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6N4Q
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CRYOEM STRUCTURE OF NAV1.7 VSD2 (ACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2
分子名称:Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ...
著者Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M.
登録日2018-11-20
公開日2019-01-23
最終更新日2019-02-20
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6N4R
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CRYOEM STRUCTURE OF NAV1.7 VSD2 (DEACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2
分子名称:Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ...
著者Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M.
登録日2018-11-20
公開日2019-01-23
最終更新日2019-02-20
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
2ANW
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EXPRESSION, CRYSTALLIZATION AND THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS
分子名称:plasma kallikrein, light chain, BENZAMIDINE
著者Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J.R., Young, W.B., McGrath, M.E., Katz, B.A.
登録日2005-08-11
公開日2005-10-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
2ANY
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EXPRESSION, CRYSTALLIZATION AND THE THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS
分子名称:plasma kallikrein, light chain, PHOSPHATE ION, ...
著者Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J.R., Young, W.B., McGrath, M.E., Katz, B.A.
登録日2005-08-11
公開日2005-10-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
4ERS
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A MOLECULAR BASIS FOR NEGATIVE REGULATION OF THE GLUCAGON RECEPTOR
分子名称:Fab light chain, Fab heavy chain, Glucagon receptor, ...
著者Murray, J.M., Koth, C.M., Mukund, S.
登録日2012-04-20
公開日2012-08-29
最終更新日2012-12-05
実験手法X-RAY DIFFRACTION (2.637 Å)
主引用文献Molecular basis for negative regulation of the glucagon receptor.
Proc.Natl.Acad.Sci.USA, 109, 2012
5KUP
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BRUTON'S TYROSINE KINASE (BTK) WITH PYRIDAZINONE COMPOUND 9
分子名称:Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ...
著者Eigenbrot, C., Yu, C.
登録日2016-07-13
公開日2016-09-14
最終更新日2016-11-02
実験手法X-RAY DIFFRACTION (1.389 Å)
主引用文献Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.
Acs Chem.Biol., 11, 2016
6E25
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NMR SOLUTION STRUCTURE OF THE CARD9 CARD BOUND TO ZINC
分子名称:Caspase recruitment domain-containing protein 9, ZINC ION
著者Holliday, M.J., Dueber, E.C., Fairbrother, W.J.
登録日2018-07-10
公開日2018-09-26
最終更新日2018-11-07
実験手法SOLUTION NMR
主引用文献Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E26
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NMR SOLUTION STRUCTURE OF THE CARD9 CARD
分子名称:Caspase recruitment domain-containing protein 9
著者Holliday, M.J., Dueber, E.C., Fairbrother, W.J.
登録日2018-07-10
公開日2018-09-26
最終更新日2018-11-07
実験手法SOLUTION NMR
主引用文献Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E27
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THE CARD9 CARD DOMAIN-SWAPPED DIMER WITH A ZINC ION BOUND TO ONE OF THE TWO ZINC BINDING SITES
分子名称:Caspase recruitment domain-containing protein 9, ZINC ION
著者Holliday, M.J., Ferrao, R., Boenig, G., Deuber, E.C., Fairbrother, W.J.
登録日2018-07-10
公開日2018-09-26
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.811 Å)
主引用文献Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E28
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THE CARD9 CARD DOMAIN-SWAPPED DIMER
分子名称:Caspase recruitment domain-containing protein 9
著者Holliday, M.J., Ferrao, R., Boenig, G., Deuber, E.C., Fairbrother, W.J.
登録日2018-07-10
公開日2018-09-26
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6N4I
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STRUCTURAL BASIS OF NAV1.7 INHIBITION BY A GATING-MODIFIER SPIDER TOXIN
分子名称:Nav1.7 VSD2-NavAb channel chimera protein, Beta/omega-theraphotoxin-Tp2a, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
著者Xu, H., Koth, C.M., Payandeh, J.
登録日2018-11-19
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (3.541 Å)
主引用文献Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
3SOB
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THE STRUCTURE OF THE FIRST YWTD BETA PROPELLER DOMAIN OF LRP6 IN COMPLEX WITH A FAB
分子名称:antibody light chain, Low-density lipoprotein receptor-related protein 6, antibody heavy chain, ...
著者Wang, W., Bourhis, E., Tam, C., Zhang, Y., Rouge, L., Wu, Y., Franke, Y., Cochran, A.G.
登録日2011-06-30
公開日2011-09-21
最終更新日2014-05-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
3SOQ
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THE STRUCTURE OF THE FIRST YWTD BETA PROPELLER DOMAIN OF LRP6 IN COMPLEX WITH A DKK1 PEPTIDE
分子名称:Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, N-ACETYL-D-GLUCOSAMINE, ...
著者Wang, W., Bourhis, E., Zhang, Y., Rouge, L., Wu, Y., Franke, Y., Cochran, A.G.
登録日2011-06-30
公開日2011-09-21
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
3SOV
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THE STRUCTURE OF A BETA PROPELLER DOMAIN IN COMPLEX WITH PEPTIDE S
分子名称:Low-density lipoprotein receptor-related protein 6, Sclerostin, N-ACETYL-D-GLUCOSAMINE, ...
著者Wang, W., Bourhis, E., Zhang, Y., Rouge, L., Wu, Y., Franke, Y., Cochran, A.G.
登録日2011-06-30
公開日2011-09-21
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
4KVN
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CRYSTAL STRUCTURE OF FAB 39.29 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ A/PERTH/16/2009 (H3N2)
分子名称:Hemagglutinin, Human IgG Heavy Chain, Human IgG Light Chain, ...
著者Fong, R., Swem, L.R., Lupardus, P.J.
登録日2013-05-22
公開日2013-08-07
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A Novel In vivo Human Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Anti-Influenza A Antibodies
Cell Host Microbe, 14, 2013
5EK0
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HUMAN NAV1.7-VSD4-NAVAB IN COMPLEX WITH GX-936.
分子名称:Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
著者Ahuja, S., Mukund, S., Starovasnik, M.A., Koth, C.M., Payandeh, J.
登録日2015-11-03
公開日2015-12-23
最終更新日2015-12-30
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science, 350, 2015