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1FQ9
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BU of 1fq9 by Molmil
CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Descriptor: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 2, ...
Authors:Schlessinger, J, Plotnikov, A.N, Ibrahimi, O.A, Eliseenkova, A.V, Yeh, B.K, Yayon, A, Linhardt, R.J, Mohammadi, M.
Deposit date:2000-09-04
Release date:2000-09-27
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Mol.Cell, 6, 2000
2FGI
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BU of 2fgi by Molmil
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Descriptor: 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA, PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1)
Authors:Mohammadi, M, Froum, S, Hamby, J.M, Schroeder, M, Panek, R.L, Lu, G.H, Eliseenkova, A.V, Green, D, Schlessinger, J, Hubbard, S.R.
Deposit date:1998-09-15
Release date:1999-09-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
EMBO J., 17, 1998
1NUN
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BU of 1nun by Molmil
Crystal Structure Analysis of the FGF10-FGFR2b Complex
Descriptor: Fibroblast growth factor-10, POLYETHYLENE GLYCOL (N=34), SULFATE ION, ...
Authors:Yeh, B.K, Igarashi, M, Eliseenkova, A.V, Plotnikov, A.N, Sher, I, Ron, D, Aaronson, S.A, Mohammadi, M.
Deposit date:2003-01-31
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Proc.Natl.Acad.Sci.USA, 100, 2003
1Q1U
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BU of 1q1u by Molmil
Crystal structure of human FHF1b (FGF12b)
Descriptor: SULFATE ION, fibroblast growth factor homologous factor 1
Authors:Olsen, S.K, Garbi, M, Zampieri, N, Eliseenkova, A.V, Ornitz, D.M, Goldfarb, M, Mohammadi, M.
Deposit date:2003-07-22
Release date:2003-08-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs
J.Biol.Chem., 278, 2003
1RY7
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BU of 1ry7 by Molmil
Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
Descriptor: Fibroblast growth factor receptor 3, Heparin-binding growth factor 1
Authors:Olsen, S.K, Ibrahimi, O.A, Raucci, A, Zhang, F, Eliseenkova, A.V, Yayon, A, Basilico, C, Linhardt, R.J, Schlessinger, J, Mohammadi, M.
Deposit date:2003-12-19
Release date:2004-02-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1IIL
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BU of 1iil by Molmil
CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor: FIBROBLAST GROWTH FACTOR RECEPTOR 2, HEPARIN-BINDING GROWTH FACTOR 2
Authors:Ibrahimi, O.A, Eliseenkova, A.V, Plotnikov, A.N, Ornitz, D.M, Mohammadi, M.
Deposit date:2001-04-23
Release date:2001-05-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
1IJT
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BU of 1ijt by Molmil
Crystal Structure of Fibroblast Growth Factor 4 (FGF4)
Descriptor: SULFATE ION, fibroblast growth factor 4
Authors:Bellosta, P, Plotnikov, A.N, Eliseenkova, A.V, Basilico, C, Mohammadi, M.
Deposit date:2001-04-29
Release date:2001-08-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.
Mol.Cell.Biol., 21, 2001
1IHK
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BU of 1ihk by Molmil
CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)
Descriptor: GLIA-ACTIVATING FACTOR, PHOSPHATE ION
Authors:Plotnikov, A.N, Eliseenkova, A.V, Ibrahimi, O.A, Lemmon, M.A, Mohammadi, M.
Deposit date:2001-04-19
Release date:2001-05-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
J.Biol.Chem., 276, 2001
1II4
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BU of 1ii4 by Molmil
CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor: FIBROBLAST GROWTH FACTOR RECEPTOR 2, HEPARIN-BINDING GROWTH FACTOR 2
Authors:Ibrahimi, O.A, Eliseenkova, A.V, Plotnikov, A.N, Ornitz, D.M, Mohammadi, M.
Deposit date:2001-04-20
Release date:2001-05-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
3HBW
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BU of 3hbw by Molmil
Crystal Structure of Human Fibroblast Growth Factor Homologous Factor 2A (FHF2A), also referred to as Fibroblast Growth Factor 13A (FGF13A)
Descriptor: Fibroblast growth factor 13
Authors:Mohammadi, M.
Deposit date:2009-05-05
Release date:2009-05-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
J.Biol.Chem., 284, 2009
2FDB
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BU of 2fdb by Molmil
Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c
Descriptor: Fibroblast growth factor receptor 2, fibroblast growth factor 8 isoform B
Authors:Mohammadi, M, Olsen, S.K.
Deposit date:2005-12-13
Release date:2006-02-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain
Genes Dev., 20, 2006
5W59
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BU of 5w59 by Molmil
Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c
Descriptor: Fibroblast growth factor 9, Fibroblast growth factor receptor 1, SULFATE ION
Authors:Mohammadi, M, Ma, J, Liu, Y.
Deposit date:2017-06-14
Release date:2017-08-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.
Structure, 25, 2017
3CLY
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BU of 3cly by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H, Mohammadi, M.
Deposit date:2008-03-20
Release date:2009-02-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:A crystallographic snapshot of tyrosine trans-phosphorylation in action
Proc.Natl.Acad.Sci.USA, 105, 2008
3OJV
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BU of 3ojv by Molmil
Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop
Descriptor: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Basic fibroblast growth factor receptor 1, Heparin-binding growth factor 1
Authors:Beenken, A, Mohammadi, M.
Deposit date:2010-08-23
Release date:2011-12-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3OJM
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BU of 3ojm by Molmil
Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation
Descriptor: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION
Authors:Beenken, A, Mohammadi, M.
Deposit date:2010-08-23
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3OJ2
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BU of 3oj2 by Molmil
Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation
Descriptor: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION
Authors:Beenken, A, Mohammadi, M.
Deposit date:2010-08-20
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3F1R
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BU of 3f1r by Molmil
Crystal structure of FGF20 dimer
Descriptor: Fibroblast growth factor 20, SULFATE ION
Authors:Kalinina, J, Mohammadi, M.
Deposit date:2008-10-28
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix
Mol.Cell.Biol., 29, 2009
2P39
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BU of 2p39 by Molmil
Crystal structure of human FGF23
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Fibroblast growth factor 23
Authors:Mohammadi, M.
Deposit date:2007-03-08
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
2P23
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BU of 2p23 by Molmil
Crystal structure of human FGF19
Descriptor: Fibroblast growth factor 19
Authors:Mohammadi, M.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
2PWL
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BU of 2pwl by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-11
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVF
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BU of 2pvf by Molmil
Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-09
Release date:2007-09-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZ5
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BU of 2pz5 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-17
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZR
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BU of 2pzr by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PSQ
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BU of 2psq by Molmil
Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain
Descriptor: Fibroblast growth factor receptor 2, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-07
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVY
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-10
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007

 

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