Author results

1OKK
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HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES
Descriptor:SIGNAL RECOGNITION PARTICLE PROTEIN, CELL DIVISION PROTEIN FTSY, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Focia, P.J., Freymann, D.M.
Deposit date:2003-07-26
Release date:2004-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Heterodimeric Gtpase Core of the Srp Targeting Complex
Science, 303, 2004
1TC1
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A 1.4 ANGSTROM CRYSTAL STRUCTURE FOR THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE OF TRYPANOSOMA CRUZI
Descriptor:PROTEIN (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE), FORMYCIN B, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Focia, P.J., Craig III, S.P., Nieves-Alicea, R., Fletterick, R.J., Eakin, A.E.
Deposit date:1998-09-30
Release date:1999-10-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
Biochemistry, 37, 1998
1TC2
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TERNARY SUBSTRATE COMPLEX OF THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE FROM TRYPANOSOMA CRUZI
Descriptor:PROTEIN (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ...
Authors:Focia, P.J., Craig III, S.P., Eakin, A.E.
Deposit date:1998-11-04
Release date:2000-03-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Approaching the transition state in the crystal structure of a phosphoribosyltransferase.
Biochemistry, 37, 1998
2CNW
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GDPALF4 COMPLEX OF THE SRP GTPASES FFH AND FTSY
Descriptor:SIGNAL RECOGNITION PARTICLE PROTEIN, CELL DIVISION PROTEIN FTSY, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Focia, P.J., Gawronski-Salerno, J., Coon V, J.S., Freymann, D.M.
Deposit date:2006-05-24
Release date:2006-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of a Gdp:Alf(4) Complex of the Srp Gtpases Ffh and Ftsy, and Identification of a Peripheral Nucleotide Interaction Site.
J.Mol.Biol., 360, 2006
2IYL
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STRUCTURE OF AN FTSY:GDP COMPLEX
Descriptor:CELL DIVISION PROTEIN FTSY, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Focia, P.J., Freymann, D.M.
Deposit date:2006-07-18
Release date:2007-01-02
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases.
Proteins, 66, 2007
1I0I
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ANALYSIS OF AN INVARIANT ASPARTIC ACID IN HPRTS-GLUTAMINE MUTANT
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ...
Authors:Canyuk, B., Focia, P.J., Eakin, A.E.
Deposit date:2001-01-29
Release date:2002-05-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Biochemistry, 40, 2001
1I0L
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ANALYSIS OF AN INVARIANT ASPARTIC ACID IN HPRTS-ASPARAGINE MUTANT
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ...
Authors:Canyuk, B., Focia, P.J., Eakin, A.E.
Deposit date:2001-01-29
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Biochemistry, 40, 2001
1I13
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ANALYSIS OF AN INVARIANT ASPARTIC ACID IN HPRTS-ALANINE MUTANT
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ...
Authors:Canyuk, B., Focia, P.J., Eakin, A.E.
Deposit date:2001-01-30
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Biochemistry, 40, 2001
1I14
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ANALYSIS OF AN INVARIANT ASPARTIC ACID IN HPRTS-GLUTAMIC ACID MUTANT
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ...
Authors:Canyuk, B., Focia, P.J., Eakin, A.E.
Deposit date:2001-01-30
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Biochemistry, 40, 2001
1IEL
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CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH CEFTAZIDIME
Descriptor:beta-lactamase, PHOSPHATE ION, ACYLATED CEFTAZIDIME
Authors:Powers, R.A., Caselli, E., Focia, P.J., Prati, F., Shoichet, B.K.
Deposit date:2001-04-10
Release date:2001-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.
Biochemistry, 40, 2001
1IEM
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CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI IN COMPLEX WITH A BORONIC ACID INHIBITOR (1, CEFB4)
Descriptor:beta-lactamase, PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE
Authors:Powers, R.A., Caselli, E., Focia, P.J., Prati, F., Shoichet, B.K.
Deposit date:2001-04-10
Release date:2001-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.
Biochemistry, 40, 2001
1J7J
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CRYSTAL STRUCTURE OF THE HPRT FROM SALMONELLA TYPHIMURIUM
Descriptor:hypoxanthine phosphoribosyltransferase, MAGNESIUM ION
Authors:Lee, C.C., Focia, P.J., Spraggon, G., Eakin, A.E.
Deposit date:2001-05-16
Release date:2003-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the HPRT from Salmonella Typhimurium at 2.3 A Resolution
To be Published
1KVL
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X-RAY CRYSTAL STRUCTURE OF AMPC S64G MUTANT BETA-LACTAMASE IN COMPLEX WITH SUBSTRATE AND PRODUCT FORMS OF CEPHALOTHIN
Descriptor:Beta-lactamase, PHOSPHATE ION, 2-[CARBOXY-(2-THIOPHEN-2-YL-ACETYLAMINO)-METHYL]-5-METHYL-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, ...
Authors:Beadle, B.M., Trehan, I., Focia, P.J., Shoichet, B.K.
Deposit date:2002-01-27
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase.
Structure, 10, 2002
1KVM
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X-RAY CRYSTAL STRUCTURE OF AMPC WT BETA-LACTAMASE IN COMPLEX WITH COVALENTLY BOUND CEPHALOTHIN
Descriptor:beta-lactamase, PHOSPHATE ION, 5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID
Authors:Beadle, B.M., Trehan, I., Focia, P.J., Shoichet, B.K.
Deposit date:2002-01-27
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase.
Structure, 10, 2002
1MXO
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AMPC BETA-LACTAMASE IN COMPLEX WITH AN M.CARBOXYPHENYLGLYCYLBORONIC ACID BEARING THE CEPHALOTHIN R1 SIDE CHAIN
Descriptor:Beta-lactamase, PHOSPHATE ION, (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID
Authors:Morandi, F., Caselli, E., Morandi, S., Focia, P.J., Blazquez, J., Shoichet, B.K., Prati, F.
Deposit date:2002-10-02
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Nanomolar inhibitors of AmpC beta-lactamase.
J.Am.Chem.Soc., 125, 2003
1MY8
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AMPC BETA-LACTAMASE IN COMPLEX WITH AN M.CARBOXYPHENYLGLYCYLBORONIC ACID BEARING THE CEPHALOTHIN R1 SIDE CHAIN
Descriptor:beta-lactamase, PHOSPHATE ION, (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID
Authors:Morandi, F., Caselli, E., Morandi, S., Focia, P.J., Blazquez, J., Shoichet, B.K., Prati, F.
Deposit date:2002-10-03
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Nanomolar inhibitors of AmpC beta-lactamase.
J.Am.Chem.Soc., 125, 2003
1P4F
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DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
Descriptor:Death-associated protein kinase 1, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE
Authors:Velentza, A.V., Wainwright, M.S., Zasadzki, M., Mirzoeva, S., Haiech, J., Focia, P.J., Egli, M., Watterson, D.M.
Deposit date:2003-04-23
Release date:2004-09-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Bioorg.Med.Chem.Lett., 13, 2003
2BOB
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POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA)
Descriptor:ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, POTASSIUM CHANNEL KCSA, ...
Authors:Lenaeus, M.J., Vamvouka, M., Focia, P.J., Gross, A.
Deposit date:2005-04-09
Release date:2005-04-27
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural Basis of Tea Blockade in a Model Potassium Channel
Nat.Struct.Mol.Biol., 12, 2005
2BOC
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POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)
Descriptor:ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, POTASSIUM CHANNEL KCSA, ...
Authors:Lenaeus, M.J., Vamvouka, M., Focia, P.J., Gross, A.
Deposit date:2005-04-09
Release date:2005-04-27
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Basis of Tea Blockade in a Model Potassium Channel
Nat.Struct.Mol.Biol., 12, 2005
2JK5
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POTASSIUM CHANNEL KCSA IN COMPLEX WITH TETRABUTYLAMMONIUM IN HIGH K
Descriptor:ANTIBODY FAB FRAGMENT LIGHT CHAIN, ANTIBODY FAB FRAGMENT HEAVY CHAIN, VOLTAGE-GATED POTASSIUM CHANNEL, ...
Authors:Lenaeus, M.J., Focia, P.J., Wagner, T., Gross, A.
Deposit date:2008-08-15
Release date:2009-11-17
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site.
Biochemistry, 53, 2014
2O26
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STRUCTURE OF A CLASS III RTK SIGNALING ASSEMBLY
Descriptor:Kit ligand, Mast/stem cell growth factor receptor, BETA-L-FUCOSE, ...
Authors:Liu, H., Chen, X., Focia, P.J., He, X.
Deposit date:2006-11-29
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases.
Embo J., 26, 2007
2W0F
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POTASSIUM CHANNEL KCSA-FAB COMPLEX WITH TETRAOCTYLAMMONIUM
Descriptor:ANTIBODY FAB FRAGMENT LIGHT CHAIN, ANTIBODY FAB FRAGMENT HEAVY CHAIN, VOLTAGE-GATED POTASSIUM CHANNEL, ...
Authors:Lenaeus, M.J., Focia, P.J., Wagner, T., Gross, A.
Deposit date:2008-08-14
Release date:2009-11-17
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site.
Biochemistry, 53, 2014
3EJJ
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STRUCTURE OF M-CSF BOUND TO THE FIRST THREE DOMAINS OF FMS
Descriptor:Colony stimulating factor-1, Macrophage colony-stimulating factor 1 receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Chen, X., Liu, H., Focia, P.J., Shim, A., He, X.
Deposit date:2008-09-18
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.
Proc.Natl.Acad.Sci.USA, 105, 2008
3IFX
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CRYSTAL STRUCTURE OF THE SPIN-LABELED KCSA MUTANT V48R1
Descriptor:Voltage-gated potassium channel, POTASSIUM ION, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ...
Authors:Cieslak, J.A., Focia, P.J., Gross, A.
Deposit date:2009-07-26
Release date:2010-02-09
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (3.56 Å), EPR
Cite:Electron Spin-Echo Envelope Modulation (ESEEM) Reveals Water and Phosphate Interactions with the KcsA Potassium Channel
Biochemistry, 49, 2010
4AGG
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STRUCTURE OF A TETRAMERIC GALECTIN FROM CINACHYRELLA SP. (BALL SPONGE)
Descriptor:GALECTIN, CHLORIDE ION
Authors:Freymann, D.M., Focia, P.J., Sakai, R., Swanson, G.T.
Deposit date:2012-01-27
Release date:2012-08-29
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structure of a Tetrameric Galectin from Cinachyrella Sp. (Ball Sponge).
Acta Crystallogr.,Sect.D, 68, 2012
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