Author results

1AE4
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ALDEHYDE REDUCTASE COMPLEXED WITH COFACTOR AND INHIBITOR, ALPHA CARBON ATOMS ONLY
Descriptor:ALDEHYDE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT
Authors:El-Kabbani, O.
Deposit date:1997-03-05
Release date:1998-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Studies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complex.
Proteins, 29, 1997
1BIO
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HUMAN COMPLEMENT FACTOR D IN COMPLEX WITH ISATOIC ANHYDRIDE INHIBITOR
Descriptor:COMPLEMENT FACTOR D, ISATOIC ANHYDRIDE, GLYCEROL
Authors:Jing, H., Babu, Y.S., Moore, D., Kilpatrick, J.M., Liu, X.-Y., Volanakis, J.E., Narayana, S.V.L.
Deposit date:1998-06-18
Release date:1999-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
J.Mol.Biol., 282, 1998
1C3I
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HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Steele, D.L., Kammlott, R.U., Crowther, R.L., Birktoft, J.J., Dunten, P., Engler, J.E.
Deposit date:1999-07-27
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13, 2000
1C8T
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HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Steele, D.L., el-Kabbani, O., Dunten, P., Crowther, R.L.
Deposit date:1999-07-29
Release date:2000-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13, 2000
1CWN
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CRYSTAL STRUCTURE OF PORCINE ALDEHYDE REDUCTASE HOLOENZYME
Descriptor:ALDEHYDE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O.
Deposit date:1996-07-30
Release date:1998-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of porcine aldehyde reductase at 2.0 angstrom resolution: Modeling an inhibitor in the active site of the enzyme.
Protein Pept.Lett., 3, 1996
1DST
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MUTANT OF FACTOR D WITH ENHANCED CATALYTIC ACTIVITY
Descriptor:FACTOR D
Authors:Narayana, S.V.L., Volanakis, J.E.
Deposit date:1995-09-13
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a complement factor D mutant expressing enhanced catalytic activity.
J.Biol.Chem., 270, 1995
1DSU
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HUMAN FACTOR D, COMPLEMENT ACTIVATING ENZYME
Descriptor:FACTOR D
Authors:Narayana, S.V.L., Volanakis, J.E., Delucas, L.J.
Deposit date:1995-09-15
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of human factor D. A complement system protein at 2.0 A resolution.
J.Mol.Biol., 235, 1994
1FDP
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PROENZYME OF HUMAN COMPLEMENT FACTOR D, RECOMBINANT PROFACTOR D
Descriptor:PROENZYME OF COMPLEMENT FACTOR D
Authors:Jing, H., Macon, K.J., Moore, D., Delucas, L.J., Volanakis, J.E., Narayana, S.V.L.
Deposit date:1998-12-03
Release date:1999-12-03
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D.
Embo J., 18, 1999
1HFD
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HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM
Descriptor:COMPLEMENT FACTOR D
Authors:Jing, H., Babu, Y.S., Moore, D., Kilpatrick, J.M., Liu, X.-Y., Volanakis, J.E., Narayana, S.V.L.
Deposit date:1998-06-18
Release date:1999-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
J.Mol.Biol., 282, 1998
1PR9
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HUMAN L-XYLULOSE REDUCTASE HOLOENZYME
Descriptor:L-XYLULOSE REDUCTASE, POTASSIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Ishikura, S., Darmanin, C., Carbone, V., Chung, R.P.-T., Usami, N., Hara, A.
Deposit date:2003-06-20
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis
Proteins, 55, 2004
1PWL
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND MINALRESTAT
Descriptor:aldose reductase, 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O., Darmanin, C., Schneider, T.R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A., Podjarny, A.
Deposit date:2003-07-02
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
1PWM
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND FIDARESTAT
Descriptor:aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Darmanin, C., Schneider, T.R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A., Podjarny, A.
Deposit date:2003-07-02
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
1WNT
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STRUCUTRE OF THE TETRAMERIC FORM OF HUMAN L-XYLULOSE REDUCTASE
Descriptor:L-xylulose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O., Carbone, V., Darmanin, C., Ishikura, S., Hara, A.
Deposit date:2004-08-09
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis
Proteins, 60, 2005
1X96
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE WITH CITRATES BOUND IN THE ACTIVE SITE
Descriptor:aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004
1X97
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH 2R4S (STEREOISOMER OF FIDARESTAT, 2S4S)
Descriptor:Aldose Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004
1X98
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH 2S4R (STEREOISOMER OF FIDARESTAT, 2S4S)
Descriptor:Aldose Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ...
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004
2AGT
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ALDOSE REDUCTASE MUTANT LEU 300 PRO COMPLEXED WITH FIDARESTAT
Descriptor:Aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Petrova, T., Steuber, H., Hazemann, I., Cousido-Siah, A., Mitschler, A., Chung, R., Oka, M., Klebe, G., El-Kabbani, O., Joachimiak, A., Podjarny, A.
Deposit date:2005-07-27
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro-Fidarestat Complex
J.Med.Chem., 48, 2005
2ALR
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ALDEHYDE REDUCTASE
Descriptor:ALDEHYDE REDUCTASE
Authors:El-Kabbani, O.
Deposit date:1994-09-06
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
Acta Crystallogr.,Sect.D, 50, 1994
2O48
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CRYSTAL STRUCTURE OF MAMMALIAN DIMERIC DIHYDRODIOL DEHYDROGENASE
Descriptor:Dimeric dihydrodiol dehydrogenase, SULFATE ION, P-HYDROXYACETOPHENONE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2006-12-04
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis.
Proteins, 70, 2008
2O4U
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CRYSTAL STRUCTURE OF MAMMALIAN DIMERIC DIHYDRODIOL DEHYDROGENASE
Descriptor:Dimeric dihydrodiol dehydrogenase, PHOSPHATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2006-12-04
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis.
Proteins, 70, 2008
2OKJ
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THE X-RAY CRYSTAL STRUCTURE OF THE 67KDA ISOFORM OF GLUTAMIC ACID DECARBOXYLASE (GAD67)
Descriptor:Glutamate decarboxylase 1, GAMMA-AMINO-BUTANOIC ACID, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID
Authors:Buckle, A.M., Fenalti, G., Law, R.H.P., Whisstock, J.C.
Deposit date:2007-01-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14, 2007
2OKK
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THE X-RAY CRYSTAL STRUCTURE OF THE 65KDA ISOFORM OF GLUTAMIC ACID DECARBOXYLASE (GAD65)
Descriptor:Glutamate decarboxylase 2, GAMMA-AMINO-BUTANOIC ACID, GLYCEROL
Authors:Buckle, A.M., Fenalti, G., Law, R.H.P., Whisstock, J.C.
Deposit date:2007-01-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14, 2007
2P5N
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CRYSTAL STRUCTURE OF MOUSE 17-ALPHA HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH COENZYME NADPH
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Dhagat, U.
Deposit date:2007-03-15
Release date:2007-10-09
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Acta Crystallogr.,Sect.F, 63, 2007
2POQ
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DIMERIC DIHYDRODIOL DEHYDROGENASE COMPLEXED WITH INHIBITOR, ISOASCORBIC ACID
Descriptor:Dimeric dihydrodiol dehydrogenase, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2007-04-27
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.
Acta Crystallogr.,Sect.D, 64, 2008
2PZN
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THE CRYSTALLOGRAPHIC STRUCTURE OF ALDOSE REDUCTASE IDD393 COMPLEX CONFIRMS LEU300 AS A SPECIFICITY DETERMINANT
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID
Authors:Ruiz, F., Hazemann, I., Darmanin, C., Mitschler, A., Van Zandt, M., Joachimiak, A., El-Kabbani, O., Podjarny, A.
Deposit date:2007-05-18
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:The Crystallographic Structure of Alr2-Idd393 Complex Confirms Leu300 as a Specificity Determinant
To be Published
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