Author results

1FQ9
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CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, ...
Authors:Schlessinger, J., Plotnikov, A.N., Ibrahimi, O.A., Eliseenkova, A.V., Yeh, B.K., Yayon, A., Linhardt, R.J., Mohammadi, M.
Deposit date:2000-09-04
Release date:2000-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Mol.Cell, 6, 2000
1IHK
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)
Descriptor:GLIA-ACTIVATING FACTOR, PHOSPHATE ION
Authors:Plotnikov, A.N., Eliseenkova, A.V., Ibrahimi, O.A., Lemmon, M.A., Mohammadi, M.
Deposit date:2001-04-19
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
J.Biol.Chem., 276, 2001
1II4
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CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor:HEPARIN-BINDING GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 2
Authors:Ibrahimi, O.A., Eliseenkova, A.V., Plotnikov, A.N., Ornitz, D.M., Mohammadi, M.
Deposit date:2001-04-20
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
1IIL
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CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor:HEPARIN-BINDING GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 2
Authors:Ibrahimi, O.A., Eliseenkova, A.V., Plotnikov, A.N., Ornitz, D.M., Mohammadi, M.
Deposit date:2001-04-23
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
1IJT
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 4 (FGF4)
Descriptor:fibroblast growth factor 4, SULFATE ION
Authors:Bellosta, P., Plotnikov, A.N., Eliseenkova, A.V., Basilico, C., Mohammadi, M.
Deposit date:2001-04-29
Release date:2001-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.
Mol.Cell.Biol., 21, 2001
1NUN
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CRYSTAL STRUCTURE ANALYSIS OF THE FGF10-FGFR2B COMPLEX
Descriptor:Fibroblast growth factor-10, fibroblast growth factor receptor 2 isoform 2, SULFATE ION, ...
Authors:Yeh, B.K., Igarashi, M., Eliseenkova, A.V., Plotnikov, A.N., Sher, I., Ron, D., Aaronson, S.A., Mohammadi, M.
Deposit date:2003-01-31
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Proc.Natl.Acad.Sci.USA, 100, 2003
1Q1U
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CRYSTAL STRUCTURE OF HUMAN FHF1B (FGF12B)
Descriptor:fibroblast growth factor homologous factor 1, SULFATE ION
Authors:Olsen, S.K., Garbi, M., Zampieri, N., Eliseenkova, A.V., Ornitz, D.M., Goldfarb, M., Mohammadi, M.
Deposit date:2003-07-22
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs
J.Biol.Chem., 278, 2003
1RY7
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CRYSTAL STRUCTURE OF THE 3 IG FORM OF FGFR3C IN COMPLEX WITH FGF1
Descriptor:Heparin-binding growth factor 1, Fibroblast growth factor receptor 3
Authors:Olsen, S.K., Ibrahimi, O.A., Raucci, A., Zhang, F., Eliseenkova, A.V., Yayon, A., Basilico, C., Linhardt, R.J., Schlessinger, J., Mohammadi, M.
Deposit date:2003-12-19
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proc.Natl.Acad.Sci.Usa, 101, 2004
2FGI
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1), 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA
Authors:Mohammadi, M., Froum, S., Hamby, J.M., Schroeder, M., Panek, R.L., Lu, G.H., Eliseenkova, A.V., Green, D., Schlessinger, J., Hubbard, S.R.
Deposit date:1998-09-15
Release date:1999-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
EMBO J., 17, 1998
2FDB
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR (FGF)8B IN COMPLEX WITH FGF RECEPTOR (FGFR) 2C
Descriptor:fibroblast growth factor 8 isoform B, Fibroblast growth factor receptor 2
Authors:Mohammadi, M., Olsen, S.K.
Deposit date:2005-12-13
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain
Genes Dev., 20, 2006
2P23
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CRYSTAL STRUCTURE OF HUMAN FGF19
Descriptor:Fibroblast growth factor 19
Authors:Mohammadi, M.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
2P39
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CRYSTAL STRUCTURE OF HUMAN FGF23
Descriptor:Fibroblast growth factor 23, SUCROSE OCTASULFATE
Authors:Mohammadi, M.
Deposit date:2007-03-08
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
2PSQ
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CRYSTAL STRUCTURE OF UNPHOSPHORYLATED UNACTIVATED WILD TYPE FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-07
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVF
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CRYSTAL STRUCTURE OF TYROSINE PHOSPHORYLATED ACTIVATED FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN IN COMPLEX WITH ATP ANALOG AND SUBSTRATE PEPTIDE
Descriptor:Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-09
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVY
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K659N MUTATION RESPONSIBLE FOR AN UNCLASSIFIED CRANIOSYNOSTOSIS SYNDROME.
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-10
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PWL
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549H MUTATION RESPONSIBLE FOR CROUZON SYNDROME.
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-11
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PY3
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC E565G MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, MAGNESIUM ION, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-15
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZ5
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549T MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, MAGNESIUM ION, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-17
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZP
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K526E MUTATION RESPONSIBLE FOR CROUZON SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, MAGNESIUM ION, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZR
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K641R MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2Q0B
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC E565A MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-21
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
3CLY
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAINS TRAPPED IN TRANS-PHOSPHORYLATION REACTION
Descriptor:Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2008-03-20
Release date:2009-02-03
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:A crystallographic snapshot of tyrosine trans-phosphorylation in action
Proc.Natl.Acad.Sci.USA, 105, 2008
3F1R
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CRYSTAL STRUCTURE OF FGF20 DIMER
Descriptor:Fibroblast growth factor 20, SULFATE ION
Authors:Kalinina, J., Mohammadi, M.
Deposit date:2008-10-28
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix
Mol.Cell.Biol., 29, 2009
3HBW
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CRYSTAL STRUCTURE OF HUMAN FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 2A (FHF2A), ALSO REFERRED TO AS FIBROBLAST GROWTH FACTOR 13A (FGF13A)
Descriptor:Fibroblast growth factor 13
Authors:Mohammadi, M.
Deposit date:2009-05-05
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
J.Biol.Chem., 284, 2009
3OJ2
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CRYSTAL STRUCTURE OF FGF1 COMPLEXED WITH THE ECTODOMAIN OF FGFR2B HARBORING THE A172F PFEIFFER SYNDROME MUTATION
Descriptor:Heparin-binding growth factor 1, Fibroblast growth factor receptor 2, SULFATE ION
Authors:Beenken, A., Mohammadi, M.
Deposit date:2010-08-20
Release date:2011-08-31
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
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