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6MED
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:antibody HEPC3 Heavy Chain, antibody HEPC3 Light Chain, SULFATE ION
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
6MEE
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:antibody HEPC74 Heavy Chain, antibody HEPC74 Light Chain
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
6MEF
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:antibody AR3C Heavy Chain, antibody AR3C Light Chain
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
6MEG
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:antibody HEPC46 Heavy Chain, antibody HEPC46 Light Chain
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
6MEH
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:E2 glycoprotein, antibody HEPC74 Heavy Chain, antibody HEPC74 Light Chain, ...
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
6MEI
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:E2 glycoprotein, antibody HEPC3 Heavy Chain, antibody HEPC3 Light Chain, ...
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
6MEJ
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:antibody HEPC46 Heavy Chain, antibody HEPC46 Light Chain, E2 glycoprotein, ...
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
6MEK
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BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN
Descriptor:E2 GLYCOPROTEIN, HEPC3 Heavy Chain, HEPC3 Light Chain, ...
Authors:Flyak, A.I., Bjorkman, P.J.
Deposit date:2018-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Cell Host Microbe, 24, 2018
5KEL
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EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C2G4 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEM
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EBOV SGP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C13C6 AND BDBV91
Descriptor:BDBV91 variable Fab domain light chain, BDBV91 variable Fab domain heavy chain, c13C6 variable Fab domain heavy chain, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEN
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EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C4G7 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5UQY
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CRYSTAL STRUCTURE OF MARBURG VIRUS GP IN COMPLEX WITH THE HUMAN SURVIVOR ANTIBODY MR78
Descriptor:ENVELOPE GLYCOPROTEIN GP1, ENVELOPE GLYCOPROTEIN GP2, MR78 Fab light chain, ...
Authors:Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O.
Deposit date:2017-02-08
Release date:2017-03-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
6BP2
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THERAPEUTIC HUMAN MONOCLONAL ANTIBODY MR191 BOUND TO A MARBURGVIRUS GLYCOPROTEIN
Descriptor:Envelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ...
Authors:King, L.B., Fusco, M.L., Flyak, A.I., Ilinykh, P.A., Huang, K., Gunn, B., Kirchdoerfer, R.N., Hastie, K.M., Sangha, A.K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J.E.J., Saphire, E.O.
Deposit date:2017-11-21
Release date:2018-01-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (3.172 Å)
Cite:The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23, 2018
5HJ3
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CRYSTAL STRUCTURE OF HOST-PRIMED EBOLA VIRUS GP, GPCL.
Descriptor:Envelope glycoprotein, KZ52 Antibody Fragment, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bornholdt, Z.A., Fusco, M.L., Saphire, E.O.
Deposit date:2016-01-12
Release date:2016-03-09
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
Mbio, 7, 2016