Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4WUY
DownloadVisualize
BU of 4wuy by Molmil
Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor
Descriptor: 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, GLYCEROL, N-lysine methyltransferase SMYD2, ...
Authors:Nguyen, H, Allali-Hassani, A, Antonysamy, S, Chang, S, Chen, L.H, Curtis, C, Emtage, S, Fan, L, Gheyi, T, Li, F, Liu, S, Martin, J.R, Mendel, D, Olsen, J.B, Pelletier, L, Shatseva, T, Wu, S, Zhang, F.F, Arrowsmith, C.H, Brown, P.J, Campbell, R.M, Garcia, B.A, Barsyte-Lovejoy, D, Mader, M, Vedadi, M.
Deposit date:2014-11-04
Release date:2015-04-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
J.Biol.Chem., 290, 2015
4GQB
DownloadVisualize
BU of 4gqb by Molmil
Crystal Structure of the human PRMT5:MEP50 Complex
Descriptor: (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid, Histone H4 peptide, Methylosome protein 50, ...
Authors:Antonysamy, S, Bonday, Z, Campbell, R, Doyle, B, Druzina, Z, Gheyi, T, Han, B, Jungheim, L.N, Qian, Y, Rauch, C, Russell, M, Sauder, J.M, Wasserman, S.R, Weichert, K, Willard, F.S, Zhang, A, Emtage, S.
Deposit date:2012-08-22
Release date:2012-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structure of the human PRMT5:MEP50 complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
3RU0
DownloadVisualize
BU of 3ru0 by Molmil
Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound
Descriptor: SET and MYND domain-containing protein 3, SINEFUNGIN, ZINC ION
Authors:Foreman, K.W, Brown, M, Park, F, Emtage, S, Harriss, J, Das, C, Zhu, L, Crew, A, Arnold, L, Shaaban, S, Tucker, P.
Deposit date:2011-05-04
Release date:2011-05-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3.
Plos One, 6, 2011
3GD7
DownloadVisualize
BU of 3gd7 by Molmil
Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
Descriptor: Fusion complex of Cystic fibrosis transmembrane conductance regulator, residues 1193-1427 and Maltose/maltodextrin import ATP-binding protein malK, residues 219-371, ...
Authors:Atwell, S, Antonysamy, S, Conners, K, Emtage, S, Gheyi, T, Lewis, H.A, Lu, F, Sauder, J.M, Wasserman, S.R, Zhao, X.
Deposit date:2009-02-23
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
2PZG
DownloadVisualize
BU of 2pzg by Molmil
Minimal human CFTR first nucleotide binding domain as a monomer
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ...
Authors:Atwell, S, Conners, K, Emtage, S, Gheyi, T, Glenn, N.R, Hendle, J, Lewis, H.A, Lu, F, Rodgers, L.A, Romero, R, Sauder, J.M, Smith, D, Tien, H, Wasserman, S.R, Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
DownloadVisualize
BU of 2pzf by Molmil
Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer with delta F508
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
Authors:Atwell, S, Conners, K, Emtage, S, Gheyi, T, Glenn, N.R, Hendle, J, Lewis, H.A, Lu, F, Rodgers, L.A, Romero, R, Sauder, J.M, Smith, D, Tien, H, Wasserman, S.R, Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZE
DownloadVisualize
BU of 2pze by Molmil
Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
Authors:Atwell, S, Conners, K, Emtage, S, Gheyi, T, Glenn, N.R, Hendle, J, Lewis, H.A, Lu, F, Rodgers, L.A, Romero, R, Sauder, J.M, Smith, D, Tien, H, Wasserman, S.R, Zhao, X.
Deposit date:2007-05-17
Release date:2007-10-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2HHL
DownloadVisualize
BU of 2hhl by Molmil
Crystal structure of the human small CTD phosphatase 3 isoform 1
Descriptor: 12-TUNGSTOPHOSPHATE, CTD small phosphatase-like protein
Authors:Malashkevich, V.N, Toro, R, Ramagopal, U, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-06-28
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural genomics of protein phosphatases.
J.STRUCT.FUNCT.GENOM., 8, 2007
2GDQ
DownloadVisualize
BU of 2gdq by Molmil
Crystal structure of mandelate racemase/muconate lactonizing enzyme from Bacillus subtilis at 1.8 A resolution
Descriptor: yitF
Authors:Malashkevich, V.N, Toro, R, Sauder, J.M, Schwinn, K.D, Emtage, S, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Burley, S.K, Sali, A, Babbitt, P, Pieper, U, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-03-16
Release date:2006-04-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of mandelate racemase/muconate lactonizing enzyme from Bacillus subtilis at 1.8 A resolution
To be Published
2GGE
DownloadVisualize
BU of 2gge by Molmil
Crystal Structure of Mandelate Racemase/Muconate Lactonizing Enzyme from Bacillus Subtilis complexed with MG++ at 1.8 A
Descriptor: CHLORIDE ION, MAGNESIUM ION, yitF
Authors:Malashkevich, V.N, Sauder, J.M, Schwinn, K.D, Emtage, S, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Burley, S.K, Sali, A, Babbitt, P, Pieper, U, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-03-23
Release date:2006-04-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structure of Mandelate Racemase/Muconate Lactonizing Enzyme from Bacillus Subtilis complexed with MG++ at 1.8 A
To be Published
2IJQ
DownloadVisualize
BU of 2ijq by Molmil
Crystal structure of protein rrnAC1037 from Haloarcula marismortui, Pfam DUF309
Descriptor: Hypothetical protein
Authors:Malashkevich, V.N, Toro, R, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-09-30
Release date:2006-10-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of the hypothetical Protein from Haloarcula marismortui
To be Published
2O34
DownloadVisualize
BU of 2o34 by Molmil
Crystal structure of protein DVU1097 from Desulfovibrio vulgaris Hildenborough, Pfam DUF375
Descriptor: Hypothetical protein, SODIUM ION
Authors:Malashkevich, V.N, Toro, R, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-11-30
Release date:2006-12-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the Hypothetical Protein from Desulfovibrio vulgaris Hildenborough
To be Published
2P84
DownloadVisualize
BU of 2p84 by Molmil
Crystal structure of ORF041 from Bacteriophage 37
Descriptor: ORF041
Authors:Malashkevich, V.N, Toro, R, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Bain, K.T, Adams, J.M, Reyes, C, Lau, C, Gilmore, J, Rooney, I, Wasserman, T, Gheyi, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-03-21
Release date:2007-04-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the hypothetical protein from Staphylococcus phage 37
To be Published
2OX7
DownloadVisualize
BU of 2ox7 by Molmil
Crystal structure of protein EF1440 from Enterococcus faecalis
Descriptor: Hypothetical protein
Authors:Malashkevich, V.N, Toro, R, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Bain, K.T, Adams, J.M, Reyes, C, Lau, C, Gilmore, J, Rooney, I, Gheyi, T, Wasserman, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-02-19
Release date:2007-03-06
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (1.777 Å)
Cite:Crystal structure of the hypothetical protein from Enterococcus faecalis
To be Published
1XMJ
DownloadVisualize
BU of 1xmj by Molmil
Crystal structure of human deltaF508 human NBD1 domain with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
Authors:Lewis, H.A, Zhao, X, Wang, C, Sauder, J.M, Rooney, I, Noland, B.W, Lorimer, D, Kearins, M.C, Conners, K, Condon, B, Maloney, P.C, Guggino, W.B, Hunt, J.F, Emtage, S, Structural GenomiX
Deposit date:2004-10-02
Release date:2004-11-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
J.Biol.Chem., 280, 2005
1XMI
DownloadVisualize
BU of 1xmi by Molmil
Crystal structure of human F508A NBD1 domain with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
Authors:Lewis, H.A, Zhao, X, Wang, C, Sauder, J.M, Rooney, I, Noland, B.W, Lorimer, D, Kearins, M.C, Conners, K, Condon, B, Maloney, P.C, Guggino, W.B, Hunt, J.F, Emtage, S, Structural GenomiX
Deposit date:2004-10-02
Release date:2004-11-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
J.Biol.Chem., 280, 2005
3T8L
DownloadVisualize
BU of 3t8l by Molmil
Crystal Structure of adenine deaminase with Mn/Fe
Descriptor: Adenine deaminase 2, UNKNOWN ATOM OR ION
Authors:Bagaria, A, Kumaran, D, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2011-08-01
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The catalase activity of diiron adenine deaminase.
Protein Sci., 20, 2011
3DKF
DownloadVisualize
BU of 3dkf by Molmil
Structure of MET receptor tyrosine kinase in complex with inhibitor SGX-523
Descriptor: 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline, CHLORIDE ION, Hepatocyte growth factor receptor
Authors:Hendle, J.
Deposit date:2008-06-24
Release date:2009-07-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
3DKC
DownloadVisualize
BU of 3dkc by Molmil
Structure of MET receptor tyrosine kinase in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Hepatocyte growth factor receptor, ...
Authors:Hendle, J.
Deposit date:2008-06-24
Release date:2009-07-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
3DKG
DownloadVisualize
BU of 3dkg by Molmil
Structure of Mutant(Y1248L) MET receptor tyrosine kinase in complex with inhibitor SGX-523
Descriptor: 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline, CHLORIDE ION, Hepatocyte growth factor receptor
Authors:Hendle, J.
Deposit date:2008-06-24
Release date:2009-07-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
3DLS
DownloadVisualize
BU of 3dls by Molmil
Crystal structure of human PAS kinase bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PAS domain-containing serine/threonine-protein kinase
Authors:Antonysamy, S, Bonanno, J.B, Romero, R, Russell, M, Iizuka, M, Gheyi, T, Wasserman, S.R, Rutter, J, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-06-29
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
J.Biol.Chem., 285, 2010
2FH7
DownloadVisualize
BU of 2fh7 by Molmil
Crystal structure of the phosphatase domains of human PTP SIGMA
Descriptor: Receptor-type tyrosine-protein phosphatase S
Authors:Alvarado, J, Udupi, R, Smith, D, Koss, J, Wasserman, S.R, Ozyurt, S, Atwell, S, Powell, A, Kearins, M.C, Rooney, I, Maletic, M, Bain, K.T, Freeman, J.C, Russell, M, Thompson, D.A, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2005-12-23
Release date:2006-01-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural genomics of protein phosphatases.
J.STRUCT.FUNCT.GENOM., 8, 2007
2I1Y
DownloadVisualize
BU of 2i1y by Molmil
Crystal structure of the phosphatase domain of human PTP IA-2
Descriptor: GLYCEROL, Receptor-type tyrosine-protein phosphatase
Authors:Faber-Barata, J, Patskovsky, Y, Alvarado, J, Smith, D, Koss, J, Wasserman, S.R, Ozyurt, S, Atwell, S, Powell, A, Kearins, M.C, Maletic, M, Rooney, I, Bain, K.T, Freeman, M, Russell, J.C, Thompson, D.A, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-08-15
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural genomics of protein phosphatases
J.STRUCT.FUNCT.GENOM., 8, 2007
2I44
DownloadVisualize
BU of 2i44 by Molmil
Crystal structure of serine-threonine phosphatase 2C from Toxoplasma gondii
Descriptor: CALCIUM ION, Serine-threonine phosphatase 2C
Authors:Eswaramoorthy, S, Burley, S.K, Swamianthan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-08-21
Release date:2006-08-29
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
2HXP
DownloadVisualize
BU of 2hxp by Molmil
Crystal Structure of the human phosphatase (DUSP9)
Descriptor: Dual specificity protein phosphatase 9, PHOSPHATE ION
Authors:Madegowda, M, Eswaramoorthy, S, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2006-08-03
Release date:2006-08-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon