Author results

4UUU
  • Download 4uuu
  • View 4uuu
Molmil generated image of 4uuu
1.7 A RESOLUTION STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE REGULATORY DOMAIN (DEL 516-525) IN COMPLEX WITH SAM
Descriptor:CYSTATHIONINE BETA-SYNTHASE, S-ADENOSYLMETHIONINE, 1,2-ETHANEDIOL
Authors:Kopec, J., McCorvie, T.J., Fitzpatrick, F., Strain-Damerell, C., Froese, D.S., Tallant, C., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-07-31
Release date:2014-08-13
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
5IN3
  • Download 5in3
  • View 5in3
Molmil generated image of 5in3
CRYSTAL STRUCTURE OF GLUCOSE-1-PHOSPHATE BOUND NUCLEOTIDYLATED HUMAN GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
Descriptor:Galactose-1-phosphate uridylyltransferase, ZINC ION, 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, ...
Authors:Kopec, J., McCorvie, T., Tallant, C., Velupillai, S., Shrestha, L., Fitzpatrick, F., Patel, D., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2016-03-07
Release date:2016-03-30
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
Hum.Mol.Genet., 25, 2016
5FII
  • Download 5fii
  • View 5fii
Molmil generated image of 5fii
STRUCTURE OF A HUMAN ASPARTATE KINASE, CHORISMATE MUTASE AND TYRA DOMAIN.
Descriptor:PHENYLALANINE-4-HYDROXYLASE, PHENYLALANINE
Authors:Patel, D., Kopec, J., Shrestha, L., Fitzpatrick, F., Pinkas, D., Chaikuad, A., Dixon-Clarke, S., McCorvie, T.J., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2015-09-25
Release date:2016-03-30
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Ligand-Dependent Dimerization of Phenylalanine Hydroxylase Regulatory Domain.
Sci.Rep., 6, 2016
4UYI
  • Download 4uyi
  • View 4uyi
Molmil generated image of 4uyi
CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN SLX4 (BTBD12)
Descriptor:STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4
Authors:Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-09-01
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure of the Btb Domain of Human Slx4 (Btbd12)
To be Published
4UNO
  • Download 4uno
  • View 4uno
Molmil generated image of 4uno
CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETV5 IN COMPLEX WITH DNA
Descriptor:ETS TRANSLOCATION VARIANT 5, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3', ...
Authors:Newman, J.A., Aitkenhead, H., Cooper, C.D.O., Pinkas, D.M., Shrestha, L., Burgess-Brown, N., Kopec, J., Fitzpatrick, F., Tallant, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2014-05-29
Release date:2014-06-11
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
5NFJ
  • Download 5nfj
  • View 5nfj
Molmil generated image of 5nfj
CRYSTAL STRUCTURE OF THE METHYLTRANSFERASE SUBUNIT OF HUMAN MITOCHONDRIAL RIBONUCLEASE P (MRPP1) BOUND TO S-ADENOSYL-METHIONINE (SAM)
Descriptor:Mitochondrial ribonuclease P protein 1, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:Oerum, S., Kopec, J., Fitzpatrick, F., Newman, J.A., Chalk, R., Shrestha, L., Fairhead, M., Talon, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, C., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2017-03-14
Release date:2018-05-16
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM)
To Be Published
4COO
  • Download 4coo
  • View 4coo
Molmil generated image of 4coo
CRYSTAL STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE (DELTA516-525) AT 2.0 ANGSTROM RESOLUTION
Descriptor:CYSTATHIONINE BETA-SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:McCorvie, T.J., Kopec, J., Vollamar, M., Strain-Damerell, C., Bushell, S., Bradley, A., Tallant, C., Kiyani, W., Froese, D.S., Carpenter, E.S., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-01-29
Release date:2014-03-05
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
5A4R
  • Download 5a4r
  • View 5a4r
Molmil generated image of 5a4r
CRYSTAL STRUCTURE OF A VITAMIN B12 TRAFFICKING PROTEIN
Descriptor:METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE D HOMOLOG, MITOCHONDRIAL
Authors:Kopec, J., Fitzpatrick, F., Froese, D.S., Velupillai, S., Nowak, R., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Fowler, B., Baumgartner, M.R., Yue, W.W.
Deposit date:2015-06-11
Release date:2015-10-28
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Insights Into the Mmachc-Mmadhc Protein Complex Involved in Vitamin B12 Trafficking.
J.Biol.Chem., 290, 2015
5MYG
  • Download 5myg
  • View 5myg
Molmil generated image of 5myg
CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH NI-57 CHEMICAL PROBE
Descriptor:Peregrin, 4-cyano-~{N}-(1,3-dimethyl-2-oxidanylidene-quinolin-6-yl)-2-methoxy-benzenesulfonamide
Authors:Tallant, C., Igoe, N., Bayle, E.D., Krojer, T., Nunez-Alonso, G., Kopec, J., Fitzpatrick, F., Savitsky, P., Fedorov, O., Brennan, P.E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Fish, P., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2017-01-26
Release date:2017-08-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
J. Med. Chem., 60, 2017
5MPO
  • Download 5mpo
  • View 5mpo
Molmil generated image of 5mpo
CRYSTAL STRUCTURE OF HUMAN MOLYBDOPTERIN SYNTHASE COMPLEX
Descriptor:Molybdopterin synthase sulfur carrier subunit, Molybdopterin synthase catalytic subunit
Authors:Kopec, J., Bailey, H., Fitzpatrick, F., Strain-Damerell, C., Oberholzer, A.E., Williams, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2016-12-16
Release date:2016-12-28
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Crystal structure of human molybdopterin synthase complex
To Be Published
4V06
  • Download 4v06
  • View 4v06
Molmil generated image of 4v06
CRYSTAL STRUCTURE OF HUMAN TRYPTOPHAN HYDROXYLASE 2 (TPH2), CATALYTIC DOMAIN
Descriptor:TRYPTOPHAN 5-HYDROXYLASE 2, IMIDAZOLE, FE (III) ION
Authors:Kopec, J., Oberholzer, A., Fitzpatrick, F., Newman, J., Tallant, C., Kiyani, W., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-09-11
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
To be Published
5FTA
  • Download 5fta
  • View 5fta
Molmil generated image of 5fta
CRYSTAL STRUCTURE OF THE N-TERMINAL BTB DOMAIN OF HUMAN KCTD10
Descriptor:BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 3, MERCURY (II) ION
Authors:Pinkas, D.M., Sanvitale, C.E., Solcan, N., Goubin, S., Tallant, C., Newman, J.A., Kopec, J., Fitzpatrick, F., Talon, R., Collins, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2016-01-12
Release date:2016-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
5ACB
  • Download 5acb
  • View 5acb
Molmil generated image of 5acb
CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLINK COMPLEX
Descriptor:CYCLIN-K, CYCLIN-DEPENDENT KINASE 12, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide
Authors:Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Mackenzie, A., Goubin, S., Strain-Damerell, C., Mahajan, P., Tallant, C., Chalk, R., Wiggers, H., Kopec, J., Fitzpatrick, F., Burgess-Brown, N., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-08-14
Release date:2016-06-15
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Covalent Targeting of Remote Cysteine Residues to Develop Cdk12 and Cdk13 Inhibitors.
Nat.Chem.Biol., 12, 2016
5A15
  • Download 5a15
  • View 5a15
Molmil generated image of 5a15
CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN KCTD16
Descriptor:BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD16
Authors:Pinkas, D.M., Sanvitale, C.E., Solcan, N., Goubin, S., Canning, P., Dixon Clarke, S.E., Talon, R., Wiggers, H.J., Fitzpatrick, F., Tallant, C., Kopec, J., Chalk, R., Doutch, J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-04-28
Release date:2015-11-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017