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4UF6
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BU of 4uf6 by Molmil
UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G
Descriptor: NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, POLYUBIQUITIN-B, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-23
Release date:2015-03-04
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
4UEL
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BU of 4uel by Molmil
UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain
Descriptor: POLYUBIQUITIN-B, PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-18
Release date:2015-03-04
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
4UF5
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BU of 4uf5 by Molmil
Crystal structure of UCH-L5 in complex with inhibitory fragment of INO80G
Descriptor: NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-23
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
4UEM
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BU of 4uem by Molmil
UCH-L5 in complex with the RPN13 DEUBAD domain
Descriptor: PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5
Authors:Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K.
Deposit date:2014-12-18
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57, 2015
5LRV
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BU of 5lrv by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin
Descriptor: GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ...
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRW
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BU of 5lrw by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin
Descriptor: GLYCEROL, OTU domain-containing protein 7B, Polyubiquitin-B
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRX
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BU of 5lrx by Molmil
Structure of A20 OTU domain bound to ubiquitin
Descriptor: Polyubiquitin-B, Tumor necrosis factor alpha-induced protein 3
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRU
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BU of 5lru by Molmil
Structure of Cezanne/OTUD7B OTU domain
Descriptor: OTU domain-containing protein 7B
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
4BOS
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BU of 4bos by Molmil
Structure of OTUD2 OTU domain in complex with Ubiquitin K11-linked peptide
Descriptor: MAGNESIUM ION, NITRATE ION, OTUD2, ...
Authors:Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2013-05-22
Release date:2013-07-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOP
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BU of 4bop by Molmil
Structure of OTUD1 OTU domain
Descriptor: OTU DOMAIN-CONTAINING PROTEIN 1, PHOSPHATE ION
Authors:Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOU
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BU of 4bou by Molmil
Structure of OTUD3 OTU domain
Descriptor: OTU DOMAIN-CONTAINING PROTEIN 3
Authors:Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOQ
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BU of 4boq by Molmil
Structure of OTUD2 OTU domain
Descriptor: GLYCEROL, UBIQUITIN THIOESTERASE OTU1
Authors:Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOZ
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BU of 4boz by Molmil
Structure of OTUD2 OTU domain in complex with K11-linked di ubiquitin
Descriptor: GLYCEROL, UBIQUITIN THIOESTERASE OTU1, UBIQUITIN-C
Authors:Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
6WUU
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BU of 6wuu by Molmil
Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR250
Descriptor: MAGNESIUM ION, Non-structural protein 3, VIR250, ...
Authors:Lv, Z, Olsen, S.K.
Deposit date:2020-05-05
Release date:2020-05-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Sci Adv, 6, 2020
6WX4
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BU of 6wx4 by Molmil
Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR251
Descriptor: Non-structural protein 3, VIR251, ZINC ION
Authors:Lv, Z, Olsen, S.K.
Deposit date:2020-05-09
Release date:2020-05-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.655 Å)
Cite:Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Sci Adv, 6, 2020
7SOL
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BU of 7sol by Molmil
Crystal Structures of the bispecific ubiquitin/FAT10 activating enzyme, Uba6
Descriptor: ADENOSINE MONOPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Ubiquitin, ...
Authors:Olsen, S.K, Gao, F, Lv, Z.
Deposit date:2021-10-31
Release date:2022-11-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.25000644 Å)
Cite:Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
Nat Commun, 13, 2022
6R8F
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BU of 6r8f by Molmil
Cryo-EM structure of the Human BRISC-SHMT2 complex
Descriptor: BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2), BRISC complex subunit Abraxas 2, ...
Authors:Walden, M, Hesketh, E, Tian, L, Ranson, N.A, Greenberg, R.A, Zeqiraj, E.
Deposit date:2019-04-01
Release date:2019-06-05
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.
Nature, 570, 2019
5IFR
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BU of 5ifr by Molmil
Structure of the stable UBE2D3-UbDha conjugate
Descriptor: GLYCEROL, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D3
Authors:Pruneda, J.N, Mulder, M.P.C, Witting, K, Ovaa, H, Komander, D.
Deposit date:2016-02-26
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Nat.Chem.Biol., 12, 2016
6SAK
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BU of 6sak by Molmil
Structure of the OTULINcat C129A - SNX27 PDZ domain complex.
Descriptor: GLYCEROL, SULFATE ION, Sorting nexin-27, ...
Authors:Elliott, P.R, Komander, D.
Deposit date:2019-07-17
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Regulation of the endosomal SNX27-retromer by OTULIN.
Nat Commun, 10, 2019
5OE7
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BU of 5oe7 by Molmil
Structure of OTULIN bound to the Met1-linked diubiquitin activity probe
Descriptor: Polyubiquitin-C, Ubiquitin thioesterase otulin
Authors:Elliott, P.R, Komander, D.
Deposit date:2017-07-07
Release date:2017-09-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.
Cell Chem Biol, 24, 2017

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PDB entries from 2024-03-27

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