Author results

4WRL
  • Download 4wrl
  • View 4wrl
Molmil generated image of 4wrl
STRUCTURE OF THE HUMAN CSF-1:CSF-1R COMPLEX
Descriptor:Macrophage colony-stimulating factor 1 receptor, Macrophage colony-stimulating factor 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Felix, J., De Munck, S., Elegheert, J., Savvides, S.N.
Deposit date:2014-10-24
Release date:2015-08-12
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
4WRM
  • Download 4wrm
  • View 4wrm
Molmil generated image of 4wrm
STRUCTURE OF THE HUMAN CSF-1:CSF-1R COMPLEX
Descriptor:Macrophage colony-stimulating factor 1 receptor, Macrophage colony-stimulating factor 1
Authors:Felix, J., De Munck, S., Elegheert, J., Savvides, S.N.
Deposit date:2014-10-24
Release date:2015-08-12
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (6.853 Å)
Cite:Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
5D22
  • Download 5d22
  • View 5d22
Molmil generated image of 5d22
STRUCTURE OF OVINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Descriptor:Granulocyte-macrophage colony-stimulating factor, ACETATE ION, 1,2-ETHANEDIOL
Authors:Felix, J., Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
5D28
  • Download 5d28
  • View 5d28
Molmil generated image of 5d28
COMPLEX OF GM-CSF/IL-2 INHIBITION FACTOR WITH GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Descriptor:GM-CSF/IL-2 inhibition factor, Granulocyte-macrophage colony-stimulating factor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Felix, J., Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
6HWM
  • Download 6hwm
  • View 6hwm
Molmil generated image of 6hwm
STRUCTURE OF THERMUS THERMOPHILUS CLPP IN COMPLEX WITH BORTEZOMIB
Descriptor:ATP-dependent Clp protease proteolytic subunit, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, DI(HYDROXYETHYL)ETHER
Authors:Felix, J., Schanda, P., Fraga, H., Morlot, C.
Deposit date:2018-10-12
Release date:2019-09-18
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.
Sci Adv, 5, 2019
6HWN
  • Download 6hwn
  • View 6hwn
Molmil generated image of 6hwn
STRUCTURE OF THERMUS THERMOPHILUS CLPP IN COMPLEX WITH A TRIPEPTIDE.
Descriptor:ATP-dependent Clp protease proteolytic subunit, Unknown tripeptide, DI(HYDROXYETHYL)ETHER
Authors:Felix, J., Schanda, P., Fraga, H., Morlot, C.
Deposit date:2018-10-12
Release date:2019-09-18
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.
Sci Adv, 5, 2019
4PU3
  • Download 4pu3
  • View 4pu3
Molmil generated image of 4pu3
SHEWANELLA ONEIDENSIS MR-1 TOXIN ANTITOXIN SYSTEM HIPA, HIPB AND ITS OPERATOR DNA COMPLEX (SPACE GROUP P212121)
Descriptor:Toxin-antitoxin system toxin HipA family, Toxin-antitoxin system antidote transcriptional repressor Xre family, Operator DNA
Authors:Wen, Y., Behiels, E., Felix, J., Elegheert, J., Vergauwen, B., Devreese, B., Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU4
  • Download 4pu4
  • View 4pu4
Molmil generated image of 4pu4
SHEWANELLA ONEIDENSIS MR-1 TOXIN ANTITOXIN SYSTEM HIPA, HIPB AND ITS OPERATOR DNA COMPLEX (SPACE GROUP P21)
Descriptor:Toxin-antitoxin system toxin HipA family, Toxin-antitoxin system antidote transcriptional repressor Xre family, Operator DNA
Authors:Wen, Y., Behiels, E., Felix, J., Elegheert, J., Vergauwen, B., Devreese, B., Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (3.786 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU5
  • Download 4pu5
  • View 4pu5
Molmil generated image of 4pu5
SHEWANELLA ONEIDENSIS TOXIN ANTITOXIN SYSTEM TOXIN PROTEIN HIPA BOUND WITH AMPPNP AND MG
Descriptor:Toxin-antitoxin system toxin HipA family, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Wen, Y., Behiels, E., Felix, J., Elegheert, J., Vergauwen, B., Devreese, B., Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.834 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU7
  • Download 4pu7
  • View 4pu7
Molmil generated image of 4pu7
SHEWANELLA ONEIDENSIS TOXIN ANTITOXIN SYSTEM ANTITOXIN PROTEIN HIPB RESOLUTION 1.85
Descriptor:Toxin-antitoxin system antidote transcriptional repressor Xre family
Authors:Wen, Y., Behiels, E., Felix, J., Elegheert, J., Vergauwen, B., Devreese, B., Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU8
  • Download 4pu8
  • View 4pu8
Molmil generated image of 4pu8
SHEWANELLA ONEIDENSIS TOXIN ANTITOXIN SYSTEM ANTITOXIN PROTEIN HIPB RESOLUTION 2.35
Descriptor:Toxin-antitoxin system antidote transcriptional repressor Xre family
Authors:Wen, Y., Behiels, E., Felix, J., Elegheert, J., Vergauwen, B., Devreese, B., Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
6JJJ
  • Download 6jjj
  • View 6jjj
Molmil generated image of 6jjj
TRIMERIC STRUCTURE OF KUPFFER CELL C-TYPE LECTIN RECEPTOR CLEC4F
Descriptor:C-type lectin domain family 4 member F, CALCIUM ION
Authors:Wen, Y., Ouyang, Z., Felix, J.
Deposit date:2019-02-26
Release date:2019-08-14
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.
Febs Lett., 594, 2020
6Q7L
  • Download 6q7l
  • View 6q7l
Molmil generated image of 6q7l
SPIRAL STRUCTURE OF E. COLI RAVA IN THE RAVA-LDCI CAGE-LIKE COMPLEX
Descriptor:Inducible lysine decarboxylase, ATPase RavA, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Arragain, B., Felix, J., Malet, H., Gutsche, I., Jessop, M.
Deposit date:2018-12-13
Release date:2020-02-12
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.
Commun Biol, 3, 2020
6Q7M
  • Download 6q7m
  • View 6q7m
Molmil generated image of 6q7m
SPIRAL STRUCTURE OF E. COLI RAVA IN THE RAVA-LDCI CAGE-LIKE COMPLEX
Descriptor:Inducible lysine decarboxylase, ATPase RavA, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Arragain, B., Felix, J., Malet, H., Gutsche, I., Jessop, M.
Deposit date:2018-12-13
Release date:2020-02-12
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.
Commun Biol, 3, 2020
6SZA
  • Download 6sza
  • View 6sza
Molmil generated image of 6sza
MOXR AAA-ATPASE RAVA, C2-SYMMETRIC CLOSED RING CONFORMATION
Descriptor:RavA, ADENOSINE-5'-DIPHOSPHATE
Authors:Jessop, M., Felix, J., Gutsche, I.
Deposit date:2019-10-02
Release date:2020-02-19
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.
Commun Biol, 3, 2020
6SZB
  • Download 6szb
  • View 6szb
Molmil generated image of 6szb
MOXR AAA-ATPASE RAVA, SPIRAL OPEN RING CONFORMATION
Descriptor:RavA + Mg-ADP, ADENOSINE-5'-DIPHOSPHATE
Authors:Jessop, M., Felix, J., Gutsche, I.
Deposit date:2019-10-02
Release date:2020-02-19
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.
Commun Biol, 3, 2020
6MK0
  • Download 6mk0
  • View 6mk0
Molmil generated image of 6mk0
INTEGRIN ALPHAVBETA3 ECTODOMAIN BOUND TO ANTAGONIST TDI-4161
Descriptor:Integrin alpha-V, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:van Agthoven, J., Arnaout, M.A.
Deposit date:2018-09-24
Release date:2019-09-25
Last modified:2020-02-12
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019
6HXH
  • Download 6hxh
  • View 6hxh
Molmil generated image of 6hxh
STRUCTURE OF THE HUMAN ATP CITRATE LYASE HOLOENZYME IN COMPLEX WITH CITRATE, COENZYME A AND MG.ADP
Descriptor:ATP-citrate synthase,Human ATP citrate lyase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXI
  • Download 6hxi
  • View 6hxi
Molmil generated image of 6hxi
STRUCTURE OF ATP CITRATE LYASE FROM METHANOTHRIX SOEHNGENII IN COMPLEX WITH CITRATE AND COENZYME A
Descriptor:Citrate lyase, subunit 1, Succinyl-CoA ligase (ADP-forming) subunit alpha, ...
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXJ
  • Download 6hxj
  • View 6hxj
Molmil generated image of 6hxj
STRUCTURE OF ATP CITRATE LYASE FROM CHLOROBIUM LIMICOLA IN COMPLEX WITH CITRATE AND COENZYME A.
Descriptor:ATP-citrate lyase beta-subunit, ATP-citrate lyase alpha-subunit, CITRATE ANION, ...
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXK
  • Download 6hxk
  • View 6hxk
Molmil generated image of 6hxk
STRUCTURE OF THE CITRYL-COA LYASE CORE MODULE OF HUMAN ATP CITRATE LYASE IN COMPLEX WITH CITRATE
Descriptor:ATP-citrate synthase, CITRATE ANION, 1,2-ETHANEDIOL, ...
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXL
  • Download 6hxl
  • View 6hxl
Molmil generated image of 6hxl
STRUCTURE OF THE CITRYL-COA LYASE CORE MODULE OF HUMAN ATP CITRATE LYASE IN COMPLEX WITH CITRATE AND COASH (SPACE GROUP P21)
Descriptor:ATP-citrate synthase, COENZYME A, CITRATE ANION, ...
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXM
  • Download 6hxm
  • View 6hxm
Molmil generated image of 6hxm
STRUCTURE OF THE CITRYL-COA LYASE CORE MODULE OF HUMAN ATP CITRATE LYASE IN COMPLEX WITH CITRATE AND COASH IN SPACE GROUP C2221
Descriptor:ATP-citrate synthase, COENZYME A, CITRATE ANION
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXN
  • Download 6hxn
  • View 6hxn
Molmil generated image of 6hxn
STRUCTURE OF THE CITRYL-COA LYASE CORE MODULE OF CHLOROBIUM LIMICOLA ATP CITRATE LYASE (SPACE GROUP P3121)
Descriptor:ATP-citrate lyase alpha-subunit, COENZYME A, SULFATE ION
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXO
  • Download 6hxo
  • View 6hxo
Molmil generated image of 6hxo
STRUCTURE OF THE CITRYL-COA LYASE CORE MODULE OF CHLOROBIUM LIMICOLA ATP CITRATE LYASE (SPACE GROUP P21)
Descriptor:ATP-citrate lyase alpha-subunit, CITRATE ANION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Verstraete, K., Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
<12>