Author results

3FZU
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IGG1 FAB CHARACTERIZED BY H/D EXCHANGE
Descriptor:immunoglobulin IgG1 Fab, light chain, heavy chain
Authors:Arndt, J., Houde, D., Domeier, W., Berkowitz, S., Engen, J.R.
Deposit date:2009-01-26
Release date:2009-03-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry.
Anal Chem, 81, 2009
4N4P
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CRYSTAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM MYCOPLASMA SYNOVIAE, CRYSTAL FORM I
Descriptor:Acylneuraminate lyase, CHLORIDE ION
Authors:Georgescauld, F., Popova, K., Gupta, A.J., Bracher, A., Engen, J.R., Hayer-Hartl, M., Hartl, F.U.
Deposit date:2013-10-08
Release date:2014-05-21
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GroEL/ES chaperonin modulates the mechanism and accelerates the rate of TIM-barrel domain folding.
Cell(Cambridge,Mass.), 157, 2014
4N4Q
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CRYSTAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM MYCOPLASMA SYNOVIAE, CRYSTAL FORM II
Descriptor:Acylneuraminate lyase
Authors:Georgescauld, F., Popova, K., Gupta, A.J., Bracher, A., Engen, J.R., Hayer-Hartl, M., Hartl, F.U.
Deposit date:2013-10-08
Release date:2014-05-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding.
Cell(Cambridge,Mass.), 157, 2014
6QA2
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R80A MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Nucleoside diphosphate kinase, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Dautant, A., Henri, J., Wales, T.E., Meyer, P., Engen, J.R., Georgescauld, F.
Deposit date:2018-12-18
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange.
Biochemistry, 58, 2019
2N3T
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SOLUTION STRUCTURE OF THE RPN1 SUBSTRATE RECEPTOR SITE TOROID 1 (T1)
Descriptor:26S proteasome regulatory subunit RPN1
Authors:Chen, X., Walters, K.J.
Deposit date:2015-06-10
Release date:2016-02-24
Last modified:2016-03-23
Method:SOLUTION NMR
Cite:Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.
Science, 351, 2016
2N3U
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SOLUTION STRUCTURE OF THE RPN1 T1 SITE ENGAGING TWO MONOUBIQUITIN MOLECULES
Descriptor:26S proteasome regulatory subunit RPN1, Ubiquitin-60S ribosomal protein L40
Authors:Chen, X., Walters, K.J.
Deposit date:2015-06-10
Release date:2016-02-24
Last modified:2016-03-23
Method:SOLUTION NMR
Cite:Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.
Science, 351, 2016
2N3V
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SOLUTION STRUCTURE OF THE RPN1 T1 SITE WITH K48-LINKED DIUBIQUITIN IN THE EXTENDED BINDING MODE
Descriptor:26S proteasome regulatory subunit RPN1, Ubiquitin-60S ribosomal protein L40
Authors:Chen, X., Walters, K.J.
Deposit date:2015-06-10
Release date:2016-02-24
Last modified:2016-03-23
Method:SOLUTION NMR
Cite:Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.
Science, 351, 2016
2N3W
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SOLUTION STRUCTURE OF THE RPN1 T1 SITE WITH K48-LINKED DIUBIQUITIN IN THE CONTRACTED BINDING MODE
Descriptor:26S proteasome regulatory subunit RPN1, Ubiquitin-60S ribosomal protein L40
Authors:Chen, X., Walters, K.J.
Deposit date:2015-06-10
Release date:2016-02-24
Last modified:2016-03-23
Method:SOLUTION NMR
Cite:Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.
Science, 351, 2016
3IKA
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CRYSTAL STRUCTURE OF EGFR 696-1022 T790M MUTANT COVALENTLY BINDING TO WZ4002
Descriptor:Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
Authors:Yun, C.-H., Eck, M.J.
Deposit date:2009-08-05
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Nature, 462, 2009
3K5V
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STRUCTURE OF ABL KINASE IN COMPLEX WITH IMATINIB AND GNF-2
Descriptor:Tyrosine-protein kinase ABL1, 3-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)benzamide, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ...
Authors:Cowan-Jacob, S.W., Fendrich, G., Rummel, G., Strauss, A.
Deposit date:2009-10-08
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Nature, 463, 2010
3MXO
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CRYSTAL STRUCTURE OH HUMAN PHOSPHOGLYCERATE MUTASE FAMILY MEMBER 5 (PGAM5)
Descriptor:Serine/threonine-protein phosphatase PGAM5, mitochondrial, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Alfano, I., Picaud, S., Filippakopoulos, P., Barr, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Takeda, K., Ichijo, H., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-05-07
Release date:2010-09-15
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.
Structure, 2017
3O0T
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CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLYCERATE MUTASE FAMILY MEMBER 5 (PGAM5) IN COMPLEX WITH PHOSPHATE
Descriptor:Serine/threonine-protein phosphatase PGAM5, mitochondrial, PHOSPHATE ION, ...
Authors:Chaikuad, A., Alfano, I., Picaud, S., Filippakopoulos, P., Barr, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Takeda, K., Ichijo, H., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-07-20
Release date:2010-10-06
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.
Structure, 2017
3UWP
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CRYSTAL STRUCTURE OF DOT1L IN COMPLEX WITH 5-IODOTUBERCIDIN
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
Authors:Yu, W., Tempel, W., Smil, D., Schapira, M., Li, Y., Vedadi, M., Nguyen, K.T., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2011-12-02
Release date:2012-03-14
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
3V79
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STRUCTURE OF HUMAN NOTCH1 TRANSCRIPTION COMPLEX INCLUDING CSL, RAM, ANK, AND MAML-1 ON HES-1 PROMOTER DNA SEQUENCE
Descriptor:Neurogenic locus notch homolog protein 1, Recombining binding protein suppressor of hairless, Mastermind-like protein 1, ...
Authors:Nam, Y., Sliz, P., Blacklow, S.
Deposit date:2011-12-20
Release date:2012-02-15
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes.
Structure, 20, 2012
4EQZ
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH INHIBITOR FED2
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, 5'-deoxy-5'-[(3-{[(4-methylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]adenosine, ...
Authors:Wernimont, A.K., Tempel, W., Yu, W., Li, Y., Nguyen, K.T., Federation, A., Marineau, J., Qi, J., Vedadi, M., Bradner, J.E., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2012-04-19
Release date:2012-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
4ER0
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH INHIBITOR FED1
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5'-deoxyadenosine, ...
Authors:Wernimont, A.K., Tempel, W., Yu, W., Li, Y., Nguyen, K.T., Federation, A., Marineau, J., Qi, J., Vedadi, M., Bradner, J.E., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2012-04-19
Release date:2012-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
4ER3
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH INHIBITOR EPZ004777
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ...
Authors:Wernimont, A.K., Tempel, W., Yu, W., Scopton, A., Li, Y., Nguyen, K.T., Federation, A., Marineau, J., Qi, J., Vedadi, M., Bradner, J.E., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2012-04-19
Release date:2012-05-16
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
4ER5
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH 2 MOLECULES OF EPZ004777
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ...
Authors:Wernimont, A.K., Tempel, W., Yu, W., Scopton, A., Li, Y., Nguyen, K.T., Federation, A., Marineau, J., Qi, J., Vedadi, M., Bradner, J.E., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2012-04-19
Release date:2012-05-16
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
4ER6
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH INHIBITOR SGC0946
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, BROMIDE ION, ...
Authors:Wernimont, A.K., Tempel, W., Yu, W., Scopton, A., Li, Y., Nguyen, K.T., Vedadi, M., Bradner, J.E., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2012-04-19
Release date:2012-05-16
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
4ER7
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH INHIBITOR SGC0947
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ...
Authors:Wernimont, A.K., Tempel, W., Yu, W., Scopton, A., Li, Y., Nguyen, K.T., Vedadi, M., Bradner, J.E., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2012-04-19
Release date:2012-05-16
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
5FFG
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CRYSTAL STRUCTURE OF INTEGRIN ALPHA V BETA 6 HEAD
Descriptor:Integrin alpha-V, Integrin beta-6, CALCIUM ION, ...
Authors:Dong, X., Springer, T.A.
Deposit date:2015-12-18
Release date:2017-01-25
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
5FFO
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INTEGRIN ALPHA V BETA 6 IN COMPLEX WITH PRO-TGF-BETA
Descriptor:Integrin alpha-V, Integrin beta-6, Transforming growth factor beta-1, ...
Authors:Dong, X., Zhao, B., Springer, T.A.
Deposit date:2015-12-18
Release date:2017-01-25
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
5MUF
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CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLYCERATE MUTASE FAMILY MEMBER 5 (PGAM5) IN ITS ENZYMATICALLY ACTIVE DODECAMERIC FORM INDUCED BY THE PRESENCE OF THE N-TERMINAL WDPNWD MOTIF
Descriptor:Serine/threonine-protein phosphatase PGAM5, mitochondrial, PHOSPHATE ION
Authors:Chaikuad, A., Alfano, I., Picaud, S., Filippakopoulos, P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2017-01-13
Release date:2017-07-12
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.
Structure, 25, 2017
5MW2
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CRYSTAL STRUCTURE OF BCL-6 BTB-DOMAIN WITH BI-3802
Descriptor:B-cell lymphoma 6 protein, 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide
Authors:Bader, G., Flotzinger, G., Weiss-Puxbaum, A., Zoephel, A.
Deposit date:2017-01-18
Release date:2017-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017
5MW6
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CRYSTAL STRUCTURE OF THE BCL6 BTB-DOMAIN WITH COMPOUND 1
Descriptor:B-cell lymphoma 6 protein, 5-chloranyl-~{N}-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-amine
Authors:Davies, D.R., Kessler, D.
Deposit date:2017-01-18
Release date:2017-10-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017
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