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1XV8
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CRYSTAL STRUCTURE OF HUMAN SALIVARY ALPHA-AMYLASE DIMER
Descriptor:Alpha-amylase, CALCIUM ION, CHLORIDE ION
Authors:Fisher, S.Z., Govindasamy, L., Tu, C.K., Silverman, D.N., Rajaniemi, H., McKenna, R.
Deposit date:2004-10-27
Release date:2005-10-11
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Salivary Alpha-Amylase Dimer
To be Published
2EU2
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, (R)-1-AMINO-1-[5-(DIMETHYLAMINO)-1,3,4-THIADIAZOL-2-YL]METHANESULFONAMIDE
Authors:Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
Deposit date:2005-10-28
Release date:2006-07-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006
2EU3
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1,1-DIFLUOROMETHANESULFONAMIDE
Authors:Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
Deposit date:2005-10-28
Release date:2006-07-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006
2ILI
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REFINE ATOMIC STRUCTURE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z.
Deposit date:2006-10-02
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism
Biochemistry, 46, 2007
2NWO
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STRUCTURAL AND KINETIC EFFECT OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWP
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWY
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS ON THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWZ
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS ON THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXR
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STRUCTURAL EFFECTS OF HYDROPHOBIC MUTATIONS ON THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXS
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXT
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2QWS
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NEUTRON AND X-RAY STRUCTURAL STUDIES OF SHORT HYDROGEN BONDS IN PHOTOACTIVE YELLOW PROTEIN (PYP)
Descriptor:Photoactive yellow protein, 4'-HYDROXYCINNAMIC ACID
Authors:Fisher, S.Z., Langan, P.
Deposit date:2007-08-10
Release date:2008-03-18
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Neutron and X-ray structural studies of short hydrogen bonds in photoactive yellow protein (PYP)
Acta Crystallogr.,Sect.D, 63, 2007
3KKX
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NEUTRON STRUCTURE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., Langan, P.A.
Deposit date:2009-11-06
Release date:2010-01-12
Last modified:2018-06-20
Method:NEUTRON DIFFRACTION (2 Å)
Cite:Neutron structure of human carbonic anhydrase II: implications for proton transfer.
Biochemistry, 49, 2010
4G0C
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NEUTRON STRUCTURE OF ACETAZOLAMIDE-BOUND HUMAN CARBONIC ANHYDRASE II REVEAL MOLECULAR DETAILS OF DRUG BINDING.
Descriptor:Carbonic anhydrase 2, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
Authors:Fisher, S.Z., McKenna, R., Aggarwal, M.
Deposit date:2012-07-09
Release date:2012-09-19
Last modified:2018-04-25
Method:NEUTRON DIFFRACTION (2 Å)
Cite:Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.
J.Am.Chem.Soc., 134, 2012
4N0X
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ROOM TEMPERATURE CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THIOPHENE-2-SULFONAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, thiophene-2-sulfonamide
Authors:Fisher, S.Z., Williams, R.F.
Deposit date:2013-10-02
Release date:2014-01-29
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide
To be Published
4Q49
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ROOM TEMPERATURE NEUTRON CRYSTAL STRUCTURE OF APO HUMAN CARBONIC ANHYDRASE AT PH 7.5
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2014-04-14
Release date:2015-02-25
Last modified:2018-06-13
Method:NEUTRON DIFFRACTION (1.8 Å)
Cite:Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer.
Proc.Natl.Acad.Sci.USA, 112, 2015
4Y0J
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H/D EXCHANGED HUMAN CARBONIC ANHYDRASE II PH 6 ROOM TEMPERATURE NEUTRON CRYSTAL STRUCTURE.
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z.
Deposit date:2015-02-06
Release date:2015-04-22
Last modified:2018-11-14
Method:NEUTRON DIFFRACTION (2 Å)
Cite:Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer.
Proc.Natl.Acad.Sci.USA, 112, 2015
6FJI
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JOINT NEUTRON AND X-RAY CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX MIMIC (APO).
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z.
Deposit date:2018-01-22
Release date:2019-02-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å), NEUTRON DIFFRACTION
Cite:Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.
J. Struct. Biol., 205, 2019
6FJJ
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JOINT NEUTRON AND X-RAY CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX MIMIC (SACCHARIN).
Descriptor:Carbonic anhydrase 2, ZINC ION, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE
Authors:Fisher, S.Z.
Deposit date:2018-01-22
Release date:2019-02-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.5 Å), NEUTRON DIFFRACTION
Cite:Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.
J. Struct. Biol., 205, 2019
6GCY
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JOINT NEUTRON AND X-RAY CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX MIMIC (SACCHARIN-SUGAR CONJUGATE COMPLEX)
Descriptor:Carbonic anhydrase 2, ZINC ION, [1-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzothiazol-6-yl)-1H-1,2,3-triazol-4-yl]methyl alpha-L-idopyranoside
Authors:Fisher, S.Z., Koruza, K.
Deposit date:2018-04-20
Release date:2019-02-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.3 Å), NEUTRON DIFFRACTION
Cite:Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.
J. Struct. Biol., 205, 2019
1YO0
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PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, CHLORIDE ION
Authors:Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
1YO1
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PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, SULFATE ION, ZINC ION
Authors:Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
1YO2
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PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
1Z93
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HUMAN CARBONIC ANHYDRASE III:STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
Descriptor:Carbonic anhydrase III, ZINC ION
Authors:Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
Deposit date:2005-03-31
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
1Z97
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HUMAN CARBONIC ANHYDRASE III: STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
Descriptor:Carbonic anhydrase III, ZINC ION
Authors:Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
Deposit date:2005-03-31
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005