Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4U97
DownloadVisualize
BU of 4u97 by Molmil
Crystal Structure of Asymmetric IRAK4 Dimer
Descriptor: Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
Authors:Ferrao, R, Wu, H.
Deposit date:2014-08-05
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
4U9A
DownloadVisualize
BU of 4u9a by Molmil
Sulphur Anomalous Crystal Structure of Asymmetric IRAK4 Dimer
Descriptor: Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
Authors:Ferrao, R, Liu, Q, Wu, H.
Deposit date:2014-08-05
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
5IXD
DownloadVisualize
BU of 5ixd by Molmil
Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor
Descriptor: CITRIC ACID, Interferon lambda receptor 1, Tyrosine-protein kinase JAK1
Authors:Ferrao, R, Wallweber, H.J.A, Lupardus, P.J.
Deposit date:2016-03-23
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
Structure, 24, 2016
5IXI
DownloadVisualize
BU of 5ixi by Molmil
Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera
Descriptor: Chimera protein of Interferon lambda receptor 1 and Interleukin-10 receptor subunit alpha, Tyrosine-protein kinase JAK1
Authors:Ferrao, R, Wallweber, H.J.A, Lupardus, P.J.
Deposit date:2016-03-23
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
Structure, 24, 2016
6EGE
DownloadVisualize
BU of 6ege by Molmil
Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor
Descriptor: Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide
Authors:Ferrao, R, Liu, Q, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
6EGF
DownloadVisualize
BU of 6egf by Molmil
Crystal structure of the inactive unphosphorylated IRAK4 kinase domain bound to AMP-PNP
Descriptor: Interleukin-1 receptor-associated kinase 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ferrao, R, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
6EGD
DownloadVisualize
BU of 6egd by Molmil
Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor
Descriptor: Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide
Authors:Ferrao, R, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
5V9X
DownloadVisualize
BU of 5v9x by Molmil
Structure of Mycobacterium smegmatis helicase Lhr bound to ssDNA and AMP-PNP
Descriptor: ATP-dependent DNA helicase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Ordonez, H, Jacewicz, A, Ferrao, R, Shuman, S.
Deposit date:2017-03-23
Release date:2017-12-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases.
Nucleic Acids Res., 46, 2018
6E27
DownloadVisualize
BU of 6e27 by Molmil
The CARD9 CARD domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E28
DownloadVisualize
BU of 6e28 by Molmil
The CARD9 CARD domain-swapped dimer
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E2P
DownloadVisualize
BU of 6e2p by Molmil
Structure of human JAK2 FERM/SH2 in complex with Leptin Receptor
Descriptor: Leptin receptor, SULFATE ION, Tyrosine-protein kinase JAK2
Authors:Ferrao, R, Lupardus, P.J, Wallweber, H.J.A.
Deposit date:2018-07-11
Release date:2018-08-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.
Elife, 7, 2018
6E2Q
DownloadVisualize
BU of 6e2q by Molmil
Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor
Descriptor: Erythropoietin receptor, Tyrosine-protein kinase JAK2
Authors:Ferrao, R, Lupardus, P.J.
Deposit date:2018-07-11
Release date:2018-08-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.
Elife, 7, 2018
6BFN
DownloadVisualize
BU of 6bfn by Molmil
Crystal structure of human IRAK1
Descriptor: Interleukin-1 receptor-associated kinase 1, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide
Authors:Wang, L, Qiao, Q, Wu, H.
Deposit date:2017-10-26
Release date:2017-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of human IRAK1.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6E26
DownloadVisualize
BU of 6e26 by Molmil
NMR solution structure of the CARD9 CARD
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6EGA
DownloadVisualize
BU of 6ega by Molmil
IRAK4 in complex with a type II inhibitor
Descriptor: 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ...
Authors:Wang, L, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.512 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
6EG9
DownloadVisualize
BU of 6eg9 by Molmil
IRAK4 in complex with Ponatinib
Descriptor: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ...
Authors:Wang, L, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.414 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
6E25
DownloadVisualize
BU of 6e25 by Molmil
NMR solution structure of the CARD9 CARD bound to zinc
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon