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Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.
Descriptor:	3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE, Hepatitis C virus NS5B RNA polymerase
Authors:	Love, R.A, Parge, H.E, Yu, X, Hickey, M.J, Diehl, W, Gao, J, Wriggers, H, Ekker, A, Wang, L, Thomson, J.A, Dragovich, P.S, Fuhrman, S.A.
Deposit date:	2003-03-18
Release date:	2004-03-18
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J.Virol., 77, 2003

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
Descriptor:	4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol, Heat shock protein HSP 90-alpha, PHOSPHATE ION
Authors:	Gajiwala, K.S.
Deposit date:	2008-09-19
Release date:	2008-11-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. Bioorg.Med.Chem.Lett., 18, 2008

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
Descriptor:	2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol, Heat shock protein HSP 90-alpha, PHOSPHATE ION
Authors:	Gajiwala, K.S.
Deposit date:	2008-09-19
Release date:	2008-11-25
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. Bioorg.Med.Chem.Lett., 18, 2008