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1M61
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CRYSTAL STRUCTURE OF THE APO SH2 DOMAINS OF ZAP-70
Descriptor:TYROSINE-PROTEIN KINASE ZAP-70, PHOSPHATE ION
Authors:Folmer, R.H.A., Geschwindner, S., Xue, Y.
Deposit date:2002-07-11
Release date:2003-07-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem
Biochemistry, 41, 2002
2V00
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X-RAY CRYSTAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH COMPOUND 1
Descriptor:ENDOTHIAPEPSIN, GLYCEROL, ACETATE ION, ...
Authors:Geschwindner, S., Olsson, L.L., Deinum, J., Albert, J.S., Edwards, P.D., De Beer, T., Folmer, R.H.A.
Deposit date:2007-05-03
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of a Novel Warhead Against Beta-Secretase Through Fragment-Based Lead Generation.
J.Med.Chem., 50, 2007
2VA6
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X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 24
Descriptor:BETA SECRETASE 1, IODIDE ION, (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
Authors:Edwards, P.D., Albert, J.S., Sylvester, M., Aharony, D., Andisik, D., Callaghan, O., Campbell, J.B., Carr, R.A., Chessari, G., Congreve, M., Frederickson, M., Folmer, R.H.A., Geschwindner, S., Koether, G., Kolmodin, K., Krumrine, J., Mauger, R.C., Murray, C.W., Olsson, L.L., Patel, S., Spear, N., Tian, G.
Deposit date:2007-08-30
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine Beta-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency.
J.Med.Chem., 50, 2007
2VA7
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X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 27
Descriptor:BETA-SECRETASE 1 ., IODIDE ION, (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
Authors:Edwards, P.D., Albert, J.S., Sylvester, M., Aharony, D., Andisik, D., Callaghan, O., Campbell, J.B., Carr, R.A., Chessari, G., Congreve, M., Frederickson, M., Folmer, R.H.A., Geschwindner, S., Koether, G., Kolmodin, K., Krumrine, J., Mauger, R.C., Murray, C.W., Olsson, L.L., Patel, S., Spear, N., Tian, G.
Deposit date:2007-08-30
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine Beta-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency.
J.Med.Chem., 50, 2007
2VCQ
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-26
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VCW
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-27
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VCX
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.1A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, MAGNESIUM ION, GLUTATHIONE, ...
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-27
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VCZ
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 3-(4-nitrophenyl)-1H-pyrazole
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-28
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VD0
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.2A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid, ...
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-28
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2VD1
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COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.25A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid, ...
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-28
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
2GVA
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REFINED SOLUTION STRUCTURE OF THE TYR 41--> HIS MUTANT OF THE M13 GENE V PROTEIN. A COMPARISON WITH THE CRYSTAL STRUCTURE
Descriptor:GENE V PROTEIN
Authors:Folkers, P.J.M., Nilges, M., Folmer, R.H.A., Prompers, J.J., Konings, R.N.H., Hilbers, C.W.
Deposit date:1995-07-27
Release date:1995-10-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Refined solution structure of the Tyr41-->His mutant of the M13 gene V protein. A comparison with the crystal structure.
Eur.J.Biochem., 232, 1995
2GVB
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REFINED SOLUTION STRUCTURE OF THE TYR 41--> HIS MUTANT OF THE M13 GENE V PROTEIN. A COMPARISON WITH THE CRYSTAL STRUCTURE
Descriptor:GENE V PROTEIN
Authors:Folkers, P.J.M., Nilges, M., Folmer, R.H.A., Prompers, J.J., Konings, R.N.H., Hilbers, C.W.
Deposit date:1995-07-27
Release date:1995-10-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Refined solution structure of the Tyr41-->His mutant of the M13 gene V protein. A comparison with the crystal structure.
Eur.J.Biochem., 232, 1995
1PFS
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SOLUTION NMR STRUCTURE OF THE SINGLE-STRANDED DNA BINDING PROTEIN OF THE FILAMENTOUS PSEUDOMONAS PHAGE PF3, MINIMIZED AVERAGE STRUCTURE
Descriptor:PF3 SINGLE-STRANDED DNA BINDING PROTEIN
Authors:Folmer, R.H.A., Nilges, M., Konings, R.N.H., Hilbers, C.W.
Deposit date:1996-08-03
Release date:1997-02-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the single-stranded DNA binding protein of the filamentous Pseudomonas phage Pf3: similarity to other proteins binding to single-stranded nucleic acids.
EMBO J., 14, 1995
1F4K
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CRYSTAL STRUCTURE OF THE REPLICATION TERMINATOR PROTEIN/B-SITE DNA COMPLEX
Descriptor:5'-D(*CP*TP*AP*TP*GP*AP*AP*CP*AP*TP*AP*AP*TP*GP*TP*TP*CP*AP*TP*AP*G)-3', 5'-D(*CP*TP*AP*TP*GP*AP*AP*CP*AP*TP*TP*AP*TP*GP*TP*TP*CP*AP*TP*AP*G)-3', REPLICATION TERMINATION PROTEIN
Authors:Wilce, J.A., Vivian, J.P., Hastings, A.F., Otting, G., Folmer, R.H.A., Duggin, I.G., Wake, R.G., Wilce, M.C.J.
Deposit date:2000-06-08
Release date:2001-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest
Nat.Struct.Biol., 8, 2001
2CPB
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SOLUTION NMR STRUCTURES OF THE MAJOR COAT PROTEIN OF FILAMENTOUS BACTERIOPHAGE M13 SOLUBILIZED IN DODECYLPHOSPHOCHOLINE MICELLES, 25 LOWEST ENERGY STRUCTURES
Descriptor:M13 MAJOR COAT PROTEIN
Authors:Papavoine, C.H.M., Christiaans, B.E.C., Folmer, R.H.A., Konings, R.N.H., Hilbers, C.W.
Deposit date:1998-04-16
Release date:1998-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the M13 major coat protein in detergent micelles: a basis for a model of phage assembly involving specific residues.
J.Mol.Biol., 282, 1998
2CPS
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SOLUTION NMR STRUCTURES OF THE MAJOR COAT PROTEIN OF FILAMENTOUS BACTERIOPHAGE M13 SOLUBILIZED IN SODIUM DODECYL SULPHATE MICELLES, 25 LOWEST ENERGY STRUCTURES
Descriptor:M13 MAJOR COAT PROTEIN
Authors:Papavoine, C.H.M., Christiaans, B.E.C., Folmer, R.H.A., Konings, R.N.H., Hilbers, C.W.
Deposit date:1998-04-16
Release date:1998-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the M13 major coat protein in detergent micelles: a basis for a model of phage assembly involving specific residues.
J.Mol.Biol., 282, 1998
2VA5
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X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 8C
Descriptor:BETA-SECRETASE 1 ., IODIDE ION, 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
Authors:Edwards, P.D., Albert, J.S., Sylvester, M., Aharony, D., Andisik, D., Callaghan, O., Campbell, J.B., Carr, R.A., Chessari, G., Congreve, M., Frederickson, M., Folmer, R.H.A., Geschwindner, S., Koether, G., Kolmodin, K., Krumrine, J., Mauger, R.C., Murray, C.W., Olsson, L., Patel, S., Spear, N., Tian, G.
Deposit date:2007-08-30
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine Beta-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency.
J.Med.Chem., 50, 2007
2JFN
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI GLUTAMATE RACEMASE IN COMPLEX WITH L- GLUTAMATE AND ACTIVATOR UDP-MURNAC-ALA
Descriptor:GLUTAMATE RACEMASE, GLUTAMIC ACID, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE
Authors:Lundqvist, T.
Deposit date:2007-02-03
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
2JFO
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CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECALIS GLUTAMATE RACEMASE IN COMPLEX WITH D- AND L-GLUTAMATE
Descriptor:GLUTAMATE RACEMASE, GLUTAMIC ACID, D-GLUTAMIC ACID
Authors:Lundqvist, T.
Deposit date:2007-02-03
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
2JFP
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CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECALIS GLUTAMATE RACEMASE IN COMPLEX WITH D- GLUTAMATE
Descriptor:GLUTAMATE RACEMASE, D-GLUTAMIC ACID, CALCIUM ION
Authors:Lundqvist, T.
Deposit date:2007-02-03
Release date:2007-07-03
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
2JFQ
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS GLUTAMATE RACEMASE IN COMPLEX WITH D- GLUTAMATE
Descriptor:GLUTAMATE RACEMASE, D-GLUTAMIC ACID
Authors:Lundqvist, T.
Deposit date:2007-02-04
Release date:2007-07-03
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
2JFU
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CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECIUM GLUTAMATE RACEMASE IN COMPLEX WITH PHOSPHATE
Descriptor:GLUTAMATE RACEMASE, PHOSPHATE ION
Authors:Lundqvist, T.
Deposit date:2007-02-04
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
2JFV
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CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECIUM GLUTAMATE RACEMASE IN COMPLEX WITH CITRATE
Descriptor:GLUTAMATE RACEMASE, CITRATE ANION
Authors:Lundqvist, T.
Deposit date:2007-02-06
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
2JFW
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CRYSTAL STRUCTURE OF ENTEROCOCCUS FAECIUM GLUTAMATE RACEMASE IN COMPLEX WITH TARTRATE
Descriptor:GLUTAMATE RACEMASE, L(+)-TARTARIC ACID
Authors:Lundqvist, T.
Deposit date:2007-02-06
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
2JFX
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI GLUTAMATE RACEMASE IN COMPLEX WITH D-GLUTAMATE
Descriptor:GLUTAMATE RACEMASE, D-GLUTAMIC ACID
Authors:Xue, Y., Lundqvist, T.
Deposit date:2007-02-06
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Exploitation of Structural and Regulatory Diversity in Glutamate Racemases
Nature, 447, 2007
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