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1GBR
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ORIENTATION OF PEPTIDE FRAGMENTS FROM SOS PROTEINS BOUND TO THE N-TERMINAL SH3 DOMAIN OF GRB2 DETERMINED BY NMR SPECTROSCOPY
Descriptor:GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, SOS-A PEPTIDE
Authors:Wittekind, M., Mapelli, C., Farmer, B.T., Suen, K.-L., Goldfarb, V., Tsao, J., Lavoie, T., Barbacid, M., Meyers, C.A., Mueller, L.
Deposit date:1994-08-12
Release date:1995-01-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy.
Biochemistry, 33, 1994
3F2A
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CRYSTAL STRUCTURE OF HUMAN PIM-1 IN COMPLEX WITH DAPPA
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION
Authors:Qian, K.
Deposit date:2008-10-29
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.
J.Med.Chem., 52, 2009
3I7G
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MMP-13 IN COMPLEX WITH A NON ZINC-CHELATING INHIBITOR
Descriptor:Collagenase 3, ZINC ION, CALCIUM ION, ...
Authors:Farrow, N.A.
Deposit date:2009-07-08
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3I7I
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MMP-13 IN COMPLEX WITH A NON ZINC-CHELATING INHIBITOR
Descriptor:Collagenase 3, ZINC ION, CALCIUM ION, ...
Authors:Farrow, N.A., Margarit, S.M.
Deposit date:2009-07-08
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.208 Å)
Cite:Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009