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2X72
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CRYSTAL STRUCTURE OF THE CONSTITUTIVELY ACTIVE E113Q,D2C,D282C RHODOPSIN MUTANT WITH BOUND GALPHACT PEPTIDE.
Descriptor:RHODOPSIN, GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-1, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Standfuss, J., Edwards, P.C., Dantona, A., Fransen, M., Xie, G., Oprian, D.D., Schertler, G.F.X.
Deposit date:2010-02-22
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structural Basis of Agonist Induced Activation in Constitutively Active Rhodopsin
Nature, 471, 2011
2Y00
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y01
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102)
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-03-30
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y02
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST CARMOTEROL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y03
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y04
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
1TQQ
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STRUCTURE OF TOLC IN COMPLEX WITH HEXAMMINECOBALT
Descriptor:Outer membrane protein tolC, COBALT HEXAMMINE(III)
Authors:Higgins, M.K., Eswaran, J., Edwards, P.C., Schertler, G.F., Hughes, C., Koronakis, V.
Deposit date:2004-06-18
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug effllux protein TolC
J.Mol.Biol., 342, 2004
2J4Y
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CRYSTAL STRUCTURE OF A RHODOPSIN STABILIZING MUTANT EXPRESSED IN MAMMALIAN CELLS
Descriptor:RHODOPSIN, RETINAL, N-ACETYL-D-GLUCOSAMINE
Authors:Standfuss, J., Xie, G., Edwards, P.C., Burghammer, M., Oprian, D.D., Schertler, G.F.X.
Deposit date:2006-09-07
Release date:2007-09-25
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal Structure of a Thermally Stable Rhodopsin Mutant.
J.Mol.Biol., 372, 2007
2JIC
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HIGH RESOLUTION STRUCTURE OF XYLANASE-II FROM ONE MICRON BEAM EXPERIMENT
Descriptor:XYLANASE-II
Authors:Moukhametzianov, R., Burghammer, M., Edwards, P.C., Petitdemange, S., Popov, D., Fransen, M., Schertler, G.F., Riekel, C.
Deposit date:2007-02-27
Release date:2008-05-13
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Protein Crystallography with a Micrometre-Sized Synchrotron-Radiation Beam.
Acta Crystallogr.,Sect.D, 64, 2008
2R4R
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR
Descriptor:Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, light chain, ...
Authors:Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K.
Deposit date:2007-08-31
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2R4S
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR
Descriptor:Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, light chain, ...
Authors:Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K.
Deposit date:2007-08-31
Release date:2007-11-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2VT4
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL
Descriptor:BETA1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, SODIUM ION, ...
Authors:Warne, A., Serrano-Vega, M.J., Baker, J.G., Moukhametzianov, R., Edwards, P.C., Henderson, R., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2008-05-09
Release date:2008-06-24
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a Beta1-Adrenergic G-Protein-Coupled Receptor.
Nature, 454, 2008
2YCW
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, HEGA-10, ...
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCX
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCY
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL, ...
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCZ
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3-iodo-1H-indole-2-carbonitrile, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Moukhametzianov, R., Warne, T., Edwards, P.C., Serrano-Vega, M.J., Leslie, A.G.W., Tate, C.G., Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YDO
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH ADENOSINE BOUND
Descriptor:ADENOSINE RECEPTOR A2A, ADENOSINE, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Lebon, G., Warne, T., Edwards, P.C., Bennett, K., Langmead, C.J., Leslie, A.G.W., Tate, C.G.
Deposit date:2011-03-23
Release date:2011-05-18
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
2YDV
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH NECA BOUND
Descriptor:ADENOSINE RECEPTOR A2A, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Lebon, G., Warne, T., Edwards, P.C., Bennett, K., Langmead, C.J., Leslie, A.G.W., Tate, C.G.
Deposit date:2011-03-24
Release date:2011-05-18
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
3J7Y
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STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM HUMAN MITOCHONDRIA
Descriptor:16S rRNA, mt-tRNAVal, uL2, ...
Authors:Brown, A., Amunts, A., Bai, X.C., Sugimoto, Y., Edwards, P.C., Murshudov, G., Scheres, S.H.W., Ramakrishnan, V.
Deposit date:2014-08-26
Release date:2014-10-15
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the large ribosomal subunit from human mitochondria.
Science, 346, 2014
4AMI
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND BIASED AGONIST BUCINDOLOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, 2-[(2S)-3-[[1-(1H-indol-3-yl)-2-methyl-propan-2-yl]amino]-2-oxidanyl-propoxy]benzenecarbonitrile, HEGA-10
Authors:Warne, T., Edwards, P.C., Leslie, A.G., Tate, C.G.
Deposit date:2012-03-11
Release date:2012-05-23
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Structure, 20, 2012
4AMJ
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND BIASED AGONIST CARVEDILOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, (2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL, SODIUM ION, ...
Authors:Warne, T., Edwards, P.C., Leslie, A.G., Tate, C.G.
Deposit date:2012-03-12
Release date:2012-05-23
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Structure, 20, 2012
4BVN
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ULTRA-THERMOSTABLE BETA1-ADRENOCEPTOR WITH CYANOPINDOLOL BOUND
Descriptor:BETA-1 ADRENERGIC RECEPTOR, SODIUM ION, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, ...
Authors:Miller, J., Nehme, R., Warne, T., Edwards, P.C., Leslie, A.G.W., Schertler, G., Tate, C.G.
Deposit date:2013-06-26
Release date:2014-04-02
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The 2.1 A Resolution Structure of Cyanopindolol-Bound Beta1- Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor.
Plos One, 9, 2014
4UG2
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH CGS21680 BOUND
Descriptor:THERMOSTABILISED HUMAN A2A RECEPTOR, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE
Authors:Lebon, G., Edwards, P.C., Leslie, A.G.W., Tate, C.G.
Deposit date:2015-03-21
Release date:2015-04-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
4UHR
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH CGS21680 BOUND
Descriptor:THERMOSTABILISED HUMAN A2A RECEPTOR, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE
Authors:Lebon, G., Edwards, P.C., Leslie, A.G.W., Tate, C.G.
Deposit date:2015-03-25
Release date:2015-04-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
6FUF
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CRYSTAL STRUCTURE OF THE RHODOPSIN-MINI-GO COMPLEX
Descriptor:Rhodopsin, Guanine nucleotide-binding protein G(o) subunit alpha, RETINAL, ...
Authors:Tsai, C.-J., Weinert, T., Muehle, J., Pamula, F., Nehme, R., Flock, T., Nogly, P., Edwards, P.C., Carpenter, B., Gruhl, T., Ma, P., Deupi, X., Standfuss, J., Tate, C.G., Schertler, G.F.X.
Deposit date:2018-02-27
Release date:2018-10-03
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (3.117 Å)
Cite:Crystal structure of rhodopsin in complex with a mini-Gosheds light on the principles of G protein selectivity.
Sci Adv, 4, 2018
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