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4FBX
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BU of 4fbx by Molmil
Complex structure of human protein kinase CK2 catalytic subunit crystallized in the presence of a bisubstrate inhibitor
Descriptor: CHLORIDE ION, Casein kinase II subunit alpha, bisubstrate inhibitor
Authors:Enkvist, E, Viht, K, Bischoff, N, Vahter, J, Saaver, S, Raidaru, G, Issinger, O.-G, Niefind, K, Uri, A.
Deposit date:2012-05-23
Release date:2012-10-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.
Org.Biomol.Chem., 10, 2012
5IZJ
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BU of 5izj by Molmil
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1411
Descriptor: 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAR-DAR, 47P-AZ1-DAR-DAR-DAR, ...
Authors:Pflug, A, Enkvist, E, Uri, A, Engh, R.A.
Deposit date:2016-03-25
Release date:2016-07-20
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
Bioconjug.Chem., 27, 2016
5IZF
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BU of 5izf by Molmil
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1408
Descriptor: 6J9-ZEU-DAR-ACA-DAR-NH2, SULFATE ION, cAMP-dependent protein kinase catalytic subunit alpha
Authors:Pflug, A, Enkvist, E, Uri, A, Engh, R.A.
Deposit date:2016-03-25
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
Bioconjug.Chem., 27, 2016
6SPX
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BU of 6spx by Molmil
Structure of protein kinase CK2 catalytic subunit in complex with the CK2beta-competitive bisubstrate inhibitor ARC1502
Descriptor: 8-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]octanoic acid, ARC1502, Casein kinase II subunit alpha
Authors:Niefind, K, Schnitzler, A.
Deposit date:2019-09-03
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.
Bioorg.Chem., 96, 2020
6SPW
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BU of 6spw by Molmil
Structure of protein kinase CK2 catalytic subunit with the CK2beta-competitive bisubstrate inhibitor ARC3140
Descriptor: 8-[4,5,6,7-tetrakis(iodanyl)benzimidazol-1-yl]octanoic acid, ARC3140, Casein kinase II subunit alpha, ...
Authors:Niefind, K, Schnitzler, A.
Deposit date:2019-09-03
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.
Bioorg.Chem., 96, 2020
3BWJ
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BU of 3bwj by Molmil
Complex of PKA with the bisubstrate protein kinase inhibitor lead compound Arc-1034
Descriptor: (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-(6-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]amino}-6-oxohexyl)-3,4-dihydroxytetrahydrofuran-2-carboxamide, cAMP-dependent protein kinase, alpha-catalytic subunit
Authors:Lavogina, D, Koenig, N, Uri, A, Bossemeyer, D.
Deposit date:2008-01-09
Release date:2009-02-03
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases.
J.Med.Chem., 52, 2009
5J5X
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BU of 5j5x by Molmil
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1416
Descriptor: 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAL-DAR-DAR-DAR-DAR, SULFATE ION, ...
Authors:Alam, K.A, Ivan, T, Uri, A, Engh, R.A.
Deposit date:2016-04-04
Release date:2016-07-20
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
Bioconjug.Chem., 27, 2016
7OOX
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BU of 7oox by Molmil
Crystal structure of PIM1 in complex with ARC-3126
Descriptor: 1,2-ETHANEDIOL, Inhibitor ARC-3126, PHOSPHATE ION, ...
Authors:Chaikuad, A, Dixon-Clarke, S.E, Nonga, O.E, Uri, A, Bullock, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-05-28
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.
Molecules, 26, 2021
7OOV
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BU of 7oov by Molmil
Crystal structure of PIM1 in complex with ARC-1411
Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Serine/threonine-protein kinase pim-1, ...
Authors:Chaikuad, A, Dixon-Clarke, S.E, Nonga, O.E, Uri, A, Bullock, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-05-28
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.
Molecules, 26, 2021
7OOW
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BU of 7oow by Molmil
Crystal structure of PIM1 in complex with ARC-1415
Descriptor: 1,2-ETHANEDIOL, INHIBITOR ARC-1415, MAGNESIUM ION, ...
Authors:Chaikuad, A, Dixon-Clarke, S.E, Nonga, O.E, Uri, A, Bullock, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-05-28
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.
Molecules, 26, 2021
3AGL
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BU of 3agl by Molmil
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039
Descriptor: (10R,20R,23R)-1-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-20,23-bis(3-carbamimidamido propyl)-10-methyl-1,8,11,18,21-pentaoxo-2,9,12,19,22-pentaazatetracosan-24-amide, cAMP-dependent protein kinase catalytic subunit alpha
Authors:Pflug, A, Ragozina, J, Uri, A, Bossemeyer, D, Engh, R.A.
Deposit date:2010-04-02
Release date:2010-09-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
J.Mol.Biol., 403, 2010
3AGM
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BU of 3agm by Molmil
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670
Descriptor: N~2~-{8-OXO-8-[4-(9H-PURIN-6-YL)PIPERAZIN-1-YL]OCTANOYL}-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGININAMIDE, cAMP-dependent protein kinase catalytic subunit alpha
Authors:Pflug, A, Ragozina, J, Uri, A, Bossemeyer, D, Engh, R.A.
Deposit date:2010-04-02
Release date:2010-09-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
J.Mol.Biol., 403, 2010
3AG9
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BU of 3ag9 by Molmil
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1012
Descriptor: (10R,20R,23R)-10-(4-aminobutyl)-1-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-20,23-bis(3-carbamimidamidopropyl)-1,8,11,18,21-pentaoxo-2,9,12,19,22-pentaazatetracosan-24-amide, cAMP-dependent protein kinase catalytic subunit alpha
Authors:Pflug, A, Lavogina, D, Uri, A, Engh, R.A, Bossemeyer, D.
Deposit date:2010-03-26
Release date:2010-09-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
J.Mol.Biol., 403, 2010

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