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4OKI
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X-RAY STRUCTURE OF THE NUCLEOTIDE-BINDING SUBDOMAIN OF THE ENOYLREDUCTASE DOMAIN OF PPSC FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Phthiocerol synthesis polyketide synthase type I PpsC, SODIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Faille, A., Mourey, L., Pedelacq, J.D.
Deposit date:2014-01-22
Release date:2015-08-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
4OOC
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DEHYDRATASE DOMAIN OF THE POLYKETIDE PPSC FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Phthiocerol synthesis polyketide synthase type I PpsC, PHOSPHATE ION
Authors:Faille, A., Mourey, L., Pedelacq, J.D.
Deposit date:2014-01-31
Release date:2015-08-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
5I0K
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INSIGHTS INTO SUBSTRATE MODIFICATION BY DEHYDRATASES FROM TYPE I POLYKETIDE SYNTHASES
Descriptor:Phthiocerol synthesis polyketide synthase type I PpsC, CROTONYL COENZYME A
Authors:Faille, A., Mourey, L., Pedelacq, J.D.
Deposit date:2016-02-04
Release date:2017-08-09
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
5L84
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STRUCTURE OF THE H959F VARIANT OF THE PPSC DEHYDRATASE DOMAIN FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A., Gavalda, S., Mourey, L., Pedelacq, J.D.
Deposit date:2016-06-07
Release date:2017-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
4U89
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4'-PHOSPHOPANTETHEINYL TRANSFERASE PPTT FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Phosphopantetheinyl transferase PptT, COENZYME A, SODIUM ION, ...
Authors:Faille, A., Mourey, L., Pedelacq, J.D.
Deposit date:2014-08-01
Release date:2015-08-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:X-ray structure of the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
to be published
5NJI
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STRUCTURE OF THE DEHYDRATASE DOMAIN OF PPSC FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH C12:1-COA
Descriptor:Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate
Authors:Gavalda, S., Faille, A., Mourey, L., Pedelacq, J.D.
Deposit date:2017-03-28
Release date:2017-05-31
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
6EZO
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EUKARYOTIC INITIATION FACTOR EIF2B IN COMPLEX WITH ISRIB
Descriptor:Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ...
Authors:Faille, A., Weis, F., Zyryanova, A., Warren, A.J., Ron, D.
Deposit date:2017-11-16
Release date:2018-03-28
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Science, 359, 2018