7JTL
 
 | | Structure of SARS-CoV-2 ORF8 accessory protein | | Descriptor: | ORF8 protein, SODIUM ION | | Authors: | Flower, T.G, Buffalo, C.Z, Hooy, R.M, Allaire, M, Ren, X, Hurley, J.H. | | Deposit date: | 2020-08-18 | | Release date: | 2020-08-26 | | Last modified: | 2021-02-10 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6VME
 | | Human ESCRT-I heterotetramer headpiece | | Descriptor: | Multivesicular body subunit 12A, Tumor susceptibility gene 101 protein, Vacuolar protein sorting-associated protein 28 homolog, ... | | Authors: | Flower, T.G, Hurley, J.H, Tjahjono, N. | | Deposit date: | 2020-01-27 | | Release date: | 2020-05-20 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
Nat.Struct.Mol.Biol., 27, 2020
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7MU2
 | | Crystal Structure of WIPI2 in complex with W2IR of ATG16L1 | | Descriptor: | Autophagy-related protein 16-1, WD repeat domain phosphoinositide-interacting protein 2 | | Authors: | Strong, L.M, Flower, T.G, Buffalo, C.Z, Hurley, J.H. | | Deposit date: | 2021-05-14 | | Release date: | 2021-05-26 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.
Elife, 10, 2021
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4PSI
 | | PIH1D1/phospho-Tel2 complex | | Descriptor: | PIH1 domain-containing protein 1, Telomere length regulation protein TEL2 homolog | | Authors: | Smerdon, S.J, Boulton, S.J, Stach, L, Flower, T.G, Horejsi, Z. | | Deposit date: | 2014-03-07 | | Release date: | 2014-04-23 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex.
Cell Rep, 7, 2014
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4PSF
 | | PIH1D1 N-terminal domain | | Descriptor: | PIH1 domain-containing protein 1 | | Authors: | Smerdon, S.J, Boulton, S.J, Stach, L, Flower, T.G, Horejsi, Z. | | Deposit date: | 2014-03-07 | | Release date: | 2014-04-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.578 Å) | | Cite: | Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex.
Cell Rep, 7, 2014
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4JMR
 | | A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid | | Descriptor: | Env protein, Gag protein | | Authors: | Taylor, I.A, Goldstone, D.C, Flower, T.G, Ball, N.J. | | Deposit date: | 2013-03-14 | | Release date: | 2013-05-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A Unique Spumavirus Gag N-terminal Domain with Functional Properties of Orthoretroviral Matrix and Capsid.
Plos Pathog., 9, 2013
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4JNH
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8OKU
 | | Salt-Inducible Kinase 3 in complex with an inhibitor | | Descriptor: | Serine/threonine-protein kinase SIK3, ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide | | Authors: | Flower, T.G, Leonard, P.M, Lamers, M.B.A.C, Mollat, P. | | Deposit date: | 2023-03-29 | | Release date: | 2024-01-10 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
J.Med.Chem., 67, 2024
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