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4DIK
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FLAVO DI-IRON PROTEIN H90A MUTANT FROM THERMOTOGA MARITIMA
分子名称:FLAVOPROTEIN, CHLORIDE ION, MU-OXO-DIIRON
著者Fang, H., Caranto, J.D., Taylor, A.B., Hart, P.J., Kurtz Jr., D.M.
登録日2012-01-31
公開日2012-10-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Histidine ligand variants of a flavo-diiron protein: effects on structure and activities.
J.Biol.Inorg.Chem., 17, 2012
4DIL
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FLAVO DI-IRON PROTEIN H90N MUTANT FROM THERMOTOGA MARITIMA
分子名称:FLAVOPROTEIN, CHLORIDE ION, MU-OXO-DIIRON
著者Fang, H., Caranto, J.D., Taylor, A.B., Hart, P.J., Kurtz, D.M.
登録日2012-01-31
公開日2012-10-17
最終更新日2014-10-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Histidine ligand variants of a flavo-diiron protein: effects on structure and activities.
J.Biol.Inorg.Chem., 17, 2012
5ZGE
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CRYSTAL STRUCTURE OF NDM-1 AT PH5.5 (BIS-TRIS) IN COMPLEX WITH HYDROLYZED AMPICILLIN
分子名称:Metallo-beta-lactamase type 2, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-08
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGF
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CRYSTAL STRUCTURE OF NDM-1 Q123G MUTANT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION
著者Zhang, H., Hao, Q.
登録日2018-03-08
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGI
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CRYSTAL STRUCTURE OF NDM-1 AT PH6.5 (SUCCINATE) WITH 1 MOLECULE PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-09
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGP
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CRYSTAL STRUCTURE OF NDM-1 AT PH6.2 (BIS-TRIS) IN COMPLEX WITH HYDROLYZED AMPICILLIN
分子名称:Metallo-beta-lactamase type 2, ZINC ION, DI(HYDROXYETHYL)ETHER, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGQ
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.5 (TRIS-HCL, (NH4)2SO4) IN COMPLEX WITH HYDROLYZED AMPICILLIN
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGR
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.3 (HEPES) IN COMPLEX WITH HYDROLYZED AMPICILLIN
分子名称:Metallo-beta-lactamase type 2, ZINC ION, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGT
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.5 (HEPES) WITH 2 MOLECULES PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGU
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.0 (HEPES) WITH 2 MOLECULES PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGV
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CRYSTAL STRUCTURE OF NDM-1 AT PH8.0 (TRIS) WITH 2 MOLECULES PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGW
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.5 WITH 1 MOLECULE PER ASYMMETRIC UNIT (CRYSTALLIZED AT SUCCINATE PH5.5 AND SOAKED AT SUCCINATE PH7.5)
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGX
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.5 (SUCCINATE) WITH 1 MOLECULE PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, 1,2-ETHANEDIOL, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGY
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.5 (BIS-TRIS) WITH 1 MOLECULE PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGZ
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.5 (IMIDAZOLE) WITH 1 MOLECULE PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZH1
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CRYSTAL STRUCTURE OF NDM-1 AT PH7.5 (IMIDAZOLE) WITH 2 MOLECULES PER ASYMMETRIC UNIT
分子名称:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
著者Zhang, H., Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
2AI6
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SOLUTION STRUCTURE OF HUMAN PHOSPHOHISTIDINE PHOSPHATASE 1
分子名称:14 kDa phosphohistidine phosphatase
著者Gong, W., Cui, G., Jin, C., Xia, B.
登録日2005-07-29
公開日2006-10-17
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and catalytic mechanism of human protein histidine phosphatase 1.
Biochem.J., 418, 2009
2OZX
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SOLUTION STRUCTURE OF HUMAN PHOSPHOHISTIDINE PHOSPHATASE 1 IN PHOSPHATE FREE FORM
分子名称:14 kDa phosphohistidine phosphatase
著者Gong, W., Cui, G., Jin, C., Xia, B.
登録日2007-02-27
公開日2008-03-25
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and catalytic mechanism of human protein histidine phosphatase 1.
Biochem.J., 418, 2009
5GP4
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LACTOBACILLUS BREVIS CGMCC 1306 GLUTAMATE DECARBOXYLASE
分子名称:Glutamate decarboxylase, PYRIDOXAL-5'-PHOSPHATE
著者Mei, L., Huang, J.
登録日2016-07-31
公開日2017-08-02
最終更新日2018-09-12
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Lactobacillus brevis CGMCC 1306 glutamate decarboxylase: Crystal structure and functional analysis.
Biochem. Biophys. Res. Commun., 503, 2018
5QJ0
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ETHYL(METHYLSULFONYL)AMINO]-2-(4-FLUOROPHENYL)-N-METHYL-5-(3-{[1-(PYRIMIDIN-2-YL)CYCLOPROPYL]CARBAMOYL}PHENYL)-1-BENZOFURAN-3-CARBOXAMIDE
分子名称:RNA-dependent RNA polymerase, 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, THIOCYANATE ION, ...
著者Sheriff, S.
登録日2018-08-13
公開日2018-11-21
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
ACS Med Chem Lett, 9, 2018
5QJ1
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-5-(3-{[1-(5-FLUOROPYRIMIDIN-2-YL)CYCLOPROPYL]CARBAMOYL}-4-METHOXYPHENYL)-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE
分子名称:RNA-dependent RNA polymerase, 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide, SULFATE ION, ...
著者Sheriff, S.
登録日2018-08-13
公開日2018-11-21
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
ACS Med Chem Lett, 9, 2018
5TWM
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-N-METHYLFURO[2,3-B]PYRIDINE-3-CARBOXAMIDE
分子名称:NS5B RNA-dependent RNA POLYMERASE, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, SULFATE ION, ...
著者Sheriff, S.
登録日2016-11-14
公開日2017-03-15
最終更新日2018-10-31
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm, 8, 2017
5TWN
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-N-METHYLFURO[2,3-B]PYRIDINE-3-CARBOXAMIDE
分子名称:NS5B RNA- DEPENDENT RNA POLYMERASE, (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, SULFATE ION, ...
著者Sheriff, S.
登録日2016-11-14
公開日2017-03-15
最終更新日2018-10-31
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm, 8, 2017