Author results

2F57
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 5
分子名称:Serine/threonine-protein kinase PAK 7, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE
著者Eswaran, J., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Bray, J., Das, S., Savitsky, P., Smee, C., Burgess, N., Fedorov, O., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Weigelt, J., Sundstrom, M., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
登録日2005-11-25
公開日2005-12-13
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
Structure, 15, 2007
2VUW
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STRUCTURE OF HUMAN HASPIN KINASE DOMAIN
分子名称:SERINE/THREONINE-PROTEIN KINASE HASPIN, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
著者Eswaran, J., Murray, J.W., Filippakopoulos, P., Soundararajan, M., Pike, A.C.W., von Delft, F., Picaud, S., Keates, T., King, O., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Fedorov, O., Burgess-Brown, N., Bray, J., Knapp, S.
登録日2008-05-30
公開日2008-09-16
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and Functional Characterization of the Atypical Human Kinase Haspin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2BIJ
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED ENRICHED PHOSPHATASE)
分子名称:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION
著者Barr, A.J., Debreczeni, J.E., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S., von Delft, F.
登録日2005-01-21
公開日2005-03-17
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2BV5
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION
分子名称:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION, ...
著者Debreczeni, J.E., Barr, A.J., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2005-06-22
公開日2005-07-14
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2C30
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 6
分子名称:SERINE/THREONINE-PROTEIN KINASE PAK 6, PHOSPHATE ION, CHLORIDE ION
著者Filippakopoulos, P., Berridge, G., Bray, J., Burgess, N., Colebrook, S., Das, S., Eswaran, J., Gileadi, O., Papagrigoriou, E., Savitsky, P., Smee, C., Turnbull, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Knapp, S.
登録日2005-10-02
公開日2006-02-08
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
2C7S
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE KAPPA AT 1.95A RESOLUTION
分子名称:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA, ACETATE ION
著者Debreczeni, J.E., Ugochukwu, E., Eswaran, J., Barr, A., Das, S., Burgess, N., Gileadi, O., Longman, E., von Delft, F., Knapp, S., Sundstron, M., Arrowsmith, C., Weigelt, J., Edwards, A.
登録日2005-11-28
公開日2007-01-02
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
2CDZ
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 IN COMPLEX WITH CGP74514A
分子名称:SERINE/THREONINE-PROTEIN KINASE PAK 4, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE, SULFATE ION, ...
著者Debreczeni, J.E., Ugochukwu, E., Eswaran, J., Filippakopoulos, P., Das, S., Fedorov, O., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Knapp, S.
登録日2006-01-31
公開日2006-02-08
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
3IQ7
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CRYSTAL STRUCTURE OF HUMAN HASPIN IN COMPLEX WITH 5-IODOTUBERCIDIN
分子名称:Serine/threonine-protein kinase haspin, PHOSPHATE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
著者Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2009-08-19
公開日2009-09-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and functional characterization of the atypical human kinase haspin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2A3K
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE, PTPN7 (HEPTP, HEMATOPOIETIC PROTEIN TYROSINE PHOSPHATASE)
分子名称:protein tyrosine phosphatase, non-receptor type 7, isoform 1, ...
著者Barr, A., Turnbull, A.P., Das, S., Eswaran, J., Debreczeni, J.E., Longmann, E., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
登録日2005-06-24
公開日2005-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
2A8B
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE PHOSPHATASE RECEPTOR, TYPE R
分子名称:Receptor-type tyrosine-protein phosphatase R, CHLORIDE ION
著者Ugochukwu, E., Eswaran, J., Barr, A., Longman, E., Arrowsmith, C., Edwards, A., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
登録日2005-07-07
公開日2005-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem.J., 395, 2006
2BVA
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4
分子名称:P21-ACTIVATED KINASE 4
著者Debreczeni, J.E., Bunkoczi, G., Eswaran, J., Filippakopoulos, P., Das, S., Fedorov, O., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Knapp, S.
登録日2005-06-23
公開日2005-07-14
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
3DLZ
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CRYSTAL STRUCTURE OF HUMAN HASPIN IN COMPLEX WITH AMP
分子名称:Serine/threonine-protein kinase haspin, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
著者Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Murray, J.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wickstroem, M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2008-06-30
公開日2008-07-15
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure and functional characterization of the atypical human kinase haspin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2C47
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STRUCTURE OF CASEIN KINASE 1 GAMMA 2
分子名称:CASEIN KINASE 1 GAMMA 2 ISOFORM, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, MAGNESIUM ION
著者Bunkoczi, G., Rellos, P., Das, S., Ugochukwu, E., Fedorov, O., Sobott, F., Eswaran, J., Amos, A., Ball, L., von Delft, F., Bullock, A., Debreczeni, J., Turnbull, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2005-10-16
公開日2005-11-07
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Structure of Casein Kinase 1 Gamma 2
To be Published
2RF0
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CRYSTAL STRUCTURE OF HUMAN MIXED LINEAGE KINASE MAP3K10 SH3 DOMAIN
分子名称:Mitogen-activated protein kinase kinase kinase 10, 1,2-ETHANEDIOL
著者Ugochukwu, E., Eswaran, J., Elkins, J., Keates, T., Pike, A.C.W., Berridge, G., Savitsky, P., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
登録日2007-09-27
公開日2007-10-23
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of human Mixed lineage kinase MAP3K10 SH3 domain.
To be Published
2BZL
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION
分子名称:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 14, SULFATE ION, ...
著者Debreczeni, J.E., Barr, A., Eswaran, J., Das, S., Burgess, N., Longman, E., Fedorov, O., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Knapp, S.
登録日2005-08-18
公開日2005-09-13
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal Structure of Human Protein Tyrosine Phosphatase 14 (Ptpn14) at 1.65-A Resolution.
Proteins, 63, 2006
2J0I
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4
分子名称:SERINE/THREONINE-PROTEIN KINASE PAK 4, 1,2-ETHANEDIOL
著者Debreczeni, J.E., Eswaran, J., Ugochukwu, E., Papagrigoriou, E., Turnbull, A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Knapp, S.
登録日2006-08-03
公開日2006-08-17
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of the Human P21-Activated Kinase 4
To be Published
2JII
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STRUCTURE OF VACCINIA RELATED KINASE 3
分子名称:SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3, 1,2-ETHANEDIOL
著者Bunkoczi, G., Eswaran, J., Pike, A.C.W., Uppenberg, J., Ugochukwu, E., von Delft, F., Cooper, C., Salah, E., Savitsky, P., Burgess-Brown, N., Keates, T., Fedorov, O., Sobott, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
登録日2007-06-28
公開日2007-07-10
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.
Structure, 17, 2009
2ODB
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THE CRYSTAL STRUCTURE OF HUMAN CDC42 IN COMPLEX WITH THE CRIB DOMAIN OF HUMAN P21-ACTIVATED KINASE 6 (PAK6)
分子名称:Human Cell Division Cycle 42 (CDC42), Serine/threonine-protein kinase PAK 6, CHLORIDE ION, ...
著者Ugochukwu, E., Yang, X., Elkins, J., Soundararajan, M., Pike, A.C.W., Eswaran, J., Burgess, N., Debreczeni, J.E., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Gileadi, O., von Delft, F., Knapp, S., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-12-22
公開日2007-01-30
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)
To be Published
2Q0N
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STRUCTURE OF HUMAN P21 ACTIVATING KINASE 4 (PAK4) IN COMPLEX WITH A CONSENSUS PEPTIDE
分子名称:Serine/threonine-protein kinase PAK 4, Synthetic peptide, SULFATE ION, ...
著者Filippakopoulos, P., Eswaran, J., Turnbull, A., Papagrigoriou, E., Pike, A.W., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
登録日2007-05-22
公開日2007-06-26
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide.
To be Published
2V62
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STRUCTURE OF VACCINIA-RELATED KINASE 2
分子名称:SERINE/THREONINE-PROTEIN KINASE VRK2, MAGNESIUM ION, SUCCINIC ACID, ...
著者Bunkoczi, G., Eswaran, J., Cooper, C., Fedorov, O., Keates, T., Rellos, P., Salah, E., Savitsky, P., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
登録日2007-07-13
公開日2007-08-21
最終更新日2011-11-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the Pseudokinase Vrk3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site.
Structure, 17, 2009
3F2N
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CRYSTAL STRUCTURE OF HUMAN HASPIN WITH AN IMIDAZO-PYRIDAZINE LIGAND
分子名称:Serine/threonine-protein kinase haspin, (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol, PHOSPHATE ION, ...
著者Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Yue, W.W., Murray, J.W., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2008-10-30
公開日2008-12-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand
To be Published
3FMD
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CRYSTAL STRUCTURE OF HUMAN HASPIN WITH AN ISOQUINOLINE LIGAND
分子名称:Serine/threonine-protein kinase haspin, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, NICKEL (II) ION, ...
著者Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2008-12-21
公開日2008-12-30
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Human Haspin with an Isoquinoline ligand
To be Published
3NR9
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STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)
分子名称:Dual specificity protein kinase CLK2, (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one
著者Chaikuad, A., Savitsky, P., Krojer, T., Muniz, J.R.C., Filippakopoulos, P., Rellos, P., Keates, T., Fedorov, O., Pike, A.C.W., Eswaran, J., Berridge, G., Phillips, C., Zhang, Y., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2010-06-30
公開日2010-08-25
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structure of human CDC2-like kinase 2 (CLK2)
To be Published
3P1A
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STRUCTURE OF HUMAN MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE MYT1 (PKMYT1)
分子名称:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE
著者Chaikuad, A., Eswaran, J., Fedorov, O., Cooper, C.D.O., Kroeler, T., Vollmar, M., Krojer, T., Berridge, G., Muniz, J.R.C., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2010-09-30
公開日2010-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)
To be Published
4O38
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CRYSTAL STRUCTURE OF THE HUMAN CYCLIN G ASSOCIATED KINASE (GAK)
分子名称:Cyclin-G-associated kinase, SUCCINIC ACID, GLYCEROL
著者Zhang, R., Hatzos-Skintges, C., Weger, A., Chaikuad, A., Eswaran, J., Fedorov, O., King, O., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structural Genomics Consortium (SGC)
登録日2013-12-18
公開日2014-01-01
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Crystal structure of the human cyclin G associated kinase (GAK)
To be Published
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