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2CCY
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STRUCTURE OF FERRICYTOCHROME C(PRIME) FROM RHODOSPIRILLUM MOLISCHIANUM AT 1.67 ANGSTROMS RESOLUTION
Descriptor:CYTOCHROME C, PROTOPORPHYRIN IX CONTAINING FE
Authors:Finzel, B.C., Weber, P.C., Hardman, K.D., Salemme, F.R.
Deposit date:1985-08-27
Release date:1986-01-21
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure of ferricytochrome c' from Rhodospirillum molischianum at 1.67 A resolution.
J.Mol.Biol., 186, 1985
2CYP
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CRYSTAL STRUCTURE OF YEAST CYTOCHROME C PEROXIDASE REFINED AT 1.7-ANGSTROMS RESOLUTION
Descriptor:CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, OXYGEN ATOM
Authors:Finzel, B.C., Poulos, T.L., Kraut, J.
Deposit date:1985-08-27
Release date:1986-01-21
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of yeast cytochrome c peroxidase refined at 1.7-A resolution
J.Biol.Chem., 259, 1984
1I1B
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-1BETA AT 2.0 ANGSTROMS RESOLUTION
Descriptor:INTERLEUKIN-1 BETA
Authors:Finzel, B.C., Watenpaugh, K.D., Einspahr, H.M.
Deposit date:1989-12-05
Release date:1990-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of recombinant human interleukin-1 beta at 2.0 A resolution.
J.Mol.Biol., 209, 1989
1USN
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Finzel, B.C., Bryant Junior, G.L., Baldwin, E.T.
Deposit date:1998-06-09
Release date:1998-12-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.
Protein Sci., 7, 1998
2USN
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-141803
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Finzel, B.C., Bryant Junior, G.L., Baldwin, E.T.
Deposit date:1998-06-09
Release date:1998-12-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.
Protein Sci., 7, 1998
4BP2
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CRYSTALLOGRAPHIC REFINEMENT OF BOVINE PRO-PHOSPHOLIPASE A2 AT 1.6 ANGSTROMS RESOLUTION
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Finzel, B.C., Weber, P.C., Ohlendorf, D.H., Salemme, F.R.
Deposit date:1990-09-07
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic refinement of bovine pro-phospholipase A2 at 1.6 A resolution.
Acta Crystallogr.,Sect.B, 47, 1991
4P2P
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AN INDEPENDENT CRYSTALLOGRAPHIC REFINEMENT OF PORCINE PHOSPHOLIPASE A2 AT 2.4 ANGSTROMS RESOLUTION
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Finzel, B.C., Ohlendorf, D.H., Weber, P.C., Salemme, F.R.
Deposit date:1991-10-22
Release date:1992-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An independent crystallographic refinement of porcine phospholipase A2 at 2.4 A resolution
Acta Crystallogr.,Sect.B, 47, 1991
4XJM
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH A HTS LEAD COMPOUND
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 3-{1-[(5-acetylthiophen-2-yl)carbonyl]piperidin-4-yl}-N-(3-methoxyphenyl)propanamide, PYRIDOXAL-5'-PHOSPHATE
Authors:Finzel, B.C., Dai, R.
Deposit date:2015-01-08
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Fragment based inhibitor design of Mycobacterium tuberculosis BioA (http://hdl.handle.net/11299/171084)
Thesis, University of Minnesota, 2015
1RDH
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CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (RIBONUCLEASE H DOMAIN)
Authors:Finzel, B.C., Chattopadhyay, D., Einspahr, H.M.
Deposit date:1993-03-05
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic analyses of an active HIV-1 ribonuclease H domain show structural features that distinguish it from the inactive form.
Acta Crystallogr.,Sect.D, 49, 1993
2IRT
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INITIAL CRYSTALLOGRAPHIC ANALYSES OF A RECOMBINANT INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN
Descriptor:INTERLEUKIN-1 RECEPTOR ANTAGONIST
Authors:Finzel, B.C., Clancy, L.L., Einspahr, H.M.
Deposit date:1994-07-13
Release date:1994-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Initial crystallographic analysis of a recombinant human interleukin-1 receptor antagonist protein.
Acta Crystallogr.,Sect.D, 50, 1994
4MQP
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MYCOBATERIUM TUBERCULOSIS TRANSAMINASE BIOA COMPLEXED WITH 2-HYDRAZINYLBENZO[D]THIAZOLE
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, (4-{[(E)-1,3-benzothiazol-2-yldiazenyl]methyl}-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate, 1,2-ETHANEDIOL, ...
Authors:Finzel, B.C., Dai, R.
Deposit date:2013-09-16
Release date:2014-03-05
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides.
Chembiochem, 15, 2014
4MQQ
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MYCOBATERIUM TUBERCULOSIS TRANSAMINASE BIOA COMPLEXED WITH BENZO[D]THIAZOLE-2-CARBOHYDRAZIDE
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Finzel, B.C., Dai, R.
Deposit date:2013-09-16
Release date:2014-03-05
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides.
Chembiochem, 15, 2014
4MQR
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MYCOBATERIUM TUBERCULOSIS TRANSAMINASE BIOA COMPLEXED WITH E)-5-HYDROXY-4-(((Z)-ISONICOTINOYLDIAZENYL)METHYLENE)-6-METHYL-1,4-DIHYDROPYRIDIN-3-YL)METHYL PHOSPHATE
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, [(4Z)-5-hydroxy-6-methyl-4-{[(E)-(pyridin-4-ylcarbonyl)diazenyl]methylidene}-1,4-dihydropyridin-3-yl]methyl dihydrogen phosphate, 1,2-ETHANEDIOL
Authors:Finzel, B.C., Dai, R.
Deposit date:2013-09-16
Release date:2014-03-05
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides.
Chembiochem, 15, 2014
4W1V
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH A THIAZOLE INHIBITOR
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, dimethyl (2R)-5-(3-fluorophenyl)-1H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate 2-oxide, ...
Authors:Finzel, B.C., Dai, R.
Deposit date:2014-08-13
Release date:2015-02-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis.
Chem.Biol., 22, 2015
4W1W
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH 7-(DIETHYLAMINO)-3-(THIOPHENE-2-CARBONYL)-2H-CHROMEN-2-ONE
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 7-(diethylamino)-3-(thiophen-2-ylcarbonyl)-2H-chromen-2-one, ...
Authors:Finzel, B.C., Ran, D.
Deposit date:2014-08-13
Release date:2015-02-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis.
Chem.Biol., 22, 2015
4W1X
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH 1-(4-(4-(3-CHLOROBENZOYL)PIPERAZIN-1-YL)PHENYL)ETHANONE
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 1,2-ETHANEDIOL, ...
Authors:Finzel, B.C., Dai, R.
Deposit date:2014-08-13
Release date:2015-02-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis.
Chem.Biol., 22, 2015
4WYA
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH A FRAGMENT HIT
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 5-(pyridin-2-yl)thiophene-2-carboxamide
Authors:Finzel, B.C., Dai, D., Geders, T.W.
Deposit date:2014-11-17
Release date:2015-07-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA.
J.Med.Chem., 58, 2015
4WYC
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH A THIAZOLE BENZAMIDE INHIBITOR
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 4-(1H-imidazol-1-yl)benzamide, ...
Authors:Finzel, B.C., Dai, R., Geders, T.W.
Deposit date:2014-11-17
Release date:2015-07-08
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA.
J.Med.Chem., 58, 2015
4XEW
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH A HTS LEAD COMPOUND
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 6-(2-fluorophenyl)[1,3]dioxolo[4,5-g]quinolin-8(5H)-one
Authors:Finzel, B.C., Dai, R.
Deposit date:2014-12-25
Release date:2015-07-08
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA.
J.Med.Chem., 58, 2015
4XJO
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH AN INHIBITOR OPTIMIZED FROM HTS LEAD
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 5-[4-(3-chlorobenzoyl)piperazin-1-yl]-1H-inden-1-one, ...
Authors:Finzel, B.C., Dai, R.
Deposit date:2015-01-08
Release date:2016-01-20
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
J. Med. Chem., 60, 2017
4XJP
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CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE (BIOA) FROM MYCOBACTERIUM TUBERCULOSIS, COMPLEXED WITH AN INHIBITOR OPTIMIZED FROM HTS LEAD
Descriptor:Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 1-{4-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]phenyl}ethanone, ...
Authors:Finzel, B.C., Dai, R.
Deposit date:2015-01-08
Release date:2016-01-20
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
J. Med. Chem., 60, 2017
1Z4U
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH INHIBITOR PHA-00799585
Descriptor:HCV NS5B POLYMERASE, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Pfefferkorn, J.A., Greene, M., Nugent, R., Gross, R.J., Mitchell, M.A., Finzel, B.C., Harris, M.S., Wells, P.A., Shelly, J.A., Anstadt, R.
Deposit date:2005-03-16
Release date:2005-06-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid
Bioorg.Med.Chem.Lett., 15, 2005
4XTU
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MYCOBACTERIUM TUBERCULOSIS BIOTIN LIGASE COMPLEXED WITH BISUBSTRATE INHIBITOR (N-({[(1R,2S,3R,4R)-4-(6-AMINO-9H-PURIN-9-YL)-2,3-DIHYDROXYCYCLOPENTYL]METHYL}SULFAMOYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE)
Descriptor:Bifunctional ligase/repressor BirA, N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Authors:De la Mora-Rey, T., Finzel, B.C.
Deposit date:2015-01-24
Release date:2016-01-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.65003 Å)
Cite:Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor (N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide)
To be Published
1FIX
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THE STRUCTURE OF AN RNA/DNA HYBRID: A SUBSTRATE OF THE RIBONUCLEASE ACTIVITY OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor:RNA (5'-R(*UP*UP*CP*GP*GP*GP*CP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*GP*CP*CP*CP*GP*AP*A)-3')
Authors:Horton, N.C., Finzel, B.C.
Deposit date:1996-10-24
Release date:1996-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of an RNA/DNA hybrid: a substrate of the ribonuclease activity of HIV-1 reverse transcriptase.
J.Mol.Biol., 264, 1996
1PPA
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THE CRYSTAL STRUCTURE OF A LYSINE 49 PHOSPHOLIPASE A2 FROM THE VENOM OF THE COTTONMOUTH SNAKE AT 2.0 ANGSTROMS RESOLUTION
Descriptor:PHOSPHOLIPASE A2, ANILINE
Authors:Holland, D.R., Clancy, L.L., Muchmore, S.W., Rydel, T.J., Einspahr, H.M., Finzel, B.C., Heinrikson, R.L., Watenpaugh, K.D.
Deposit date:1991-10-29
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of a lysine 49 phospholipase A2 from the venom of the cottonmouth snake at 2.0-A resolution.
J.Biol.Chem., 265, 1990