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5I0K
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BU of 5i0k by Molmil
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases
Descriptor: CROTONYL COENZYME A, Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2016-02-04
Release date:2017-08-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
5L84
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BU of 5l84 by Molmil
Structure of the H959F variant of the PpsC dehydratase domain from Mycobacterium tuberculosis
Descriptor: Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A, Gavalda, S, Mourey, L, Pedelacq, J.D.
Deposit date:2016-06-07
Release date:2017-08-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
4U89
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BU of 4u89 by Molmil
4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
Descriptor: COENZYME A, IMIDAZOLE, PHOSPHATE ION, ...
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2014-08-01
Release date:2015-08-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:X-ray structure of the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
to be published
8A3D
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BU of 8a3d by Molmil
Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 28S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Faille, A, Warren, A.J, Dent, K.C.
Deposit date:2022-06-08
Release date:2023-03-08
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (1.67 Å)
Cite:The chemical landscape of the human ribosome at 1.67 angstrom resolution.
Biorxiv, 2023
7OW7
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BU of 7ow7 by Molmil
EIF6-bound large subunit of the human ribosome
Descriptor: 28S rRNA, 5.8S ribosomal RNA, 5S rRNA, ...
Authors:Faille, A, Warren, A.J.
Deposit date:2021-06-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structure of human EIF6-bound large ribosomal subunit
To Be Published
4OOC
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BU of 4ooc by Molmil
Dehydratase domain of the polyketide PpsC from Mycobacterium tuberculosis
Descriptor: PHOSPHATE ION, Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2014-01-31
Release date:2015-08-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
4OKI
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BU of 4oki by Molmil
X-ray structure of the nucleotide-binding subdomain of the enoylreductase domain of PpsC from Mycobacterium tuberculosis
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Phthiocerol synthesis polyketide synthase type I PpsC, SODIUM ION
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2014-01-22
Release date:2015-08-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
6EZO
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BU of 6ezo by Molmil
Eukaryotic initiation factor EIF2B in complex with ISRIB
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Human eukaryotic initiation factor EIF2B epsilon subunits, Translation initiation factor eIF-2B subunit alpha, ...
Authors:Faille, A, Weis, F, Zyryanova, A, Warren, A.J, Ron, D.
Deposit date:2017-11-16
Release date:2018-03-28
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Science, 359, 2018
5NJI
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BU of 5nji by Molmil
Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA
Descriptor: Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate
Authors:Gavalda, S, Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2017-03-28
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
7AHB
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BU of 7ahb by Molmil
Acyltransferase domain of the polyketide synthase PpsC of Mycobacterium tuberculosis
Descriptor: GLYCEROL, Phthiocerol synthesis polyketide synthase type I PpsC, SODIUM ION, ...
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2020-09-24
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
6QIK
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BU of 6qik by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-01-20
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6QT0
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BU of 6qt0 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-02-22
Release date:2019-06-26
Last modified:2019-10-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6QTZ
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BU of 6qtz by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-02-26
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6S05
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BU of 6s05 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6RI5
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BU of 6ri5 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S RNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-04-23
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6RZZ
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BU of 6rzz by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
7AGR
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BU of 7agr by Molmil
Structure of the M624V-S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis soaked with MethylMalonyl Coenzyme A
Descriptor: 1,2-ETHANEDIOL, Mycocerosic acid synthase
Authors:Brison, Y, Mourey, L, Maveyraud, L.
Deposit date:2020-09-23
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
7AGS
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BU of 7ags by Molmil
Structure of the AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis acylated MethylMalonyl-CoenzymeA
Descriptor: METHYLMALONIC ACID, Mycocerosic acid synthase
Authors:Brison, Y, Mourey, L, Maveyraud, L.
Deposit date:2020-09-23
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
7AGP
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BU of 7agp by Molmil
Structure of the AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis
Descriptor: 1,2-ETHANEDIOL, Mycocerosic acid synthase
Authors:Brison, Y, Nahoum, V, Mourey, L, Maveyraud, L.
Deposit date:2020-09-23
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
7AGQ
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BU of 7agq by Molmil
Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis
Descriptor: ACETATE ION, GLYCEROL, Mycocerosic acid synthase
Authors:Brison, Y, Mourey, L, Maveyraud, L.
Deposit date:2020-09-23
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
7AKC
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BU of 7akc by Molmil
Structure of the of AcylTransferase domain of phenolphthiocerol/phtiocerol synthase A from Mycobacterium bovis (BCG)
Descriptor: Phenolpthiocerol synthesis type-I polyketide synthase ppsA, SODIUM ION
Authors:Brison, Y, Nahoum, V, Mourey, L, Maveyraud, L.
Deposit date:2020-09-30
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
7AGT
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BU of 7agt by Molmil
Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis acylated with Malonyl-coenzyme A
Descriptor: MALONIC ACID, Mycocerosic acid synthase
Authors:Brison, Y, Mourey, L, Maveyraud, L.
Deposit date:2020-09-23
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
7AGU
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BU of 7agu by Molmil
Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis acylated with MethylMalonyl-coenzyme A
Descriptor: 1,2-ETHANEDIOL, METHYLMALONIC ACID, Mycocerosic acid synthase
Authors:Brison, Y, Mourey, L, Maveyraud, L.
Deposit date:2020-09-23
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020

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