8TAH
| Cryo-EM structure of Cortactin-bound to Arp2/3 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ... | Authors: | Fregoso, F.E, van Eeuwen, T, Dominguez, R. | Deposit date: | 2023-06-27 | Release date: | 2023-09-27 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins. Nat Commun, 14, 2023
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1CR9
| CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 | Descriptor: | FAB ANTIBODY HEAVY CHAIN, FAB ANTIBODY LIGHT CHAIN | Authors: | Kanyo, Z.F, Pan, K.M, Williamson, R.A, Burton, D.R, Prusiner, S.B, Fletterick, R.J, Cohen, F.E. | Deposit date: | 1999-08-14 | Release date: | 2000-04-17 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change. J.Mol.Biol., 293, 1999
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1CU4
| CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE | Descriptor: | FAB HEAVY CHAIN, FAB LIGHT CHAIN, RECOGNITION PEPTIDE | Authors: | Kanyo, Z.F, Pan, K.M, Williamson, R.A, Burton, D.R, Prusiner, S.B, Fletterick, R.J, Cohen, F.E. | Deposit date: | 1999-08-20 | Release date: | 2000-04-17 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change. J.Mol.Biol., 293, 1999
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6DN1
| CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1151 SPLIT RNA | Descriptor: | 10-(6-carboxyhexyl)-8-(cyclopentylamino)-2,4-dihydroxy-7-methylbenzo[g]pteridin-10-ium, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Vicens, Q, Mondragon, E, Reyes, F.E, Berman, J, Kaur, H, Kells, K, Wickens, P, Wilson, J, Gadwood, R, Schostarez, H, Suto, R.K, Coish, P, Blount, K.F, Batey, R.T. | Deposit date: | 2018-06-05 | Release date: | 2018-09-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem. Biol., 13, 2018
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8EEX
| Cas7-11 in complex with Csx29 | Descriptor: | Cas7-11, Csx29, ZINC ION, ... | Authors: | Demircioglu, F.E, Wilkinson, M.E, Strecker, J, Li, D, Faure, G, Macrae, R.K, Zhang, F. | Deposit date: | 2022-09-07 | Release date: | 2022-11-16 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | RNA-activated protein cleavage with a CRISPR-associated endopeptidase. Science, 378, 2022
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8EEY
| Cas7-11 in complex with DR-mismatched target RNA, Csx29 and Csx30 | Descriptor: | Cas7-11, Csx29, Csx30, ... | Authors: | Demircioglu, F.E, Wilkinson, M.E, Strecker, J, Li, D, Faure, G, Macrae, R.K, Zhang, F. | Deposit date: | 2022-09-07 | Release date: | 2022-11-16 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | RNA-activated protein cleavage with a CRISPR-associated endopeptidase. Science, 378, 2022
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6OIF
| Cryo-EM structure of human TorsinA filament | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Torsin-1A | Authors: | Zheng, W, Demircioglu, F.E, Schwartz, T.U, Egelman, E.H. | Deposit date: | 2019-04-09 | Release date: | 2019-07-24 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn. Nat Commun, 10, 2019
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5MRG
| Solution structure of TDP-43 (residues 1-102) | Descriptor: | TAR DNA-binding protein 43 | Authors: | Mompean, M, Romano, V, Pantoja-Uceda, D, Stuani, C, Baralle, F.E, Laurents, D.V. | Deposit date: | 2016-12-22 | Release date: | 2017-06-07 | Last modified: | 2017-07-26 | Method: | SOLUTION NMR | Cite: | Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions. J. Biol. Chem., 292, 2017
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2XO1
| xpt-pbuX C74U Riboswitch from B. subtilis bound to N6-methyladenine | Descriptor: | ACETATE ION, COBALT HEXAMMINE(III), Guanine riboswitch, ... | Authors: | Daldrop, P, Reyes, F.E, Robinson, D.A, Hammond, C.M, Lilley, D.M.J, Batey, R.T, Brenk, R. | Deposit date: | 2010-08-09 | Release date: | 2011-04-06 | Last modified: | 2018-06-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Novel ligands for a purine riboswitch discovered by RNA-ligand docking. Chem. Biol., 18, 2011
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2XNZ
| xpt-pbuX C74U Riboswitch from B. subtilis bound to acetoguanamine identified by virtual screening | Descriptor: | 6-METHYL-1,3,5-TRIAZINE-2,4-DIAMINE, ACETATE ION, COBALT HEXAMMINE(III), ... | Authors: | Daldrop, P, Reyes, F.E, Robinson, D.A, Hammond, C.M, Lilley, D.M.J, Batey, R.T, Brenk, R. | Deposit date: | 2010-08-06 | Release date: | 2011-04-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Novel ligands for a purine riboswitch discovered by RNA-ligand docking. Chem. Biol., 18, 2011
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2XO0
| xpt-pbuX C74U Riboswitch from B. subtilis bound to 24-diamino-1,3,5- triazine identified by virtual screening | Descriptor: | 1,3,5-TRIAZINE-2,4-DIAMINE, ACETATE ION, COBALT HEXAMMINE(III), ... | Authors: | Daldrop, P, Reyes, F.E, Robinson, D.A, Hammond, C.M, Lilley, D.M.J, Batey, R.T, Brenk, R. | Deposit date: | 2010-08-09 | Release date: | 2011-04-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Novel ligands for a purine riboswitch discovered by RNA-ligand docking. Chem. Biol., 18, 2011
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2XNW
| XPT-PBUX C74U RIBOSWITCH FROM B. SUBTILIS BOUND TO A TRIAZOLO- TRIAZOLE-DIAMINE LIGAND IDENTIFIED BY VIRTUAL SCREENING | Descriptor: | 3,6-diamino-1,5-dihydro[1,2,4]triazolo[4,3-b][1,2,4]triazol-4-ium, ACETATE ION, COBALT HEXAMMINE(III), ... | Authors: | Daldrop, P, Reyes, F.E, Robinson, D.A, Hammond, C.M, Lilley, D.M.J, Brenk, R. | Deposit date: | 2010-08-06 | Release date: | 2011-04-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Novel ligands for a purine riboswitch discovered by RNA-ligand docking. Chem. Biol., 18, 2011
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5NGZ
| Ube2T in complex with fragment EM04 | Descriptor: | 1-(1,3-benzothiazol-2-yl)methanamine, Ubiquitin-conjugating enzyme E2 T | Authors: | Morreale, F.E, Bortoluzzi, A, Chaugule, V.K, Arkinson, C, Walden, H, Ciulli, A. | Deposit date: | 2017-03-21 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening. J. Med. Chem., 60, 2017
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7JPN
| Cryo-EM structure of Arpin-bound Arp2/3 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... | Authors: | van Eeuwen, T, Fregoso, F.E, Dominguez, R, Zimmet, A, Boczkowska, M, Rebowski, G. | Deposit date: | 2020-08-09 | Release date: | 2022-02-09 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Molecular mechanism of Arp2/3 complex inhibition by Arpin. Nat Commun, 13, 2022
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6GBM
| Solution structure of FUS-RRM bound to stem-loop RNA | Descriptor: | RNA (5'-R(*GP*GP*CP*AP*GP*AP*UP*UP*AP*CP*AP*AP*UP*UP*CP*UP*AP*UP*UP*UP*GP*CP*C)-3'), RNA-binding protein FUS | Authors: | Loughlin, F.E, Allain, F.H.-T. | Deposit date: | 2018-04-15 | Release date: | 2019-02-20 | Last modified: | 2019-05-08 | Method: | SOLUTION NMR | Cite: | The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity. Mol. Cell, 73, 2019
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6G99
| Solution structure of FUS-ZnF bound to UGGUG | Descriptor: | RNA (5'-R(*UP*GP*GP*UP*G)-3'), RNA-binding protein FUS, ZINC ION | Authors: | Loughlin, F.E, Allain, F.H.-T. | Deposit date: | 2018-04-10 | Release date: | 2019-02-20 | Last modified: | 2019-05-08 | Method: | SOLUTION NMR | Cite: | The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity. Mol. Cell, 73, 2019
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5O0U
| Crystal structure of tarantula venom peptide Protoxin-II | Descriptor: | 1,2-ETHANEDIOL, Beta/omega-theraphotoxin-Tp2a, CHLORIDE ION | Authors: | Tabor, A, McCarthy, S, Reyes, F.E. | Deposit date: | 2017-05-17 | Release date: | 2017-09-13 | Last modified: | 2019-03-27 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7. J.Am.Chem.Soc., 139, 2017
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5OJJ
| Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Ubiquitin-conjugating enzyme E2 T, ... | Authors: | Morreale, F.E, Testa, A, Chaugule, V.K, Bortoluzzi, A, Ciulli, A, Walden, H. | Deposit date: | 2017-07-21 | Release date: | 2017-10-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements. J. Med. Chem., 60, 2017
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5HCL
| Crystal Structure of the first bromodomain of BRD4 in complex with DMA | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N},~{N}-dimethylethanamide | Authors: | Dong, J, Weber, F.E, Caflisch, A. | Deposit date: | 2016-01-04 | Release date: | 2017-01-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment. Sci Rep, 7, 2017
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1A4J
| DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR | Descriptor: | IMMUNOGLOBULIN, DIELS ALDER CATALYTIC ANTIBODY (HEAVY CHAIN), DIELS ALDER CATALYTIC ANTIBODY (LIGHT CHAIN) | Authors: | Spiller, B.W, Romesburg, F.E, Schultz, P.G, Stevens, R.C. | Deposit date: | 1998-01-30 | Release date: | 1998-05-13 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science, 279, 1998
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1A4K
| DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE | Descriptor: | ANTIBODY FAB, CADMIUM ION, [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID | Authors: | Spiller, B.W, Romesburg, F.E, Schultz, P.G, Stevens, R.C. | Deposit date: | 1998-01-30 | Release date: | 1998-05-13 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science, 279, 1998
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1B07
| CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR | Descriptor: | PHENYLETHANE, PROTEIN (PROTO-ONCOGENE CRK (CRK)), PROTEIN (SH3 PEPTOID INHIBITOR) | Authors: | Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A. | Deposit date: | 1998-11-17 | Release date: | 1999-01-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science, 282, 1998
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3NPQ
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3NPN
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4GMA
| Crystal structure of the adenosylcobalamin riboswitch | Descriptor: | Adenosylcobalamin, Adenosylcobalamin riboswitch | Authors: | Reyes, F.E, Johnson, J.E, Polaski, J.T, Batey, R.T. | Deposit date: | 2012-08-15 | Release date: | 2012-10-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.94 Å) | Cite: | B12 cofactors directly stabilize an mRNA regulatory switch. Nature, 492, 2012
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