Author results

5OCH
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THE CRYSTAL STRUCTURE OF HUMAN ABCB8 IN AN OUTWARD-FACING STATE
Descriptor:ATP-binding cassette sub-family B member 8, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Faust, B., Pike, A.C.W., Shintre, C.A., Quiqley, A.M., Chu, A., Barr, A., Shrestha, L., Mukhopadhyay, S., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of human ABCB8 in an outward-facing state
To Be Published
6O3C
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CRYSTAL STRUCTURE OF ACTIVE SMOOTHENED BOUND TO SAG21K, CHOLESTEROL, AND NBSMO8
Descriptor:Smoothened homolog, NbSmo8, PHOSPHATE ION, ...
Authors:Deshpande, I.S., Liang, J., Hedeen, D., Roberts, K.J., Zhang, Y., Ha, B., Latorraca, N.R., Faust, B., Dror, R.O., Beachy, P.A., Myers, B.R., Manglik, A.
Deposit date:2019-02-26
Release date:2019-07-03
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Nature, 571, 2019
4LLH
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SUBSTRATE BOUND OUTWARD-OPEN STATE OF THE SYMPORTER BETP
Descriptor:Glycine betaine transporter BetP, 2-(trimethyl-lambda~5~-arsanyl)ethanol, SODIUM ION, ...
Authors:Perez, C., Faust, B., Ziegler, C.
Deposit date:2013-07-09
Release date:2014-05-07
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na(+) coupling.
Nat Commun, 5, 2014
4TWK
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK1 (K2P2.1)
Descriptor:Potassium channel subfamily K member 2, POTASSIUM ION, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P.
Deposit date:2014-06-30
Release date:2014-08-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
To Be Published
4CXA
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CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLIN K COMPLEX BOUND TO AMPPNP
Descriptor:CYCLIN-DEPENDENT KINASE 12, CYCLIN-K, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Nowak, R., Goubin, S., Mahajan, R.P., Kopec, J., Froese, S., Tallant, C., Carpenter, E.P., Mackenzie, A., Faust, B., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-04-04
Release date:2014-05-21
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding.
Sci.Rep., 5, 2015
5A6R
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN KCTD17
Descriptor:BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD17
Authors:Pinkas, D.M., Sorrell, F., Sanvitale, C.E., Goubin, S., Williams, E., Newman, J.A., Pearce, N.M., Neshich, I., Pike, A.C.W., MacKenzie, A., Quigley, A., Faust, B., Carpenter, E.P., Tallant, C., Kopec, J., Chalk, R., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
5MP0
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HUMAN M7GPPPN-MRNA HYDROLASE (DCP2, NUDT20) CATALYTIC DOMAIN
Descriptor:m7GpppN-mRNA hydrolase, 1,2-ETHANEDIOL
Authors:Mathea, S., Salah, E., Velupillai, S., Tallant, C., Pike, A.C.W., Bushell, S.R., Faust, B., Wang, D., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Huber, K.
Deposit date:2016-12-15
Release date:2017-06-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic Domain
To Be Published