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1DJ0
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THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION
Descriptor:PSEUDOURIDINE SYNTHASE I, CHLORIDE ION
Authors:Foster, P.G., Huang, L., Santi, D.V., Stroud, R.M.
Deposit date:1999-11-30
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I.
Nat.Struct.Biol., 7, 2000
1SQF
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THE CRYSTAL STRUCTURE OF E. COLI FMU BINARY COMPLEX WITH S-ADENOSYLMETHIONINE AT 2.1 A RESOLUTION
Descriptor:SUN protein, S-ADENOSYLMETHIONINE
Authors:Foster, P.G., Nunes, C.R., Greene, P., Moustakas, D., Stroud, R.M.
Deposit date:2004-03-18
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The First Structure of an RNA m5C Methyltransferase, Fmu, Provides Insight into Catalytic Mechanism and Specific Binding of RNA Substrate
Structure, 11, 2003
1SQG
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THE CRYSTAL STRUCTURE OF THE E. COLI FMU APOENZYME AT 1.65 A RESOLUTION
Descriptor:SUN protein
Authors:Foster, P.G., Nunes, C.R., Greene, P., Moustakas, D., Stroud, R.M.
Deposit date:2004-03-18
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The First Structure of an RNA m5C Methyltransferase, Fmu, Provides Insight into Catalytic Mechanism and Specific Binding of RNA Substrate
Structure, 11, 2003
2IST
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CRYSTAL STRUCTURE OF RLUD FROM E. COLI
Descriptor:Ribosomal large subunit pseudouridine synthase D, CHLORIDE ION, BICARBONATE ION
Authors:Foster, P.G., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2006-10-18
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of RluD from E. coli
TO BE PUBLISHED
4ANU
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COMPLEXES OF PI3KGAMMA WITH ISOFORM SELECTIVE INHIBITORS.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION, 3-AMINO-N-METHYL-6-[3-(1H-TETRAZOL-5-YL)PHENYL]PYRAZINE-2-CARBOXAMIDE
Authors:Foster, P.G., Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
4ANV
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COMPLEXES OF PI3KGAMMA WITH ISOFORM SELECTIVE INHIBITORS.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION, 2-{4-[(4'-METHOXYBIPHENYL-3-YL)SULFONYL]PIPERAZIN-1-YL}-3-(4-METHOXYPHENYL)PYRAZINE
Authors:Foster, P.G., Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
4ANW
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COMPLEXES OF PI3KGAMMA WITH ISOFORM SELECTIVE INHIBITORS.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION, 3-AMINO-6-{4-CHLORO-3-[(2,3-DIFLUOROPHENYL)SULFAMOYL]PHENYL}-N-METHYLPYRAZINE-2-CARBOXAMIDE
Authors:Foster, P.G., Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
4ANX
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COMPLEXES OF PI3KGAMMA WITH ISOFORM SELECTIVE INHIBITORS.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 5-{3-[(4-{3-[4-(1-methylethyl)phenyl]pyrazin-2-yl}piperazin-1-yl)sulfonyl]phenyl}pyrimidin-2-amine
Authors:Foster, P.G., Lougheed, J.C.
Deposit date:2012-03-22
Release date:2012-05-09
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors
J.Med.Chem., 55, 2012
1KEZ
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CRYSTAL STRUCTURE OF THE MACROCYCLE-FORMING THIOESTERASE DOMAIN OF ERYTHROMYCIN POLYKETIDE SYNTHASE (DEBS TE)
Descriptor:ERYTHRONOLIDE SYNTHASE
Authors:Tsai, S.-C., Miercke, L.J.W., Krucinski, J., Gokhale, R., Chen, J.C.-H., Foster, P.G., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2001-11-19
Release date:2002-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proc.Natl.Acad.Sci.USA, 98, 2001
3FLI
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DISCOVERY OF XL335, A HIGHLY POTENT, SELECTIVE AND ORALLY-ACTIVE AGONIST OF THE FARNESOID X RECEPTOR (FXR)
Descriptor:Bile acid receptor, 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
Authors:Foster, P.G., Stout, T.J.
Deposit date:2008-12-18
Release date:2009-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).
J.Med.Chem., 52, 2009
1LCA
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LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
Authors:Birdsall, D.L., Finer-Moore, J., Stroud, R.M.
Deposit date:1995-06-22
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1LCB
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LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DTMP AND H2FOLATE
Descriptor:THYMIDYLATE SYNTHASE, THYMIDINE-5'-PHOSPHATE, DIHYDROFOLIC ACID
Authors:Birdsall, D.L., Finer-Moore, J., Stroud, R.M.
Deposit date:1995-06-22
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1LCE
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LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID
Authors:Birdsall, D.L., Finer-Moore, J., Stroud, R.M.
Deposit date:1995-06-22
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1THY
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REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.
Deposit date:1993-04-02
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
2TDM
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STRUCTURE OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-03-28
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1BO7
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THYMIDYLATE SYNTHASE R179T MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BO8
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THYMIDYLATE SYNTHASE R178T MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP0
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THYMIDYLATE SYNTHASE R23I MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-11
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP6
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THYMIDYLATE SYNTHASE R23I, R179T DOUBLE MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R.J., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-13
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BPJ
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THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R.J., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-11
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1JMF
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1JMG
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1JMH
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1JMI
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1NJA
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THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1996-01-23
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry, 35, 1996
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