Author results

2HOJ
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CRYSTAL STRUCTURE OF AN E. COLI THI-BOX RIBOSWITCH BOUND TO THIAMINE PYROPHOSPHATE, MANGANESE IONS
Descriptor:thi-box riboswitch, MANGANESE (II) ION, MAGNESIUM ION, ...
Authors:Edwards, T.E., Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOK
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CRYSTAL STRUCTURE OF AN E. COLI THI-BOX RIBOSWITCH BOUND TO THIAMINE PYROPHOSPHATE, CALCIUM IONS
Descriptor:thi-box riboswitch, CALCIUM ION, THIAMINE DIPHOSPHATE
Authors:Edwards, T.E., Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOL
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CRYSTAL STRUCTURE OF AN E. COLI THI-BOX RIBOSWITCH BOUND TO THIAMINE PYROPHOSPHATE, BARIUM IONS
Descriptor:thi-box riboswitch, BARIUM ION, CALCIUM ION, ...
Authors:Edwards, T.E., Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOM
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CRYSTAL STRUCTURE OF AN E. COLI THI-BOX RIBOSWITCH BOUND TO THIAMINE MONOPHOSPHATE
Descriptor:thi-box riboswitch, MAGNESIUM ION, CALCIUM ION, ...
Authors:Edwards, T.E., Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOO
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CRYSTAL STRUCTURE OF AN E. COLI THI-BOX RIBOSWITCH BOUND TO BENFOTIAMINE
Descriptor:thi-box riboswitch, CALCIUM ION, S-BENZOYLTHIAMINE O-MONOPHOSPHATE
Authors:Edwards, T.E., Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOP
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CRYSTAL STRUCTURE OF AN E. COLI THI-BOX RIBOSWITCH BOUND TO PYRITHIAMINE
Descriptor:thi-box riboswitch, MAGNESIUM ION, CALCIUM ION, ...
Authors:Edwards, T.E., Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
3IEF
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CRYSTAL STRUCTURE OF TRNA GUANINE-N1-METHYLTRANSFERASE FROM BARTONELLA HENSELAE USING MPCS.
Descriptor:tRNA (guanine-N(1)-)-methyltransferase
Authors:Edwards, T.E., Stahl, G., Gerdts, C.J., Staker, B.L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-07-22
Release date:2009-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of tRNA guanine-n1-methyltransferase from Bartonella henselae using MPCS.
To be Published
3OT0
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CRYSTAL STRUCTURE OF A DNA CONTAINING THE RIGID NITROXIDE SPIN-LABELED NUCLEOTIDE C-SPIN
Descriptor:Spin-labeled DNA
Authors:Edwards, T.E.
Deposit date:2010-09-10
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7004 Å)
Cite:Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe C.
Nucleic Acids Res., 10, 2011
3TE8
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CRYSTAL STRUCTURE OF RISS PERIPLASMIC DOMAIN AT LOW PH DIMER WITH N-TERMINI ORDERED
Descriptor:Sensor histidine kinase RisS
Authors:Edwards, T.E., Abendroth, J., Labiuk, S.L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-08-12
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of risS periplasmic domain at low pH dimer with N-termini ordered
To be Published
5TQJ
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CRYSTAL STRUCTURE OF RESPONSE REGULATOR RECEIVER PROTEIN FROM BURKHOLDERIA PHYMATUM
Descriptor:Response regulator receiver protein, CHLORIDE ION, 1,2-ETHANEDIOL
Authors:Edwards, T.E., Dranow, D.M., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-10-24
Release date:2016-11-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of response regulator receiver protein from Burkholderia phymatum
To Be Published
6AMZ
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CRYSTAL STRUCTURE OF A DOMAIN SWAPPED 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATE N-SUCCINYLTRANSFERASE FROM ACINETOBACTER BAUMANNII
Descriptor:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, (4R)-2-METHYLPENTANE-2,4-DIOL, CALCIUM ION
Authors:Edwards, T.E., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-08-11
Release date:2017-08-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a domain swapped 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Acinetobacter baumannii
To Be Published
6AQ3
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CRYSTAL STRUCTURE OF A TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3 FROM NAEGLERIA FOWLERI COVALENTLY BOUND TO PALMITIC ACID
Descriptor:trafficking protein particle complex subunit 3, PALMITIC ACID, 1,2-ETHANEDIOL
Authors:Edwards, T.E., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-08-18
Release date:2017-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a trafficking protein particle complex subunit 3 from Naegleria fowleri covalently bound to palmitic acid
To Be Published
6AY1
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CRYSTAL STRUCTURE OF A NUCLEOSIDE DIPHOSPHATE KINASE NDK FROM HELICOBACTER PYLORI
Descriptor:Nucleoside diphosphate kinase, ISOPROPYL ALCOHOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Edwards, T.E., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-09-07
Release date:2017-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a nucleoside diphosphate kinase NDK from Helicobacter pylori
To be Published
3IFT
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CRYSTAL STRUCTURE OF GLYCINE CLEAVAGE SYSTEM PROTEIN H FROM MYCOBACTERIUM TUBERCULOSIS, USING X-RAYS FROM THE COMPACT LIGHT SOURCE.
Descriptor:Glycine cleavage system H protein
Authors:Edwards, T.E., Abendroth, J., Staker, B., Mayer, C., Phan, I., Kelley, A., Analau, E., Leibly, D., Rifkin, J., Loewen, R., Ruth, R.D., Stewart, L.J., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2009-07-25
Release date:2009-08-11
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source.
J.Struct.Funct.Genom., 11, 2010
4E76
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APO CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH BETA HAIRPIN LOOP DELETION
Descriptor:RNA-directed RNA polymerase, SULFATE ION, 1,2-ETHANEDIOL
Authors:Edwards, T.E., Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E78
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CRYSTAL STRUCTURE OF A PRODUCT STATE ASSEMBLY OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH BETA HAIRPIN LOOP DELETION BOUND TO PRIMER-TEMPLATE RNA WITH 3'-DG
Descriptor:5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase)
Authors:Edwards, T.E., Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E7A
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CRYSTAL STRUCTURE OF A PRODUCT STATE ASSEMBLY OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH BETA HAIRPIN DELETION BOUND TO PRIMER-TEMPLATE RNA WITH A 2',3'-DDC
Descriptor:5'-R(*CP*AP*UP*GP*GP*C)-D(P*(DOC))-3', RNA-directed RNA polymerase
Authors:Edwards, T.E., Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4EYE
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CRYSTAL STRUCTURE OF A PROBABLE OXIDOREDUCTASE FROM MYCOBACTERIUM ABSCESSUS SOLVED BY IODIDE ION SAD
Descriptor:Probable oxidoreductase, (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION
Authors:Edwards, T.E., Abendroth, J., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-05-01
Release date:2012-05-09
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
4OBC
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CRYSTAL STRUCTURE OF HCV POLYMERASE NS5B GENOTYPE 2A JFH-1 ISOLATE WITH THE S15G, C223H, V321I RESISTANCE MUTATIONS AGAINST THE GUANOSINE ANALOG GS-0938 (PSI-3529238)
Descriptor:RNA-directed RNA polymerase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Edwards, T.E., Abendroth, J., Appleby, T.C.
Deposit date:2014-01-07
Release date:2014-09-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance.
Antimicrob.Agents Chemother., 58, 2014
4OGX
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CRYSTAL STRUCTURE OF FAB DX-2930 IN COMPLEX WITH HUMAN PLASMA KALLIKREIN AT 2.4 ANGSTROM RESOLUTION
Descriptor:Plasma kallikrein, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ...
Authors:Edwards, T.E., Clifton, M.C., Abendroth, J., Nixon, A., Ladner, R.
Deposit date:2014-01-16
Release date:2014-07-09
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
4OGY
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CRYSTAL STRUCTURE OF FAB DX-2930 IN COMPLEX WITH HUMAN PLASMA KALLIKREIN AT 2.1 ANGSTROM RESOLUTION
Descriptor:Plasma kallikrein, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ...
Authors:Edwards, T.E., Clifton, M.C., Abendroth, J., Nixon, A., Ladner, R.
Deposit date:2014-01-16
Release date:2014-07-09
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
4WT9
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APO CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH E86Q E87Q S15G C223H V321I AND DELTA8 MUTATIONS
Descriptor:RNA-directed RNA polymerase, CHLORIDE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Edwards, T.E., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTA
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH UDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor:RNA PRIMER TEMPLATE CAAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTC
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH CDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AGAAAUUU
Descriptor:RNA PRIMER TEMPLATE AGAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTD
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CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
Descriptor:RNA PRIMER TEMPLATE AUAAAUUU, RNA-directed RNA polymerase, MANGANESE (II) ION, ...
Authors:Edwards, T.E., Fox III, D., Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015