Author results

5OOU
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DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) YTRL-1 SELECTED BY DIRECTED EVOLUTION AGAINST LYSOZYME
Descriptor:DARPin YTRL-1
Authors:Fischer, G., Hogan, B.J., Houlihan, G., Edmond, S., Huovinen, T.T.K., Hollfelder, F., Hyvonen, M.
Deposit date:2017-08-08
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Designed Ankyrin Repeat Protein (DARPin) YTRL-1 selected by directed evolution against Lysozyme
To be published
5OP1
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DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) A4 IN COMPLEX WITH LYSOZYME
Descriptor:DARPin A4, Lysozyme C, CHLORIDE ION
Authors:Fischer, G., Hogan, B.J., Houlihan, G., Edmond, S., Huovinen, T.T.K., Hollfelder, F., Hyvonen, M.
Deposit date:2017-08-09
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.284 Å)
Cite:Designed Ankyrin Repeat Protein (DARPin) A4 in complex with Lysozyme
To be published
5OP3
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DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) NDNH-1 SELECTED BY DIRECTED EVOLUTION AGAINST LYSOZYME
Descriptor:DARPin NDNH-1, ACETATE ION, CALCIUM ION, ...
Authors:Fischer, G., Hogan, B.J., Houlihan, G., Edmond, S., Huovinen, T.T.K., Hollfelder, F., Hyvonen, M.
Deposit date:2017-08-09
Release date:2018-08-29
Method:X-RAY DIFFRACTION (1.359 Å)
Cite:Designed Ankyrin Repeat Protein (DARPin) NDNH-1 selected by directed evolution against Lysozyme
To be published
2W1P
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1.4 ANGSTROM CRYSTAL STRUCTURE OF P.PASTORIS AQUAPORIN, AQY1, IN A CLOSED CONFORMATION AT PH 8.0
Descriptor:AQUAPORIN PIP2-7 7;, B-OCTYLGLUCOSIDE, CHLORIDE ION
Authors:Fischer, G., Kosinska-Eriksson, U., Aponte-Santamaria, C., Palmgren, M., Geijer, C., Hedfalk, K., Hohmann, S., de Groot, B.L., Neutze, R., Lindkvist-Petersson, K.
Deposit date:2008-10-20
Release date:2009-06-16
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of a Yeast Aquaporin at 1.15 A Reveals a Novel Gating Mechanism
Plos Biol., 7, 2009
2W2E
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1.15 ANGSTROM CRYSTAL STRUCTURE OF P.PASTORIS AQUAPORIN, AQY1, IN A CLOSED CONFORMATION AT PH 3.5
Descriptor:AQUAPORIN PIP2-7 7, B-OCTYLGLUCOSIDE, CHLORIDE ION
Authors:Fischer, G., Kosinska-Eriksson, U., Aponte-Santamaria, C., Palmgren, M., Geijer, C., Hedfalk, K., Hohmann, S., de Groot, B.L., Neutze, R., Lindkvist-Petersson, K.
Deposit date:2008-10-29
Release date:2009-06-16
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystal Structure of a Yeast Aquaporin at 1.15 A Reveals a Novel Gating Mechanism.1.15 A
Plos Biol., 7, 2009
5BN2
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ROOM TEMPERATURE STRUCTURE OF PICHIA PASTORIS AQUAPORIN AT 1.3 A
Descriptor:AQY1 protein, B-OCTYLGLUCOSIDE, CHLORIDE ION, ...
Authors:Fischer, G., Kosinska Eriksson, U., Hedfalk, K., Neutze, R.
Deposit date:2015-05-25
Release date:2016-06-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Room Temperature Structure of Pichia pastoris aquaporin at 1.3 A
To Be Published
5JFG
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STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F IN COMPLEX WITH PEPTIDE FHTA
Descriptor:DNA repair and recombination protein RadA, PEPTIDE FHTA, DIMETHYL SULFOXIDE, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-19
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Humanisation of RadA from Pyrococcus furiosus
To Be Published
5OOS
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DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) YTRL-2 SELECTED BY DIRECTED EVOLUTION AGAINST LYSOZYME
Descriptor:DARPin YTRL-2, CHLORIDE ION, NONAETHYLENE GLYCOL
Authors:Hogan, B.J., Fischer, G., Houlihan, G., Edmond, S., Huovinen, T.T.K., Hollfelder, F., Hyvonen, M.
Deposit date:2017-08-08
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Designed Ankyrin Repeat Protein (DARPin) YTRL-2 selected by directed evolution against Lysozyme
To be published
5OOV
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DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) ETVD-1 IN COMPLEX WITH LYSOZYME
Descriptor:DARPin ETVD-1, Lysozyme C
Authors:Houlihan, G., Fischer, G., Hogan, B.J., Edmond, S., Huovinen, T.T.K., Hollfelder, F., Hyvonen, M.
Deposit date:2017-08-08
Release date:2018-08-29
Method:X-RAY DIFFRACTION (1.365 Å)
Cite:Designed Ankyrin Repeat Protein (DARPin) ETVD-1 in complex with Lysozyme
To be published
4UPH
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CRYSTAL STRUCTURE OF PHOSPHONATE MONOESTER HYDROLASE OF AGROBACTERIUM RADIOBACTER
Descriptor:SULFATASE (SULFURIC ESTER HYDROLASE) PROTEIN, MAGNESIUM ION, CHLORIDE ION
Authors:Fischer, G., Loo, B.v., Hyvonen, M., Hollfelder, F.
Deposit date:2014-06-17
Release date:2015-07-01
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
J. Am. Chem. Soc., 2018
5J4H
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STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F IN COMPLEX WITH INDOLE-6-CARBOXYLIC ACID
Descriptor:DNA repair and recombination protein RadA, 1H-indole-6-carboxylic acid, SODIUM ION, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-01
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.374 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5J4K
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STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F IN COMPLEX WITH 1-INDANE-6-CARBOXYLIC ACID
Descriptor:DNA repair and recombination protein RadA, SODIUM ION, CALCIUM ION, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-01
Release date:2016-10-26
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.346 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5J4L
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F
Descriptor:DNA repair and recombination protein RadA, CHLORIDE ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-01
Release date:2016-10-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5JEC
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA33F
Descriptor:DNA repair and recombination protein RadA, CHLORIDE ION, SULFATE ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-18
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5JED
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA28
Descriptor:DNA repair and recombination protein RadA, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-18
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.332 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5JEE
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA26F
Descriptor:DNA repair and recombination protein RadA, CALCIUM ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-18
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5KDD
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22
Descriptor:DNA repair and recombination protein RadA, SULFATE ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-06-08
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5NIR
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CRYSTAL STRUCTURE OF COLLAGEN 2A VWC DOMAIN
Descriptor:Collagen alpha-1(II) chain, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Fischer, G., Blythe, E., Hyvonen, M.
Deposit date:2017-03-27
Release date:2017-06-14
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.
J. Biol. Chem., 292, 2017
1FD9
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CRYSTAL STRUCTURE OF THE MACROPHAGE INFECTIVITY POTENTIATOR PROTEIN (MIP) A MAJOR VIRULENCE FACTOR FROM LEGIONELLA PNEUMOPHILA
Descriptor:PROTEIN (MACROPHAGE INFECTIVITY POTENTIATOR PROTEIN), ZINC ION
Authors:Riboldi-Tunnicliffe, A., Jessen, S., Konig, B., Rahfeld, J., Hacker, J., Fischer, G., Hilgenfeld, R.
Deposit date:2000-07-20
Release date:2001-07-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal structure of Mip, a prolylisomerase from Legionella pneumophila
Nat.Struct.Biol., 8, 2001
3ZOJ
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HIGH-RESOLUTION STRUCTURE OF PICHIA PASTORIS AQUAPORIN AQY1 AT 0.88 A
Descriptor:AQUAPORIN, B-OCTYLGLUCOSIDE, CHLORIDE ION
Authors:Kosinska-Eriksson, U., Fischer, G., Friemann, R., Enkavi, G., Tajkhorshid, E., Neutze, R.
Deposit date:2013-02-21
Release date:2013-06-26
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (0.88 Å)
Cite:Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions
Science, 340, 2013
1EQ3
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NMR STRUCTURE OF HUMAN PARVULIN HPAR14
Descriptor:PEPTIDYL-PROLYL CIS/TRANS ISOMERASE (PPIASE)
Authors:Sekerina, E., Rahfeld, U.J., Muller, J., Fischer, G., Bayer, P.
Deposit date:2000-04-02
Release date:2001-04-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein.
J.Mol.Biol., 301, 2000
1JNS
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NMR STRUCTURE OF THE E. COLI PEPTIDYL-PROLYL CIS/TRANS-ISOMERASE PARVULIN 10
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C
Authors:Kuehlewein, A., Voll, G., Schelbert, B., Kessler, H., Fischer, G., Rahfeld, J.U., Gemmecker, G.
Deposit date:2001-07-25
Release date:2003-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases.
Protein Sci., 13, 2004
1JNT
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NMR STRUCTURE OF THE E. COLI PEPTIDYL-PROLYL CIS/TRANS-ISOMERASE PARVULIN 10
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C
Authors:Kuehlewein, A., Voll, G., Schelbert, B., Kessler, H., Fischer, G., Rahfeld, J.U., Gemmecker, G.
Deposit date:2001-07-25
Release date:2003-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases.
Protein Sci., 13, 2004
3EY6
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CRYSTAL STRUCTURE OF THE FK506-BINDING DOMAIN OF HUMAN FKBP38
Descriptor:FK506-binding protein 8
Authors:Parthier, C., Maestre-Martinez, M., Neumann, P., Edlich, F., Fischer, G., Luecke, C., Stubbs, M.T.
Deposit date:2008-10-19
Release date:2009-10-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.
J.Mol.Recognit., 24, 2011
4JA7
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RAT PP5 CO-CRYSTALLIZED WITH P5SA-2
Descriptor:Serine/threonine-protein phosphatase 5, MAGNESIUM ION
Authors:Haslbeck, V., Helmuth, M., Alte, F., Popowicz, G., Schmidt, W., Weiwad, M., Fischer, G., Gemmecker, G., Sattler, M., Striggow, F., Groll, M., Richter, K.
Deposit date:2013-02-18
Release date:2014-02-19
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci.Rep., 35, 2015
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