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8TAH
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BU of 8tah by Molmil
Cryo-EM structure of Cortactin-bound to Arp2/3 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ...
Authors:Fregoso, F.E, van Eeuwen, T, Dominguez, R.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins.
Nat Commun, 14, 2023
6DN1
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BU of 6dn1 by Molmil
CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1151 SPLIT RNA
Descriptor: 10-(6-carboxyhexyl)-8-(cyclopentylamino)-2,4-dihydroxy-7-methylbenzo[g]pteridin-10-ium, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Vicens, Q, Mondragon, E, Reyes, F.E, Berman, J, Kaur, H, Kells, K, Wickens, P, Wilson, J, Gadwood, R, Schostarez, H, Suto, R.K, Coish, P, Blount, K.F, Batey, R.T.
Deposit date:2018-06-05
Release date:2018-09-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch.
ACS Chem. Biol., 13, 2018
6OIF
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BU of 6oif by Molmil
Cryo-EM structure of human TorsinA filament
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Torsin-1A
Authors:Zheng, W, Demircioglu, F.E, Schwartz, T.U, Egelman, E.H.
Deposit date:2019-04-09
Release date:2019-07-24
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn.
Nat Commun, 10, 2019
5MRG
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BU of 5mrg by Molmil
Solution structure of TDP-43 (residues 1-102)
Descriptor: TAR DNA-binding protein 43
Authors:Mompean, M, Romano, V, Pantoja-Uceda, D, Stuani, C, Baralle, F.E, Laurents, D.V.
Deposit date:2016-12-22
Release date:2017-06-07
Last modified:2017-07-26
Method:SOLUTION NMR
Cite:Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
J. Biol. Chem., 292, 2017
5NGZ
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BU of 5ngz by Molmil
Ube2T in complex with fragment EM04
Descriptor: 1-(1,3-benzothiazol-2-yl)methanamine, Ubiquitin-conjugating enzyme E2 T
Authors:Morreale, F.E, Bortoluzzi, A, Chaugule, V.K, Arkinson, C, Walden, H, Ciulli, A.
Deposit date:2017-03-21
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
J. Med. Chem., 60, 2017
6GBM
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BU of 6gbm by Molmil
Solution structure of FUS-RRM bound to stem-loop RNA
Descriptor: RNA (5'-R(*GP*GP*CP*AP*GP*AP*UP*UP*AP*CP*AP*AP*UP*UP*CP*UP*AP*UP*UP*UP*GP*CP*C)-3'), RNA-binding protein FUS
Authors:Loughlin, F.E, Allain, F.H.-T.
Deposit date:2018-04-15
Release date:2019-02-20
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.
Mol. Cell, 73, 2019
6G99
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BU of 6g99 by Molmil
Solution structure of FUS-ZnF bound to UGGUG
Descriptor: RNA (5'-R(*UP*GP*GP*UP*G)-3'), RNA-binding protein FUS, ZINC ION
Authors:Loughlin, F.E, Allain, F.H.-T.
Deposit date:2018-04-10
Release date:2019-02-20
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.
Mol. Cell, 73, 2019
5O0U
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BU of 5o0u by Molmil
Crystal structure of tarantula venom peptide Protoxin-II
Descriptor: 1,2-ETHANEDIOL, Beta/omega-theraphotoxin-Tp2a, CHLORIDE ION
Authors:Tabor, A, McCarthy, S, Reyes, F.E.
Deposit date:2017-05-17
Release date:2017-09-13
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.
J.Am.Chem.Soc., 139, 2017
5OJJ
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BU of 5ojj by Molmil
Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Ubiquitin-conjugating enzyme E2 T, ...
Authors:Morreale, F.E, Testa, A, Chaugule, V.K, Bortoluzzi, A, Ciulli, A, Walden, H.
Deposit date:2017-07-21
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
J. Med. Chem., 60, 2017
5HCL
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BU of 5hcl by Molmil
Crystal Structure of the first bromodomain of BRD4 in complex with DMA
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N},~{N}-dimethylethanamide
Authors:Dong, J, Weber, F.E, Caflisch, A.
Deposit date:2016-01-04
Release date:2017-01-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.
Sci Rep, 7, 2017
7JPN
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BU of 7jpn by Molmil
Cryo-EM structure of Arpin-bound Arp2/3 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ...
Authors:van Eeuwen, T, Fregoso, F.E, Dominguez, R, Zimmet, A, Boczkowska, M, Rebowski, G.
Deposit date:2020-08-09
Release date:2022-02-09
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Molecular mechanism of Arp2/3 complex inhibition by Arpin.
Nat Commun, 13, 2022
8EEY
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BU of 8eey by Molmil
Cas7-11 in complex with DR-mismatched target RNA, Csx29 and Csx30
Descriptor: Cas7-11, Csx29, Csx30, ...
Authors:Demircioglu, F.E, Wilkinson, M.E, Strecker, J, Li, D, Faure, G, Macrae, R.K, Zhang, F.
Deposit date:2022-09-07
Release date:2022-11-16
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.53 Å)
Cite:RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
Science, 378, 2022
8EEX
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BU of 8eex by Molmil
Cas7-11 in complex with Csx29
Descriptor: Cas7-11, Csx29, ZINC ION, ...
Authors:Demircioglu, F.E, Wilkinson, M.E, Strecker, J, Li, D, Faure, G, Macrae, R.K, Zhang, F.
Deposit date:2022-09-07
Release date:2022-11-16
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
Science, 378, 2022
1A4J
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BU of 1a4j by Molmil
DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR
Descriptor: IMMUNOGLOBULIN, DIELS ALDER CATALYTIC ANTIBODY (HEAVY CHAIN), DIELS ALDER CATALYTIC ANTIBODY (LIGHT CHAIN)
Authors:Spiller, B.W, Romesburg, F.E, Schultz, P.G, Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
1A4K
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BU of 1a4k by Molmil
DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE
Descriptor: ANTIBODY FAB, CADMIUM ION, [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID
Authors:Spiller, B.W, Romesburg, F.E, Schultz, P.G, Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
2PK8
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BU of 2pk8 by Molmil
Crystal structure of an uncharacterized protein PF0899 from Pyrococcus furiosus
Descriptor: GOLD (I) CYANIDE ION, Uncharacterized protein PF0899
Authors:Liu, Z.J, Tempel, W, Chen, L, Shah, A, Lee, D, Clancy-Kelley, L.L, Dillard, B.D, Rose, J.P, Sugar, F.J, Jenny Jr, F.E, Lee, H.S, Izumi, M, Shah, C, Poole III, F.L, Adams, M.W.W, Richardson, J.S, Richardson, D.C, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2007-04-17
Release date:2007-05-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 A resolution.
Acta Crystallogr.,Sect.F, 63, 2007
1B07
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BU of 1b07 by Molmil
CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
Descriptor: PHENYLETHANE, PROTEIN (PROTO-ONCOGENE CRK (CRK)), PROTEIN (SH3 PEPTOID INHIBITOR)
Authors:Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A.
Deposit date:1998-11-17
Release date:1999-01-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Science, 282, 1998
2SEM
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BU of 2sem by Molmil
SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
Descriptor: PROTEIN (SEX MUSCLE ABNORMAL PROTEIN 5), PROTEIN (SH3 PEPTOID INHIBITOR)
Authors:Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A.
Deposit date:1998-11-02
Release date:1999-01-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Science, 282, 1998
5TY4
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BU of 5ty4 by Molmil
MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution
Descriptor: TGF-beta receptor type-2, mmTGF-b2-7m
Authors:Weiss, S.C, de la Cruz, M.J, Hattne, J, Shi, D, Reyes, F.E, Callero, G, Gonen, T.
Deposit date:2016-11-18
Release date:2017-04-26
Last modified:2023-10-04
Method:ELECTRON CRYSTALLOGRAPHY (2.9 Å)
Cite:Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
7AA4
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BU of 7aa4 by Molmil
Structure of ClpC1-NTD bound to a CymA analogue
Descriptor: Negative regulator of genetic competence ClpC/mecB, polymer Cyclomarin A analogue
Authors:Meinhart, A, Morreale, F.E, Kaiser, M, Clausen, T.
Deposit date:2020-09-03
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:BacPROTACs mediate targeted protein degradation in bacteria.
Cell, 185, 2022
7ABR
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BU of 7abr by Molmil
Cryo-EM structure of B. subtilis ClpC (DWB mutant) hexamer bound to a substrate polypeptide
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Negative regulator of genetic competence ClpC/MecB, ...
Authors:Morreale, F.E, Meinhart, A, Haselbach, D, Clausen, T.
Deposit date:2020-09-08
Release date:2021-10-06
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:BacPROTACs mediate targeted protein degradation in bacteria.
Cell, 185, 2022
3ZHN
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BU of 3zhn by Molmil
Crystal structure of the T6SS lipoprotein TssJ1 from Pseudomonas aeruginosa
Descriptor: IODIDE ION, PA_0080
Authors:Robb, C.S, Assmus, M, Nano, F.E, Boraston, A.B.
Deposit date:2012-12-22
Release date:2013-06-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the T6Ss Lipoprotein Tssj1 from Pseudomonas Aeruginosa.
Acta Crystallogr.,Sect.F, 69, 2013
6CSF
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BU of 6csf by Molmil
Crystal structure of sodium/alanine symporter AgcS with D-alanine bound
Descriptor: D-ALANINE, Monoclonal antibody FAB heavy chain, Monoclonal antibody FAB light chain, ...
Authors:Ma, J, Reyes, F.E, Gonen, T.
Deposit date:2018-03-20
Release date:2019-01-30
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6CSE
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BU of 6cse by Molmil
Crystal structure of sodium/alanine symporter AgcS with L-alanine bound
Descriptor: ALANINE, Monoclonal antibody FAB heavy chain, Monoclonal antibody FAB light chain, ...
Authors:Ma, J, Reyes, F.E, Gonen, T.
Deposit date:2018-03-20
Release date:2019-01-30
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
4ACK
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BU of 4ack by Molmil
3D Structure of DotU from Francisella novicida
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, TSSL
Authors:Robb, C.S, Nano, F.E, Boraston, A.B.
Deposit date:2011-12-15
Release date:2012-04-25
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Structure of the Conserved Type Six Secretion Protein Tssl (Dotu) from Francisella Novicida
J.Mol.Biol., 419, 2012

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