Author results

1FD7
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HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH BOUND LIGAND BMSC001
Descriptor:HEAT-LABILE ENTEROTOXIN B CHAIN, N-BENZYL-3-(ALPHA-D-GALACTOS-1-YL)-BENZAMIDE
Authors:Fan, E., Merritt, E.A., Pickens, J., Ahn, M., Hol, W.G.J.
Deposit date:2000-07-19
Release date:2000-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
4GFT
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MALARIA INVASION MACHINERY PROTEIN-NANOBODY COMPLEX
Descriptor:Myosin A tail domain interacting protein, Nanobody, 1,2-ETHANEDIOL
Authors:Khamrui, S., Turley, S., Pardon, E., Steyaert, J., Verlinde, C., Fan, E., Bergman, L.W., Hol, W.G.J.
Deposit date:2012-08-03
Release date:2013-07-03
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.
Mol.Biochem.Parasitol., 190, 2013
1Z1D
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STRUCTURAL MODEL FOR THE INTERACTION BETWEEN RPA32 C-TERMINAL DOMAIN AND SV40 T ANTIGEN ORIGIN BINDING DOMAIN.
Descriptor:Replication protein A 32 kDa subunit, Large T antigen
Authors:Arunkumar, A.I., Klimovich, V., Jiang, X., Ott, R.D., Mizoue, L., Fanning, E., Chazin, W.J.
Deposit date:2005-03-03
Release date:2005-05-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome.
Nat.Struct.Mol.Biol., 12, 2005
1DJR
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH M-CARBOXYPHENYL-ALPHA-D-GALACTOSE
Descriptor:HEAT-LABILE ENTEROTOXIN, ALPHA D-GALACTOSE, GLYCEROL, ...
Authors:Minke, W.E., Pickens, J., Merritt, E.A., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:1999-12-03
Release date:2000-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes.
Acta Crystallogr.,Sect.D, 56, 2000
1MD2
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CHOLERA TOXIN B-PENTAMER WITH DECAVALENT LIGAND BMSC-0013
Descriptor:CHOLERA TOXIN B SUBUNIT, [5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLCARBAMOYL)-PENTYL]-CARBAMIC ACID METHYL ESTER, 3-ETHYLAMINO-4-METHYLAMINO-CYCLOBUTANE-1,2-DIONE, ...
Authors:Zhang, Z., Merritt, E.A., Ahn, M., Roach, C., Hol, W.G.J., Fan, E.
Deposit date:2002-08-06
Release date:2002-12-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.
J.Am.Chem.Soc., 124, 2002
1N25
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CRYSTAL STRUCTURE OF THE SV40 LARGE T ANTIGEN HELICASE DOMAIN
Descriptor:Large T Antigen, ZINC ION
Authors:Li, D., Zhao, R., Lilyestrom, W., Gai, D., Zhang, R., DeCaprio, J.A., Fanning, E., Jochimiak, A., Szakonyi, G., Chen, X.S.
Deposit date:2002-10-21
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen
Nature, 423, 2003
1PZI
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH NITROPHENYL GALACTOSIDE 2A
Descriptor:Heat-labile Enterotoxin B subunit, N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE
Authors:Mitchell, D.D., Pickens, J.C., Korotkov, K., Fan, E., Hol, W.G.J.
Deposit date:2003-07-11
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies
Bioorg.Med.Chem., 12, 2004
1PZJ
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH NITROPHENYL GALACTOSIDE 5
Descriptor:Cholera Toxin B Subunit, N-{3-[4-(3-AMINO-PROPYL)-PIPERAZIN-1-YL]-PROPYL}-3-NITRO-5-(GALACTOPYRANOSYL)-BETA-BENZAMIDE, N-{3-[4-(3-AMINO-PROPYL)-PIPERAZIN-1-YL]-PROPYL}-3-NITRO-5-(GALACTOPYRANOSYL)-ALPHA-BENZAMIDE
Authors:Mitchell, D.D., Pickens, J.C., Korotkov, K., Fan, E., Hol, W.G.J.
Deposit date:2003-07-11
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies
Bioorg.Med.Chem., 12, 2004
1PZK
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH N-ACYL PHENYL GALACTOSIDE 9H
Descriptor:Cholera Toxin B Subunit, N-{3-[4-(3-AMINO-PROPYL)-PIPERAZIN-1-YL]-PROPYL}-3-(2-THIOPHEN-2-YL-ACETYLAMINO)-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE
Authors:Mitchell, D.D., Pickens, J.C., Korotkov, K., Fan, E., Hol, W.G.J.
Deposit date:2003-07-11
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies
Bioorg.Med.Chem., 12, 2004
1RCV
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH BIVALENT NITROPHENOL-GALACTOSIDE LIGAND BV1
Descriptor:cholera toxin B protein (CTB), [3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO] -2-(3-{4-[3-(3-NITRO-5-[GALACTOPYRANOSYLOXY]-BENZOYLAMINO)-PROPYL]-PIPERAZIN-1-YL} -PROPYL-AMINO)-3,4-DIOXO-CYCLOBUTENE
Authors:Pickens, J.C., Mitchell, D.D., Liu, J., Tan, X., Zhang, Z., Verlinde, C.L., Hol, W.G., Fan, E.
Deposit date:2003-11-04
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chem.Biol., 11, 2004
1RD9
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH BIVALENT NITROPHENOL-GALACTOSIDE LIGAND BV2
Descriptor:cholera toxin B protein (CTB), 1,3-BIS-([3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYL-AMINO]-CARBONYLOXY)-2-AMINO-PROPANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Pickens, J.C., Mitchell, D.D., Liu, J., Tan, X., Zhang, Z., Verlinde, C.L., Hol, W.G., Fan, E.
Deposit date:2003-11-05
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chem.Biol., 11, 2004
1RDP
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH BIVALENT NITROPHENOL-GALACTOSIDE LIGAND BV3
Descriptor:cholera toxin B protein (CTB), 1,3-BIS-([[3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO-3,4-DIOXO-CYCLOBUTENYL]-AMINO-ETHYL]-AMINO-CARBONYLOXY)-2-AMINO-PROPANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Pickens, J.C., Mitchell, D.D., Liu, J., Tan, X., Zhang, Z., Verlinde, C.L., Hol, W.G., Fan, E.
Deposit date:2003-11-05
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chem.Biol., 11, 2004
1RF2
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH BIVALENT NITROPHENOL-GALACTOSIDE LIGAND BV4
Descriptor:cholera toxin B protein (CTB), 1,3-BIS-([3-[3-[3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO-3,4-DIOXO-CYCLOBUTENYL]-AMINO-PROPOXY-ETHOXY-ETHOXY]-PROPYL-]AMINO-CARBONYLOXY)-2-AMINO-PROPANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Pickens, J.C., Mitchell, D.D., Liu, J., Tan, X., Zhang, Z., Verlinde, C.L., Hol, W.G., Fan, E.
Deposit date:2003-11-07
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chem.Biol., 11, 2004
2KEB
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NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE DNA POLYMERASE ALPHA P68 SUBUNIT
Descriptor:DNA polymerase subunit alpha B
Authors:Huang, H., Weiner, B.E., Zhang, H., Fuller, B.E., Gao, Y., Wile, B.M., Chazin, W.J., Fanning, E.
Deposit date:2009-01-28
Release date:2010-02-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome.
J.Biol.Chem., 285, 2010
4E2I
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THE COMPLEX STRUCTURE OF THE SV40 HELICASE LARGE T ANTIGEN AND P68 SUBUNIT OF DNA POLYMERASE ALPHA-PRIMASE
Descriptor:Large T antigen, DNA polymerase alpha subunit B, ZINC ION
Authors:Zhou, B., Arnett, D.R., Yu, X., Brewster, A., Sowd, G.A., Xie, C.L., Vila, S., Gai, D., Fanning, E., Chen, X.S.
Deposit date:2012-03-08
Release date:2012-06-13
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (5 Å)
Cite:Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase alpha-primase.
J.Biol.Chem., 287, 2012
4EG1
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH SUBSTRATE METHIONINE
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG3
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH PRODUCT METHIONYL-ADENYLATE
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG4
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH INHIBITOR CHEM 1289
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.151 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG5
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH INHIBITOR CHEM 1312
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG6
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH INHIBITOR CHEM 1325
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG7
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH INHIBITOR CHEM 1331
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.747 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG8
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH COMPOUND CHEM 89
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EGA
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH INHIBITOR CHEM 1320
Descriptor:Methionyl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Koh, C.Y., Kim, J.E., Shibata, S., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4MVW
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH INHIBITOR 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA (CHEM 1433)
Descriptor:Methionyl-tRNA synthetase, GLYCEROL, DIMETHYL SULFOXIDE, ...
Authors:Koh, C.Y., Kim, J.E., Wetzel, A.B., de van der Schueren, W.J., Shibata, S., Liu, J., Zhang, Z., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2013-09-24
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014
4MVX
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TRYPANOSOMA BRUCEI METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH INHIBITOR 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-PHENYLUREA (CHEM 1356)
Descriptor:Methionyl-tRNA synthetase, GLYCEROL, DIMETHYL SULFOXIDE, ...
Authors:Koh, C.Y., Kim, J.E., Wetzel, A.B., de van der Schueren, W.J., Shibata, S., Liu, J., Zhang, Z., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:2013-09-24
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014