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5LNK
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BU of 5lnk by Molmil
Entire ovine respiratory complex I
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 4'-PHOSPHOPANTETHEINE, ...
Authors:Fiedorczuk, K, Letts, J.A, Kaszuba, K, Sazanov, L.A.
Deposit date:2016-08-04
Release date:2016-11-23
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Atomic structure of the entire mammalian mitochondrial complex I.
Nature, 538, 2016
7SV7
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BU of 7sv7 by Molmil
The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Tezacaftor (VX-661)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Cystic fibrosis transmembrane conductance regulator, ...
Authors:Fiedorczuk, K, Chen, J.
Deposit date:2021-11-18
Release date:2022-01-12
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Mechanism of CFTR correction by type I folding correctors.
Cell, 185, 2022
7SVR
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BU of 7svr by Molmil
The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) and Lumacaftor (VX-809)
Descriptor: Cystic fibrosis transmembrane conductance regulator, Lumacaftor
Authors:Fiedorczuk, K, Chen, J.
Deposit date:2021-11-19
Release date:2022-01-12
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of CFTR correction by type I folding correctors.
Cell, 185, 2022
7SVD
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BU of 7svd by Molmil
The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Lumacaftor (VX-809)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Cystic fibrosis transmembrane conductance regulator, ...
Authors:Fiedorczuk, K, Chen, J.
Deposit date:2021-11-18
Release date:2022-01-12
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanism of CFTR correction by type I folding correctors.
Cell, 185, 2022
8EJ1
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BU of 8ej1 by Molmil
Dephosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)
Descriptor: Cystic fibrosis transmembrane conductance regulator
Authors:Fiedorczuk, K, Chen, J.
Deposit date:2022-09-16
Release date:2022-10-19
Last modified:2022-11-09
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
8EIO
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BU of 8eio by Molmil
The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg
Descriptor: (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
Authors:Fiedorczuk, K, Chen, J.
Deposit date:2022-09-15
Release date:2022-10-19
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
8EIQ
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BU of 8eiq by Molmil
The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg
Descriptor: (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
Authors:Fiedorczuk, K, Chen, J.
Deposit date:2022-09-15
Release date:2022-10-19
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
8EIG
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BU of 8eig by Molmil
The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg
Descriptor: (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
Authors:Fiedorczuk, K, Chen, J.
Deposit date:2022-09-15
Release date:2022-10-19
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
8UBR
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BU of 8ubr by Molmil
Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Young, P.G, Fiedorczuk, K, Chen, J.
Deposit date:2023-09-24
Release date:2024-02-21
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for CFTR inhibition by CFTR inh -172.
Proc.Natl.Acad.Sci.USA, 121, 2024
4WT8
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BU of 4wt8 by Molmil
Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex
Descriptor: 23S rRNA (2899-MER), 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Amunts, A, Fiedorczuk, K, Ramakrishnan, V.
Deposit date:2014-10-29
Release date:2015-01-21
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics.
J.Mol.Biol., 427, 2015
5J4Z
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BU of 5j4z by Molmil
Architecture of tight respirasome
Descriptor: COMPLEX I 13KDA/NDUFS6, COMPLEX I 15KDA/NDUFS5, COMPLEX I 18KDA/NDUFS6, ...
Authors:Letts, J.A, Fiedorczuk, K, Sazanov, L.A.
Deposit date:2016-04-01
Release date:2016-09-21
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:The architecture of respiratory supercomplexes.
Nature, 537, 2016
5J8K
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BU of 5j8k by Molmil
Architecture of supercomplex I-III2
Descriptor: COMPLEX I 13KDA/NDUFS6, COMPLEX I 15KDA/NDUFS5, COMPLEX I 18KDA/NDUFS6, ...
Authors:Letts, J.A, Fiedorczuk, K, Sazanov, L.A.
Deposit date:2016-04-08
Release date:2016-09-21
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:The architecture of respiratory supercomplexes.
Nature, 537, 2016
5J7Y
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BU of 5j7y by Molmil
Architecture of loose respirasome
Descriptor: COMPLEX I 13KDA/NDUFS6, COMPLEX I 15KDA/NDUFS5, COMPLEX I 18KDA/NDUFS6, ...
Authors:Letts, J.A, Fiedorczuk, F, Sazanov, L.A.
Deposit date:2016-04-07
Release date:2016-09-21
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:The architecture of respiratory supercomplexes.
Nature, 537, 2016
6Q9B
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BU of 6q9b by Molmil
CI Membrane Arm focused refinement from Ovine respiratory SC I+III2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-17
Release date:2019-08-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QA9
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BU of 6qa9 by Molmil
Isolated complex I class refinement from Ovine respiratory supercomplex I+III2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-19
Release date:2019-08-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QC8
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BU of 6qc8 by Molmil
Ovine respiratory complex I FRC open class 2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-27
Release date:2019-08-21
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QC7
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BU of 6qc7 by Molmil
Ovine respiratory complex I FRC open class 3
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-27
Release date:2019-08-21
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6Q9E
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BU of 6q9e by Molmil
Complex III2 focused refinement from Ovine respiratory supercomplex I+III2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CARDIOLIPIN, Cytochrome b, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-18
Release date:2019-08-21
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6Q9D
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BU of 6q9d by Molmil
CI Peripheral Arm focused refinement from Ovine respiratory SC I+III2
Descriptor: Acyl carrier protein, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-18
Release date:2019-08-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QBX
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BU of 6qbx by Molmil
Ovine respiratory supercomplex I+III2 closed class.
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-24
Release date:2019-08-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QC4
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BU of 6qc4 by Molmil
Ovine respiratory supercomplex I+III2 open class 3
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Acyl carrier protein, Cytochrome b, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-26
Release date:2019-08-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QC5
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BU of 6qc5 by Molmil
Ovine respiratory complex I FRC closed class 1
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-26
Release date:2019-08-21
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QCF
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BU of 6qcf by Molmil
Ovine respiratory complex I FRC open class 6
Descriptor: Acyl carrier protein, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-27
Release date:2019-08-21
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QC2
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BU of 6qc2 by Molmil
Ovine respiratory supercomplex I+III2 open class 2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-26
Release date:2019-08-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019
6QC6
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BU of 6qc6 by Molmil
Ovine respiratory complex I FRC open class 1
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ...
Authors:Letts, J.A, Sazanov, L.A.
Deposit date:2018-12-27
Release date:2019-08-21
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk.
Mol.Cell, 75, 2019

 

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PDB entries from 2024-03-27

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