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2Z31
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BU of 2z31 by Molmil
Crystal structure of immune receptor complex
Descriptor: H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain precursor, ...
Authors:Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C.
Deposit date:2007-05-30
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Nat.Immunol., 8, 2007
2Z35
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BU of 2z35 by Molmil
Crystal structure of immune receptor
Descriptor: T-cell receptor alpha-chain, T-cell receptor beta-chain
Authors:Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C.
Deposit date:2007-06-01
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Nat.Immunol., 8, 2007
2PXY
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BU of 2pxy by Molmil
Crystal structures of immune receptor complexes
Descriptor: H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain, ...
Authors:Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C.
Deposit date:2007-05-14
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
Nat.Immunol., 8, 2007
3IJ2
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BU of 3ij2 by Molmil
Ligand-receptor structure
Descriptor: Beta-nerve growth factor, Nerve growth factor receptor (TNFR superfamily, member 16)
Authors:Feng, D, Garcia, K.C.
Deposit date:2009-08-03
Release date:2010-01-12
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Molecular and structural insight into proNGF engagement of p75NTR and sortilin.
J.Mol.Biol., 396, 2010
6O31
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BU of 6o31 by Molmil
CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
Descriptor: Alpha-actinin-4
Authors:Birrane, G, Feng, D.
Deposit date:2019-02-25
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.
J. Am. Soc. Nephrol., 31, 2020
6OA6
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BU of 6oa6 by Molmil
CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
Descriptor: Alpha-actinin-4, GLYCEROL
Authors:Birrane, G, Feng, D.
Deposit date:2019-03-15
Release date:2020-03-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.
J. Am. Soc. Nephrol., 31, 2020
7RBT
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BU of 7rbt by Molmil
cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide
Descriptor: 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S.
Deposit date:2021-07-06
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
6XOX
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BU of 6xox by Molmil
cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970
Descriptor: 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Glucagon-like peptide 1 receptor, ...
Authors:Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S.
Deposit date:2020-07-07
Release date:2020-11-18
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Proc.Natl.Acad.Sci.USA, 117, 2020
5EGM
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BU of 5egm by Molmil
Development of a novel tricyclic class of potent and selective FIXa inhibitors
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-chloranyl-~{N}-[(7~{S})-2-methyl-7-phenyl-10-(1~{H}-1,2,3,4-tetrazol-5-yl)-8,9-dihydro-6~{H}-pyrido[1,2-a]indol-7-yl]-4-(1,2,4-triazol-4-yl)benzamide, Coagulation factor IX, ...
Authors:Meng, D, Andre, P, Bateman, T.J, Berger, R, Chen, Y, Desai, K, Dewnani, S, Ellsworth, K, Feng, D, Geissler, W.M, Guo, L, Hruza, A, Jian, T, Li, H, Parker, D.L, Reichert, P, Sherer, E.C, Smith, C.J, Sonatore, L.M, Tschirret-Guth, R, Wu, J, Xu, J, Zhang, T, Campeau, L, Orr, R, Poirier, M, McCabe-Dunn, j, Araki, K, Nishimura, T, Sakurada, I, Hirabayashi, T, Wood, H.B.
Deposit date:2015-10-27
Release date:2015-11-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
7RG9
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BU of 7rg9 by Molmil
cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S.
Deposit date:2021-07-14
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RA3
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BU of 7ra3 by Molmil
cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP
Descriptor: Gastric inhibitory polypeptide, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S.
Deposit date:2021-06-29
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RGP
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BU of 7rgp by Molmil
cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S.
Deposit date:2021-07-15
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
5VAI
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BU of 5vai by Molmil
Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein
Descriptor: Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G.
Deposit date:2017-03-27
Release date:2017-05-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
5CXV
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BU of 5cxv by Molmil
Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
Descriptor: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, 1,2-ETHANEDIOL, CHOLESTEROL HEMISUCCINATE, ...
Authors:Sun, B, Feng, D, Li, X, Kobilka, T.S, Kobilka, B.K.
Deposit date:2015-07-29
Release date:2016-03-09
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Nature, 531, 2016
6VCB
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BU of 6vcb by Molmil
Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator
Descriptor: 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ...
Authors:Sun, B, Feng, D, Bueno, A, Kobilka, B, Sloop, K.
Deposit date:2019-12-20
Release date:2020-07-22
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.
Nat.Chem.Biol., 16, 2020
6N4X
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BU of 6n4x by Molmil
Metabotropic Glutamate Receptor 5 Apo Form Ligand Binding Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Metabotropic glutamate receptor 5
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Weis, W.I, Skiniotis, G.S, Mathiesen, J.M, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N50
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BU of 6n50 by Molmil
Metabotropic Glutamate Receptor 5 Extracellular Domain in Complex with Nb43 and L-quisqualic acid
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ...
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Chu, M, Weis, W.I, Skiniotis, G, Mathiesen, J.M, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.751 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N4Y
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BU of 6n4y by Molmil
Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ...
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Chu, M, Weis, W.I, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.262 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N52
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BU of 6n52 by Molmil
Metabotropic Glutamate Receptor 5 Apo Form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Weis, W.I, Skiniotis, G.S, Mathiesen, J.M, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N51
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BU of 6n51 by Molmil
Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ...
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Weis, W.I, Skiniotis, G.S, Mathiesen, J.M, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
4GS7
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BU of 4gs7 by Molmil
Structure of the Interleukin-15 quaternary complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ring, A.M, Ozkan, E, Feng, D, Garcia, K.C.
Deposit date:2012-08-27
Release date:2012-11-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Nat.Immunol., 13, 2012
7JOZ
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BU of 7joz by Molmil
Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
Descriptor: 6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, Endolysin,D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Sun, B, Feng, D, Chu, M.L, Fish, I, Kelm, S, Lebon, F, Lovera, S, Valade, A, Wood, M, Ceska, T, Kobilka, T.S, Sands, Z, Kobilka, B.K.
Deposit date:2020-08-07
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist.
Nat Commun, 12, 2021
7MD4
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BU of 7md4 by Molmil
Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists
Descriptor: Insulin B chain, Insulin chain A, Isoform Short of Insulin receptor, ...
Authors:Gomez-Llorente, Y, Zhou, H, Scapin, G.
Deposit date:2021-04-03
Release date:2022-02-23
Last modified:2022-03-02
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Nat Commun, 13, 2022
7MD5
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BU of 7md5 by Molmil
Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gomez-Llorente, Y, Zhou, H, Scapin, G.
Deposit date:2021-04-03
Release date:2022-02-23
Last modified:2022-03-02
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Nat Commun, 13, 2022
7KWU
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BU of 7kwu by Molmil
Crystal Structure of HIV-1 RT in Complex with 16c (K07-15)
Descriptor: 1,2-ETHANEDIOL, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)-5-(pyridin-4-yl)pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzamide, MAGNESIUM ION, ...
Authors:Ruiz, F.X, Arnold, E.
Deposit date:2020-12-02
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.
J.Med.Chem., 64, 2021

 

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