Author results

4B99
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CRYSTAL STRUCTURE OF MAPK7 (ERK5) WITH INHIBITOR
分子名称:MITOGEN-ACTIVATED PROTEIN KINASE 7, 11-cyclopentyl-2-[[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl-phenyl]amino]-5-methyl-pyrimido[4,5-b][1,4]benzodiazepin-6-one
著者Elkins, J.M., Wang, J., Vollmar, M., Mahajan, P., Savitsky, P., Deng, X., Gray, N.S., Pike, A.C.W., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2012-09-03
公開日2012-09-19
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor.
J.Med.Chem., 56, 2013
1GQ6
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PROCLAVAMINATE AMIDINO HYDROLASE FROM STREPTOMYCES CLAVULIGERUS
分子名称:PROCLAVAMINATE AMIDINO HYDROLASE, MANGANESE (II) ION
著者Elkins, J.M., Clifton, I.J., Hernandez, H., Robinson, C.V., Schofield, C.J., Hewitson, K.S.
登録日2001-11-20
公開日2002-06-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Oligomeric Structure of Proclavaminic Acid Amidino Hydrolase: Evolution of a Hydrolytic Enzyme in Clavulanic Acid Biosynthesis
Biochem.J., 366, 2002
1GQ7
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PROCLAVAMINATE AMIDINO HYDROLASE FROM STREPTOMYCES CLAVULIGERUS
分子名称:PROCLAVAMINATE AMIDINO HYDROLASE, MANGANESE (II) ION
著者Elkins, J.M., Clifton, I.J., Hernandez, H., Robinson, C.V., Schofield, C.J., Hewitson, K.S.
登録日2001-11-20
公開日2002-06-06
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
Biochem. J., 366, 2002
1GQW
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TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE FROM ESCHERICHIA COLI
分子名称:ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE, FE (II) ION, 2-AMINOETHANESULFONIC ACID, ...
著者Elkins, J.M., Ryle, M.J., Clifton, I.J., Dunning-Hotopp, J.C., Lloyd, J.S., Burzlaff, N.I., Baldwin, J.E., Hausinger, R.P., Roach, P.L.
登録日2001-12-05
公開日2002-04-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-Ray Crystal Structure of Escherichia Coli Taurine/Alpha-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates
Biochemistry, 41, 2002
1GY9
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TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE FROM ESCHERICHIA COLI
分子名称:ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE, FE (III) ION, 2-AMINOETHANESULFONIC ACID, ...
著者Elkins, J.M., Burzlaff, N.I., Ryle, M.J., Lloyd, J.S., Clifton, I.J., Baldwin, J.E., Hausinger, R.P., Roach, P.L.
登録日2002-04-22
公開日2002-04-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-Ray Crystal Structure of Escherichia Coli Taurine/Alpha-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates.
Biochemistry, 41, 2002
1H2K
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
分子名称:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ...
著者Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
登録日2002-08-12
公開日2002-11-28
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2L
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
分子名称:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ...
著者Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
登録日2002-08-12
公開日2002-11-28
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2M
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
分子名称:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ...
著者Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
登録日2002-08-12
公開日2002-11-28
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2N
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FACTOR INHIBITING HIF-1 ALPHA
分子名称:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, 2-OXOGLUTARIC ACID, ...
著者Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
登録日2002-08-12
公開日2002-11-28
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1ODM
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ANAEROBIC AC-VINYLGLYCINE FE COMPLEX)
分子名称:ISOPENICILLIN N SYNTHASE, DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VINYLGLYCINE, SULFATE ION, ...
著者Elkins, J.M., Rutledge, P.J., Burzlaff, N.I., Clifton, I.J., Adlington, R.M., Roach, P.L., Baldwin, J.E.
登録日2003-02-19
公開日2003-06-19
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue
Org.Biomol.Chem., 1, 2003
1ODN
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN-EXPOSED PRODUCT FROM ANAEROBIC AC-VINYLGLYCINE FE COMPLEX)
分子名称:ISOPENICILLIN N SYNTHASE, 6-(5-AMINO-5-CARBOXY-PENTANOYLAMINO)-3-HYDROXYMETHYL-7-OXO-4-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, SULFATE ION, ...
著者Elkins, J.M., Rutledge, P.J., Burzlaff, N.I., Clifton, I.J., Adlington, R.M., Roach, P.L., Baldwin, J.E.
登録日2003-02-19
公開日2003-06-19
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue
Org.Biomol.Chem., 1, 2003
1VZ6
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ORNITHINE ACETYLTRANSFERASE (ORF6 GENE PRODUCT - CLAVULANIC ACID BIOSYNTHESIS) FROM STREPTOMYCES CLAVULIGERUS
分子名称:ORNITHINE ACETYL-TRANSFERASE, SULFATE ION
著者Elkins, J.M., Kershaw, N.J., Schofield, C.J.
登録日2004-05-14
公開日2004-09-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献X-Ray Crystal Structure of Ornithine Acetyltransferase from the Clavulanic Acid Biosynthesis Gene Cluster.
Biochem.J., 385, 2005
1VZ7
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ORNITHINE ACETYLTRANSFERASE (ORF6 GENE PRODUCT - CLAVULANIC ACID BIOSYNTHESIS) FROM STREPTOMYCES CLAVULIGERUS
分子名称:ORNITHINE ACETYL-TRANSFERASE, SULFATE ION
著者Elkins, J.M., Kershaw, N.J., Schofield, C.J.
登録日2004-05-14
公開日2004-09-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-Ray Crystal Structure of Ornithine Acetyltransferase from the Clavulanic Acid Biosynthesis Gene Cluster.
Biochem.J., 385, 2005
1VZ8
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ORNITHINE ACETYLTRANSFERASE (ORF6 GENE PRODUCT - CLAVULANIC ACID BIOSYNTHESIS) FROM STREPTOMYCES CLAVULIGERUS (SEMET STRUCTURE)
分子名称:ORNITHINE ACETYL-TRANSFERASE, SULFATE ION
著者Elkins, J.M., Kershaw, N.J., Schofield, C.J.
登録日2004-05-14
公開日2004-09-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献X-Ray Crystal Structure of Ornithine Acetyltransferase from the Clavulanic Acid Biosynthesis Gene Cluster.
Biochem.J., 385, 2005
2BYG
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2ND PDZ DOMAIN OF DISCS LARGE HOMOLOGUE 2
分子名称:CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110
著者Elkins, J.M., Schoch, G.A., Smee, C.E.A., Berridge, G., Salah, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2005-08-01
公開日2005-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2IWN
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3RD PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
分子名称:MULTIPLE PDZ DOMAIN PROTEIN
著者Elkins, J.M., Gileadi, C., Savitsky, P., Berridge, G., Smee, C.E.A., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
登録日2006-07-03
公開日2006-07-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2IWO
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12TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
分子名称:MULTIPLE PDZ DOMAIN PROTEIN
著者Elkins, J.M., Yang, X., Gileadi, C., Schoch, G., Johansson, C., Savitsky, P., Berridge, G., Smee, C.E.A., Turnbull, A., Pike, A., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
登録日2006-07-03
公開日2006-07-26
最終更新日2012-10-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2IWP
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12TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
分子名称:MULTIPLE PDZ DOMAIN PROTEIN
著者Elkins, J.M., Yang, X., Gileadi, C., Schoch, G., Johansson, C., Savitsky, P., Berridge, G., Smee, C.E.A., Turnbull, A., Pike, A., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
登録日2006-07-03
公開日2006-07-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2IWQ
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7TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ
分子名称:MULTIPLE PDZ DOMAIN PROTEIN
著者Elkins, J.M., Berridge, G., Savitsky, P., Smee, C.E.A., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
登録日2006-07-03
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2VAC
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STRUCTURE OF N-TERMINAL ACTIN DEPOLYMERIZING FACTOR HOMOLOGY (ADF-H) DOMAIN OF HUMAN TWINFILIN-2
分子名称:TWINFILIN-2, ZINC ION, 1,2-ETHANEDIOL
著者Elkins, J.M., Pike, A.C.W., King, O., Salah, E., Savitsky, P., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Knapp, S.
登録日2007-08-30
公開日2007-10-16
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of N-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin-2
To be Published
2W0I
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STRUCTURE OF C-TERMINAL ACTIN DEPOLYMERIZING FACTOR HOMOLOGY (ADF-H) DOMAIN OF HUMAN TWINFILIN-2
分子名称:TWINFILIN-2
著者Elkins, J.M., Pike, A.C.W., Salah, E., Savitsky, P., Murray, J.W., Roos, A., von Delft, F., Edwards, A., Arrowsmith, C.H., Wikstrom, M., Bountra, C., Knapp, S.
登録日2008-08-18
公開日2008-09-30
最終更新日2017-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin- 2
To be Published
3ZON
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HUMAN TYK2 PSEUDOKINASE DOMAIN BOUND TO A KINASE INHIBITOR
分子名称:NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2, 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE
著者Elkins, J.M., Wang, J., Krojer, T., Savitsky, P., Chalk, R., Daga, N., Salah, E., Berridge, G., Picaud, S., von Delft, F., Bountra, C., Edwards, A., Knapp, S.
登録日2013-02-22
公開日2013-04-10
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Human Tyk2 Pseudokinase Domain Bound to a Kinase Inhibitor
To be Published
4AF3
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HUMAN AURORA B KINASE IN COMPLEX WITH INCENP AND VX-680
分子名称:AURORA KINASE B, INNER CENTROMERE PROTEIN, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE
著者Elkins, J.M., Vollmar, M., Wang, J., Picaud, S., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Knapp, S.
登録日2012-01-16
公開日2012-04-11
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680.
J.Med.Chem., 55, 2012
4AOT
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CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 (LOK) BOUND TO GW830263A
分子名称:Serine/threonine-protein kinase 10, CHLORIDE ION, 1-(4-{methyl[2-({4-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]amino}phenyl)-3-{3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea
著者Elkins, J.M., Salah, E., Szklarz, M., Canning, P., von Delft, F., Yue, W., Liu, Y., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2012-03-29
公開日2012-04-11
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Crystal Structure of Human Serine Threonine Kinase-10 (Lok) Bound to Gw830263A
To be Published
4APC
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CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1 (NEK1)
分子名称:SERINE/THREONINE-PROTEIN KINASE NEK1, CHLORIDE ION
著者Elkins, J.M., Hanchuk, T.D.M., Lovato, D.V., Basei, F.L., Meirelles, G.V., Kobarg, J., Szklarz, M., Vollmar, M., Mahajan, P., Rellos, P., Zhang, Y., Krojer, T., Pike, A.C.W., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2012-04-02
公開日2012-04-25
最終更新日2012-05-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of Human Nima-Related Kinase 1
To be Published