Author results

1BI5
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CHALCONE SYNTHASE FROM ALFALFA
Descriptor:CHALCONE SYNTHASE
Authors:Ferrer, J.L., Jez, J.M., Bowman, M.E., Dixon, R.A., Noel, J.P.
Deposit date:1998-06-22
Release date:1999-06-22
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.
Nat.Struct.Biol., 6, 1999
1D6F
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CHALCONE SYNTHASE C164A MUTANT
Descriptor:CHALCONE SYNTHASE, SULFATE ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., Noel, J.P.
Deposit date:1999-10-13
Release date:2000-02-03
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.
Biochemistry, 39, 2000
1D6H
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CHALONE SYNTHASE (N336A MUTANT COMPLEXED WITH COA)
Descriptor:CHALCONE SYNTHASE, SULFATE ION, COENZYME A
Authors:Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., Noel, J.P.
Deposit date:1999-10-13
Release date:2000-02-03
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.
Biochemistry, 39, 2000
1D6I
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CHALCONE SYNTHASE (H303Q MUTANT)
Descriptor:CHALCONE SYNTHASE, SULFATE ION
Authors:Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., Noel, J.P.
Deposit date:1999-10-13
Release date:2000-02-03
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.
Biochemistry, 39, 2000
1DDG
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CRYSTAL STRUCTURE OF SIR-FP60
Descriptor:SULFITE REDUCTASE (NADPH) FLAVOPROTEIN ALPHA-COMPONENT, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
Authors:Gruez, A., Pignol, D., Zeghouf, M., Coves, J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps, J.C.
Deposit date:1999-11-10
Release date:2000-11-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.
J.Mol.Biol., 299, 2000
1DDI
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CRYSTAL STRUCTURE OF SIR-FP60
Descriptor:SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Gruez, A., Pignol, D., Zeghouf, M., Coves, J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps, J.C.
Deposit date:1999-11-10
Release date:2000-11-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.
J.Mol.Biol., 299, 2000
1KNJ
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CO-CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF) FROM E. COLI INVOLVED IN MEVALONATE-INDEPENDENT ISOPRENOID BIOSYNTHESIS, COMPLEXED WITH CMP/MECDP/MN2+
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Richard, S.B., Ferrer, J.L., Bowman, M.E., Lillo, A.M., Tetzlaff, C.N., Cane, D.E., Noel, J.P.
Deposit date:2001-12-18
Release date:2002-06-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
J.Biol.Chem., 277, 2002
1KNK
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CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF) FROM E. COLI INVOLVED IN MEVALONATE-INDEPENDENT ISOPRENOID BIOSYNTHESIS
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION
Authors:Richard, S.B., Ferrer, J.L., Bowman, M.E., Lillo, A.M., Tetzlaff, C.N., Cane, D.E., Noel, J.P.
Deposit date:2001-12-18
Release date:2002-06-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
J.Biol.Chem., 277, 2002
1S2O
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X-RAY STRUCTURE OF THE SUCROSE-PHOSPHATASE (SPP) FROM SYNECHOCYSTIS SP. PCC6803 AT 1.40 A RESOLUTION
Descriptor:sucrose-phosphatase, MAGNESIUM ION
Authors:Fieulaine, S., Lunn, J.E., Borel, F., Ferrer, J.L.
Deposit date:2004-01-09
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
Plant Cell, 17, 2005
1U0M
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CRYSTAL STRUCTURE OF 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE (THNS) FROM STREPTOMYCES COELICOLOR A3(2): A BACTERIAL TYPE III POLYKETIDE SYNTHASE (PKS) PROVIDES INSIGHTS INTO ENZYMATIC CONTROL OF REACTIVE POLYKETIDE INTERMEDIATES
Descriptor:putative polyketide synthase, POLYETHYLENE GLYCOL (N=34), GLYCEROL
Authors:Austin, M.B., Izumikawa, M., Bowman, M.E., Udwary, D.W., Ferrer, J.L., Moore, B.S., Noel, J.P.
Deposit date:2004-07-13
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates
J.Biol.Chem., 279, 2004
1Y6I
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SYNECHOCYSTIS GUN4
Descriptor:Mg-chelatase cofactor GUN4
Authors:Verdecia, M.A., Larkin, R.M., Ferrer, J.L., Riek, R., Chory, J., Noel, J.P.
Deposit date:2004-12-06
Release date:2005-05-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding
Plos Biol., 3, 2005
2BKW
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YEAST ALANINE:GLYOXYLATE AMINOTRANSFERASE YFL030W
Descriptor:ALANINE-GLYOXYLATE AMINOTRANSFERASE 1, PYRIDOXAL-5'-PHOSPHATE, GLYOXYLIC ACID
Authors:Meyer, P., Liger, D., Leulliot, N., Quevillon-Cheruel, S., Zhou, C.Z., Borel, F., Ferrer, J.L., Poupon, A., Janin, J., van Tilbeurgh, H.
Deposit date:2005-02-21
Release date:2005-11-02
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal Structure and Confirmation of the Alanine:Glyoxylate Aminotransferase Activity of the Yfl030W Yeast Protein
Biochimie, 87, 2005
2CDQ
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S- ADENOSYLMETHIONINE
Descriptor:ASPARTOKINASE, LYSINE, D(-)-TARTARIC ACID, ...
Authors:Mas-Droux, C., Curien, G., Robert-Genthon, M., Laurencin, M., Ferrer, J.L., Dumas, R.
Deposit date:2006-01-26
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A Novel Organization of Act Domains in Allosteric Enzymes Revealed by the Crystal Structure of Arabidopsis Aspartate Kinase
Plant Cell, 18, 2006
2F82
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HMG-COA SYNTHASE FROM BRASSICA JUNCEA IN THE APO-FORM
Descriptor:HMG-CoA synthase
Authors:Pojer, F., Ferrer, J.L., Richard, S.B., Noel, J.P.
Deposit date:2005-12-01
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2F9A
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HMG-COA SYNTHASE FROM BRASSICA JUNCEA IN COMPLEX WITH F-244
Descriptor:3-Hydroxy-3-methylglutaryl coenzyme A synthase 1, (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid
Authors:Pojer, F., Ferrer, J.L., Richard, S.B., Noel, J.P.
Deposit date:2005-12-05
Release date:2006-07-25
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FA0
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HMG-COA SYNTHASE FROM BRASSICA JUNCEA IN COMPLEX WITH HMG-COA AND COVALENTLY BOUND TO HMG-COA
Descriptor:HMG-CoA synthase, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A
Authors:Pojer, F., Ferrer, J.L., Richard, S.B., Noel, J.P.
Deposit date:2005-12-06
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FA3
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HMG-COA SYNTHASE FROM BRASSICA JUNCEA IN COMPLEX WITH ACETYL-COA AND ACETYL-CYS117.
Descriptor:HMG-CoA synthase, ACETYL COENZYME *A
Authors:Pojer, F., Ferrer, J.L., Richard, S.B., Noel, J.P.
Deposit date:2005-12-06
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2WHG
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CRYSTAL STRUCTURE OF THE DI-ZINC METALLO-BETA-LACTAMASE VIM-4 FROM PSEUDOMONAS AERUGINOSA
Descriptor:VIM-4 METALLO-BETA-LACTAMASE, ZINC ION, CITRATE ANION
Authors:Lassaux, P., Traore, D.A.K., Galleni, M., Ferrer, J.L.
Deposit date:2009-05-05
Release date:2010-05-19
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Biochemical and Structural Characterization of the Subclass B1 Metallo-{Beta}-Lactamase Vim-4.
Antimicrob.Agents Chemother., 55, 2011
2WHH
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HIV-1 PROTEASE TETHERED DIMER Q-PRODUCT COMPLEX ALONG WITH NUCLEOPHILIC WATER MOLECULE
Descriptor:POL PROTEIN, PARA-NITROPHENYLALANINE, GLUTAMIC ACID
Authors:Prashar, V., Bihani, S., Das, A., Ferrer, J.L., Hosur, M.V.
Deposit date:2009-05-05
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X- Ray Structure Analysis.
Plos One, 4, 2009
3KT2
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CRYSTAL STRUCTURE OF N88D MUTANT HIV-1 PROTEASE
Descriptor:Protease
Authors:Bihani, S.C., Das, A., Prashar, V., Ferrer, J.L., Hosur, M.V.
Deposit date:2009-11-24
Release date:2010-02-16
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
Biochem.Biophys.Res.Commun., 389, 2009
3KT5
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CRYSTAL STRUCTURE OF N88S MUTANT HIV-1 PROTEASE
Descriptor:Protease
Authors:Bihani, S.C., Das, A., Prashar, V., Ferrer, J.L., Hosur, M.V.
Deposit date:2009-11-24
Release date:2010-02-16
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
Biochem.Biophys.Res.Commun., 389, 2009
3ZGL
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CRYSTAL STRUCTURES OF ESCHERICHIA COLI ISPH IN COMPLEX WITH AMBPP A POTENT INHIBITOR OF THE METHYLERYTHRITOL PHOSPHATE PATHWAY
Descriptor:4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, IRON/SULFUR CLUSTER, (2E)-4-amino-3-methylbut-2-en-1-yl trihydrogen diphosphate
Authors:Borel, F., Barbier, E., Kratsutsky, S., Janthawornpong, K., Rohmer, M., Dale Poulter, C., Ferrer, J.L., Seemann, M.
Deposit date:2012-12-18
Release date:2013-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.
Chembiochem, 18, 2017
3ZGN
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CRYSTAL STRUCTURES OF ESCHERICHIA COLI ISPH IN COMPLEX WITH TMBPP A POTENT INHIBITOR OF THE METHYLERYTHRITOL PHOSPHATE PATHWAY
Descriptor:4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, (2E)-3-methyl-4-sulfanylbut-2-en-1-yl trihydrogen diphosphate, IRON/SULFUR CLUSTER
Authors:Borel, F., Barbier, E., Kratsutsky, S., Janthawornpong, K., Rohmer, M., Dale Poulter, C., Ferrer, J.L., Seemann, M.
Deposit date:2012-12-18
Release date:2013-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.
Chembiochem, 18, 2017
4A0F
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STRUCTURE OF SELENOMETHIONINE SUBSTITUTED BIFUNCTIONAL DAPA AMINOTRANSFERASE-DETHIOBIOTIN SYNTHETASE FROM ARABIDOPSIS THALIANA IN ITS APO FORM.
Descriptor:ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION
Authors:Cobessi, D., Dumas, R., Pautre, V., Meinguet, C., Ferrer, J.L., Alban, C.
Deposit date:2011-09-09
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.714 Å)
Cite:Biochemical and Structural Characterization of the Arabidopsis Bifunctional Enzyme Dethiobiotin Synthetase-Diaminopelargonic Acid Aminotransferase: Evidence for Substrate Channeling in Biotin Synthesis.
Plant Cell, 24, 2012
4A0G
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STRUCTURE OF BIFUNCTIONAL DAPA AMINOTRANSFERASE-DTB SYNTHETASE FROM ARABIDOPSIS THALIANA IN ITS APO FORM.
Descriptor:ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, ...
Authors:Cobessi, D., Dumas, R., Pautre, V., Meinguet, C., Ferrer, J.L., Alban, C.
Deposit date:2011-09-09
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Biochemical and Structural Characterization of the Arabidopsis Bifunctional Enzyme Dethiobiotin Synthetase-Diaminopelargonic Acid Aminotransferase: Evidence for Substrate Channeling in Biotin Synthesis.
Plant Cell, 24, 2012