Å)
Cite:Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Cell Rep, 23, 2018
4ZZC
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BU of 4zzc by Molmil
The GLIC pentameric Ligand-Gated Ion Channel open form complexed to xenon
Descriptor: ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
Authors:Sauguet, L, Fourati, Z, Prange, T, Delarue, M, Colloc'h, N.
Deposit date:2015-05-22
Release date:2016-03-02
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel.
Plos One, 11, 2016

 

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