Author results

1YOC
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CRYSTAL STRUCTURE OF GENOMICS APC5556
Descriptor:hypothetical protein PA1835, GLYCEROL
Authors:Dong, A., Evdokimova, E., Kudritskam, M., Zhang, R.G., Yakunin, A., Pai, E., Edwards, A., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2005-01-27
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of genomics AFPA1835 by Sulfur SAD methods
To be Published
3CUO
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CRYSTAL STRUCTURE OF THE PREDICTED DNA-BINDING TRANSCRIPTIONAL REGULATOR FROM E. COLI
Descriptor:Uncharacterized HTH-type transcriptional regulator ygaV
Authors:Zhang, R., Evdokimova, E., Kagan, O., Savchenko, A., Edwards, A.M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2008-04-16
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the predicted DNA-binding transcriptional regulator from E. coli.
To be Published
3HFU
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CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF E. COLI CYNR WITH ITS SPECIFIC EFFECTOR AZIDE
Descriptor:HTH-type transcriptional regulator cynR, AZIDE ION, 1,2-ETHANEDIOL
Authors:Singer, A.U., Evdokimova, E., Kagan, O., Dong, A., Edwards, A.M., Savchenko, A.
Deposit date:2009-05-12
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the ligand binding domain of E. coli CynR with its specific effector azide
TO BE PUBLISHED
3HHL
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CRYSTAL STRUCTURE OF METHYLATED RPA0582 PROTEIN
Descriptor:RPA0582, SULFATE ION, CHLORIDE ION, ...
Authors:Sledz, P., Niedzialkowska, E., Chruszcz, M., Porebski, P., Yim, V., Kudritska, M., Zimmerman, M.D., Evdokimova, E., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
Deposit date:2009-05-15
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of methylated RPA0582 protein
To be Published
3UZR
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(2'')-IB, APO FORM
Descriptor:Aminoglycoside phosphotransferase, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Stogios, P.J., Minasov, G., Singer, A.U., Tan, K., Nocek, B., Evdokimova, E., Egorova, E., Di Leo, R., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-12-07
Release date:2011-12-21
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of aminoglycoside phosphotransferase APH(2'')-Ib, apo form
TO BE PUBLISHED
1RYL
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THE CRYSTAL STRUCTURE OF A PROTEIN OF UNKNOWN FUNCTION YFBM FROM ESCHERICHIA COLI
Descriptor:Hypothetical protein yfbM
Authors:Zhang, R., Evdokimova, E., Savchenko, A., Edwards, A., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2003-12-22
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:1.6A crystal structure of a hypothetical protein yfbM from E. coli
To be Published
3BRQ
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI TRANSCRIPTIONAL REPRESSOR ASCG
Descriptor:HTH-type transcriptional regulator ascG, FRUCTOSE, SULFATE ION, ...
Authors:Singer, A.U., Kagan, O., Evdokimova, E., Osipiuk, J., Joachimiak, A., Edwards, A.M., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-12-21
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the E. coli transcriptional repressor ascG.
To be Published
1SU1
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF YFCE, A PHOSPHOESTERASE FROM E. COLI
Descriptor:Hypothetical protein yfcE, ZINC ION, SULFATE ION
Authors:Miller, D.J., Shuvalova, L., Evdokimova, E., Savchenko, A., Yakunin, A., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2004-03-25
Release date:2004-08-17
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene.
Protein Sci., 16, 2007
1YSP
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF E. COLI TRANSCRIPTIONAL REGULATOR KDGR.
Descriptor:Transcriptional regulator kdgR, SULFATE ION
Authors:Bochkarev, A., Lunin, V.V., Ezersky, A., Evdokimova, E., Skarina, T., Xu, X., Borek, D., Joachimiak, A., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2005-02-08
Release date:2005-03-22
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural study of effector binding specificity in IclR transcriptional regulators
To be Published
2HXR
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STRUCTURE OF THE LIGAND BINDING DOMAIN OF E. COLI CYNR, A TRANSCRIPTIONAL REGULATOR CONTROLLING CYANATE METABOLISM
Descriptor:HTH-type transcriptional regulator cynR
Authors:Singer, A.U., Cuff, M.E., Evdokimova, E., Kagan, O., Joachimiak, A., Edwards, A.M., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2006-08-03
Release date:2006-08-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The structure of CynR, a transcriptional regulator, both in the presence and absence of sodium azide, its activator ligand
To be Published
4DBX
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(2")-ID/APH(2")-IVA
Descriptor:APH(2")-ID
Authors:Stogios, P.J., Minasov, G., Tan, K., Nocek, B., Singer, A.U., Evdokimova, E., Egorova, E., Di Leo, R., Li, H., Shakya, T., Wright, G.D., Savchenko, A., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2012-01-16
Release date:2012-02-01
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:A small molecule discrimination map of the antibiotic resistance kinome.
Chem.Biol., 18, 2011
4DFB
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(2")-ID/APH(2")-IVA IN COMPLEX WITH KANAMYCIN
Descriptor:APH(2")-Id, KANAMYCIN A, CHLORIDE ION
Authors:Stogios, P.J., Minasov, G., Osipiuk, J., Evdokimova, E., Egorova, E., Di leo, R., Li, H., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-01-23
Release date:2012-02-08
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A small molecule discrimination map of the antibiotic resistance kinome.
Chem.Biol., 18, 2011
4DFU
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INHIBITION OF AN ANTIBIOTIC RESISTANCE ENZYME: CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(2")-ID/APH(2")-IVA IN COMPLEX WITH KANAMYCIN INHIBITED WITH QUERCETIN
Descriptor:APH(2")-Id, KANAMYCIN A, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ...
Authors:Stogios, P.J., Minasov, G., Dong, A., Evdokimova, E., Egorova, E., Di Leo, R., Li, H., Shakya, T., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-01-24
Release date:2012-02-08
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A small molecule discrimination map of the antibiotic resistance kinome.
Chem.Biol., 18, 2011
5US1
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE ACETYLTRANSFERASE AAC(2')-IA IN COMPLEX WITH N2'-ACETYLGENTAMICIN C1A AND COENZYME A
Descriptor:Aminoglycoside 2'-N-acetyltransferase, (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-(acetylamino)-6-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranoside, D(-)-TARTARIC ACID, ...
Authors:Stogios, P.J., Evdokimova, E., Xu, Z., Wawrzak, Z., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-02-13
Release date:2017-03-15
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.
ACS Infect Dis, 4, 2018
6CD7
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CRYSTAL STRUCTURE OF APH(2")-IVA IN COMPLEX WITH PLAZOMICIN
Descriptor:APH(2'')-Id, CHLORIDE ION, (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
Authors:Stogios, P.J., Evdokimova, E., Dong, A., Di Leo, R., Savchenko, A., Satchell, K.J., Joachimiak, J., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2018-02-08
Release date:2018-02-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.
ACS Infect Dis, 4, 2018
1KTN
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STRUCTURAL GENOMICS, PROTEIN EC1535
Descriptor:2-deoxyribose-5-phosphate aldolase
Authors:Zhang, R., Joachimiak, A., Edwards, A., Skarina, T., Evdokimova, E., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2002-01-16
Release date:2002-08-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The 1.5A crystal structure of 2-deoxyribose-5-phosphate aldlase
To be Published
1KXJ
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THE CRYSTAL STRUCTURE OF GLUTAMINE AMIDOTRANSFERASE FROM THERMOTOGA MARITIMA
Descriptor:Amidotransferase hisH, PHOSPHATE ION
Authors:Korolev, S., Skarina, T., Evdokimova, E., Beasley, S., Edwards, A., Joachimiak, A., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2002-01-31
Release date:2002-03-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of glutamine amidotransferase from Thermotoga maritima
Proteins, 49, 2002
1NN4
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STRUCTURAL GENOMICS, RPIB/ALSB
Descriptor:Ribose 5-phosphate isomerase B
Authors:Zhang, R.G., Andersson, C.E., Mowbray, S.L., Savchenko, A., Skarina, T., Evdokimova, E., Beasley, S.L., Arrowsmith, C., Edwards, A.M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2003-01-12
Release date:2003-07-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction.
J.Mol.Biol., 332, 2003
1O8B
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STRUCTURE OF ESCHERICHIA COLI RIBOSE-5-PHOSPHATE ISOMERASE, RPIA, COMPLEXED WITH ARABINOSE-5-PHOSPHATE.
Descriptor:RIBOSE 5-PHOSPHATE ISOMERASE, BETA-D-ARABINOFURANOSE-5'-PHOSPHATE
Authors:Zhang, R.-g., Andersson, C.E., Savchenko, A., Skarina, T., Evdokimova, E., Beasley, S., Arrowsmith, C.H., Edwards, A.M., Joachimiak, A., Mowbray, S.L., Midwest Center for Structural Genomics (MCSG)
Deposit date:2002-11-26
Release date:2003-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structure of Escherichia Coli Ribose-5-Phosphate Isomerase: A Ubiquitous Enzyme of the Pentose Phosphate Pathway and the Calvin Cycle
Structure, 11, 2003
1P9Q
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STRUCTURE OF A HYPOTHETICAL PROTEIN AF0491 FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Hypothetical protein AF0491
Authors:Savchenko, A., Evdokimova, E., Skarina, T., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A.
Deposit date:2003-05-12
Release date:2004-06-08
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.
J.Biol.Chem., 280, 2005
1QW2
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CRYSTAL STRUCTURE OF A PROTEIN OF UNKNOWN FUNCTION TA1206 FROM THERMOPLASMA ACIDOPHILUM
Descriptor:conserved hypothetical protein TA1206
Authors:Savchenko, A., Evdokimova, E., Kudrytska, M., Edwards, A.E., Christendat, D., Midwest Center for Structural Genomics (MCSG)
Deposit date:2003-08-30
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of a Hypothetical Protein "TA1206" from Thermoplasma acidophilum
To be Published
1RLK
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STRUCTURE OF CONSERVED PROTEIN OF UNKNOWN FUNCTION TA0108 FROM THERMOPLASMA ACIDOPHILUM
Descriptor:Hypothetical protein Ta0108, SULFATE ION, GLYCEROL
Authors:Osipiuk, J., Evdokimova, E., Savchenko, A., Edwards, A., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2003-11-25
Release date:2003-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of conserved hypothetical protein TA0108 from Thermoplasma acidophilum
To be Published
1SED
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CRYSTAL STRUCTURE OF PROTEIN OF UNKNOWN FUNCTION YHAL FROM BACILLUS SUBTILIS
Descriptor:Hypothetical protein yhaI, ZINC ION, SODIUM ION, ...
Authors:Kim, Y., Joachimiak, A., Evdokimova, E., Savchenko, A., Edwards, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2004-02-17
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of the Hypothetical Protein YhaI, APC1180 from Bacillus subtilis
To be Published
1SH8
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1.5 A CRYSTAL STRUCTURE OF A PROTEIN OF UNKNOWN FUNCTION PA5026 FROM PSEUDOMONAS AERUGINOSA, PROBABLE THIOESTERASE
Descriptor:hypothetical protein PA5026
Authors:Zhang, R., Evdokimova, E., Savchenko, A., Edwards, A., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2004-02-25
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:1.5A crystal structure of a hypothetical protein PA5026 from Pseudomonas aeruginosa
To be Published
1TE2
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PUTATIVE PHOSPHATASE YNIC FROM ESCHERICHIA COLI K12
Descriptor:2-deoxyglucose-6-P phosphatase, 2-PHOSPHOGLYCOLIC ACID, CALCIUM ION
Authors:Kim, Y., Joachimiak, A., Evdokimova, E., Savchenko, A., Edwards, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2004-05-24
Release date:2004-08-03
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal Structure of Putative Phosphatase Ynic from Escherichia coli K12
To be Published