Author results

2PXY
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CRYSTAL STRUCTURES OF IMMUNE RECEPTOR COMPLEXES
Descriptor:T cell receptor alpha chain, T cell receptor beta chain, H-2 class II histocompatibility antigen, ...
Authors:Feng, D., Bond, C.J., Ely, L.K., Garcia, K.C.
Deposit date:2007-05-14
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
Nat.Immunol., 8, 2007
2Z31
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CRYSTAL STRUCTURE OF IMMUNE RECEPTOR COMPLEX
Descriptor:T-cell receptor alpha-chain, T-cell receptor beta-chain, H-2 class II histocompatibility antigen, ...
Authors:Feng, D., Bond, C.J., Ely, L.K., Garcia, K.C.
Deposit date:2007-05-30
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Nat.Immunol., 8, 2007
2Z35
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CRYSTAL STRUCTURE OF IMMUNE RECEPTOR
Descriptor:T-cell receptor alpha-chain, T-cell receptor beta-chain
Authors:Feng, D., Bond, C.J., Ely, L.K., Garcia, K.C.
Deposit date:2007-06-01
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Nat.Immunol., 8, 2007
3IJ2
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LIGAND-RECEPTOR STRUCTURE
Descriptor:Beta-nerve growth factor, Nerve growth factor receptor (TNFR superfamily, member 16)
Authors:Feng, D., Garcia, K.C.
Deposit date:2009-08-03
Release date:2010-01-12
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Molecular and structural insight into proNGF engagement of p75NTR and sortilin.
J.Mol.Biol., 396, 2010
5EGM
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DEVELOPMENT OF A NOVEL TRICYCLIC CLASS OF POTENT AND SELECTIVE FIXA INHIBITORS
Descriptor:Coagulation factor IX, SODIUM ION, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Meng, D., Andre, P., Bateman, T.J., Berger, R., Chen, Y., Desai, K., Dewnani, S., Ellsworth, K., Feng, D., Geissler, W.M., Guo, L., Hruza, A., Jian, T., Li, H., Parker, D.L., Reichert, P., Sherer, E.C., Smith, C.J., Sonatore, L.M., Tschirret-Guth, R., Wu, J., Xu, J., Zhang, T., Campeau, L., Orr, R., Poirier, M., McCabe-Dunn, j., Araki, K., Nishimura, T., Sakurada, I., Hirabayashi, T., Wood, H.B.
Deposit date:2015-10-27
Release date:2015-11-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
4GS7
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STRUCTURE OF THE INTERLEUKIN-15 QUATERNARY COMPLEX
Descriptor:Interleukin-15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, ...
Authors:Ring, A.M., Ozkan, E., Feng, D., Garcia, K.C.
Deposit date:2012-08-27
Release date:2012-11-07
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Nat.Immunol., 13, 2012
5CXV
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STRUCTURE OF THE HUMAN M1 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND TO ANTAGONIST TIOTROPIUM
Descriptor:Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, FLAG peptide, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, ...
Authors:Sun, B., Feng, D., Li, X., Kobilka, T.S., Kobilka, B.K.
Deposit date:2015-07-29
Release date:2016-03-09
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Nature, 531, 2016
5VAI
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CRYO-EM STRUCTURE OF THE ACTIVATED GLUCAGON-LIKE PEPTIDE-1 RECEPTOR IN COMPLEX WITH G PROTEIN
Descriptor:Uncharacterized protein, Glucagon-like peptide 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Zhang, Y., Sun, B., Feng, D., Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Kobilka, T.S., Kobilka, B.K., Skiniotis, G.
Deposit date:2017-03-27
Release date:2017-05-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
6N4X
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METABOTROPIC GLUTAMATE RECEPTOR 5 APO FORM LIGAND BINDING DOMAIN
Descriptor:Metabotropic glutamate receptor 5, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N4Y
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METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN WITH NB43
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.262 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N50
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METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN IN COMPLEX WITH NB43 AND L-QUISQUALIC ACID
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Skiniotis, G., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.751 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N51
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METABOTROPIC GLUTAMATE RECEPTOR 5 BOUND TO L-QUISQUALATE AND NB43
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N52
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METABOTROPIC GLUTAMATE RECEPTOR 5 APO FORM
Descriptor:Metabotropic glutamate receptor 5, N-ACETYL-D-GLUCOSAMINE
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
4PNZ
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH THE LONG-ACTING INHIBITOR OMARIGLIPTIN (MK-3102)
Descriptor:Dipeptidyl peptidase 4, SODIUM ION, (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine, ...
Authors:Scapin, G., Yan, Y.
Deposit date:2014-02-22
Release date:2014-04-09
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes.
J.Med.Chem., 57, 2014
2IIT
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HUMAN DIPEPTIDYL PEPTIDASE 4 IN COMPLEX WITH A DIAZEPAN-2-ONE INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G., Biftu, T., Weber, A.E.
Deposit date:2006-09-28
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem.Lett., 17, 2007
2IIV
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HUMAN DIPEPTIDYL PEPTIDASE 4 IN COMPLEX WITH A DIAZEPAN-2-ONE INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE
Authors:Scapin, G., Weber, A.E., Biftu, T.
Deposit date:2006-09-28
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem.Lett., 17, 2007
2P8S
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH A CYCLOHEXALAMINE INHIBITOR
Descriptor:DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM, N-ACETYL-D-GLUCOSAMINE, SODIUM ION, ...
Authors:Scapin, G., Biftu, T.
Deposit date:2007-03-23
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Bioorg.Med.Chem.Lett., 17, 2007
5DSG
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STRUCTURE OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR (M4-MT4L) BOUND TO TIOTROPIUM
Descriptor:Muscarinic acetylcholine receptor M4,Endolysin,Endolysin,Muscarinic acetylcholine receptor M4, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, OLEIC ACID, ...
Authors:Thal, D.M., Kobilka, B.K., Sexton, P.M., Christopoulos, A.
Deposit date:2015-09-17
Release date:2016-03-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Nature, 531, 2016