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1Q7F
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BU of 1q7f by Molmil
Brain Tumor NHL domain
Descriptor: brain tumor CG10719-PA
Authors:Edwards, T.A, Wilkinson, B.D, Wharton, R.P, Aggarwal, A.K.
Deposit date:2003-08-18
Release date:2003-10-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Model of the Brain Tumor-Pumilio translation repressor complex
Genes Dev., 17, 2003
3H3D
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BU of 3h3d by Molmil
Drosophila Pumilio RNA binding domain (Puf domain)
Descriptor: Maternal protein pumilio
Authors:Edwards, T.A, Aggarwal, A.K, Wharton, R.P.
Deposit date:2009-04-16
Release date:2009-04-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Pumilio reveals similarity between RNA and peptide binding motifs.
Cell(Cambridge,Mass.), 105, 2001
2FE9
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BU of 2fe9 by Molmil
Solution structure of the Vts1 SAM domain in the presence of RNA
Descriptor: Protein VTS1
Authors:Edwards, T.A, Butterwick, J.A, Palmer, A.G, Aggarwal, A.K.
Deposit date:2005-12-15
Release date:2006-01-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution Structure of the Vts1 SAM Domain in the Presence of RNA.
J.Mol.Biol., 356, 2006
6G0Y
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BU of 6g0y by Molmil
X-ray structure of M-21 protein complex
Descriptor: Matrix M2-1, Phosphoprotein, ZINC ION
Authors:Edwards, T.A, Barr, J.
Deposit date:2018-03-20
Release date:2018-11-14
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.
Mbio, 9, 2018
6YR8
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BU of 6yr8 by Molmil
Affimer K6 - KRAS protein complex
Descriptor: Affimer K6, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2020-04-19
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
6YXW
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BU of 6yxw by Molmil
Affimer K3 - KRAS protein complex
Descriptor: Affimer K3, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2020-05-04
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
6YSI
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BU of 6ysi by Molmil
Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A.
Deposit date:2020-04-22
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
6Z0O
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BU of 6z0o by Molmil
Structure of Affimer-NP bound to Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein
Descriptor: Affimer-NP, Nucleocapsid
Authors:Alvarez-Rodriguez, B, Tiede, C, Trinh, C, Tomlinson, D, Edwards, T.A, Barr, J.N.
Deposit date:2020-05-10
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5974 Å)
Cite:Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.
Plos Negl Trop Dis, 14, 2020
7A00
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BU of 7a00 by Molmil
Crystal structure of Shank1 PDZ in complex with L6F mutant of the C-terminal hexapeptide from GKAP
Descriptor: L6F mutant of C-terminal hexapeptide from Guanylate kinase-associated protein, SH3 and multiple ankyrin repeat domains protein 1
Authors:Zsofia, H, Hetherington, K, Fruzsina, H, Edwards, T.A, Wilson, A.J.
Deposit date:2020-08-05
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Query-guided protein-protein interaction inhibitor discovery.
Chem Sci, 12, 2021
6HJL
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BU of 6hjl by Molmil
Affimer:BclxL
Descriptor: Affimer ADB13, Bcl-2-like protein 1
Authors:Miles, J.A, Trinh, C.H, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2018-09-04
Release date:2020-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Biorxiv, 2020
7QGS
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BU of 7qgs by Molmil
Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid)
Descriptor: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION
Authors:Hegedus, Z, Wilson, A.J, Edwards, T.A.
Deposit date:2021-12-10
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Understanding p300-transcription factor interactions using sequence variation and hybridization.
Rsc Chem Biol, 3, 2022
6YHS
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BU of 6yhs by Molmil
Acinetobacter baumannii ribosome-amikacin complex - 50S subunit
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A.
Deposit date:2020-03-30
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
6YPU
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BU of 6ypu by Molmil
Acinetobacter baumannii ribosome-amikacin complex - 30S subunit body
Descriptor: (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 16S ribosomal RNA, 30S ribosomal protein S11, ...
Authors:Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A.
Deposit date:2020-04-16
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
6YS5
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BU of 6ys5 by Molmil
Acinetobacter baumannii ribosome-amikacin complex - 30S subunit head
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S13, ...
Authors:Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A.
Deposit date:2020-04-21
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
5IU1
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BU of 5iu1 by Molmil
N-terminal PAS domain homodimer of PpANR MAP3K from Physcomitrella patens.
Descriptor: CTR1-like protein, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Stevenson, R.R, Trinh, C.H, Edwards, T.A, Cuming, A.C.
Deposit date:2016-03-17
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance.
Plant Cell, 28, 2016
6YTF
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BU of 6ytf by Molmil
Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit head
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S13, ...
Authors:Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A.
Deposit date:2020-04-24
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
6YX0
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BU of 6yx0 by Molmil
Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid
Descriptor: 4-[[2-(4-oxidanylidenebutanoyl)hydrazinyl]methyl]benzoic acid, PWQ-THR-ARG-LEU, SH3 and multiple ankyrin repeat domains protein 1
Authors:Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J.
Deposit date:2020-04-30
Release date:2021-01-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.
Chem Sci, 12, 2021
6YWZ
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BU of 6ywz by Molmil
Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid
Descriptor: 2-[(~{E})-(4-oxidanylidenebutanoylhydrazinylidene)methyl]benzoic acid, ARGININE, DI(HYDROXYETHYL)ETHER, ...
Authors:Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Lian, L.J, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J.
Deposit date:2020-04-30
Release date:2021-01-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.
Chem Sci, 12, 2021
6YX2
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BU of 6yx2 by Molmil
Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid
Descriptor: 4-[[(~{E})-5-oxidanylidenepentanoyldiazenyl]methyl]benzoic acid, PWW-THR-ARG-LEU, SH3 and multiple ankyrin repeat domains protein 1
Authors:Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Lian, L.J, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J.
Deposit date:2020-04-30
Release date:2021-01-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.
Chem Sci, 12, 2021
6YT9
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BU of 6yt9 by Molmil
Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit body
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
Authors:Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A.
Deposit date:2020-04-24
Release date:2020-09-16
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
6YX1
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BU of 6yx1 by Molmil
Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid
Descriptor: 2-[[2-(5-oxidanylidenepentanoyl)hydrazinyl]methyl]benzoic acid, ARGININE, LEUCINE, ...
Authors:Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Lian, L.J, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J.
Deposit date:2020-04-30
Release date:2021-01-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.
Chem Sci, 12, 2021
6ST2
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BU of 6st2 by Molmil
Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Descriptor: Affimer AF6, Bcl-2-like protein 1, SULFATE ION
Authors:Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2019-09-09
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.
Chembiochem, 22, 2021
6STJ
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BU of 6stj by Molmil
Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Descriptor: Cystatin domain-containing protein, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2019-09-10
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.
Chembiochem, 22, 2021
5A37
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BU of 5a37 by Molmil
Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.
Descriptor: HUMAN ALPHA-ACTININ-2
Authors:Haywood, N.J, Wolny, M, Trinh, C.H, Shuping, Y, Edwards, T.A, Peckham, M.
Deposit date:2015-05-27
Release date:2016-06-22
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
Biochem.J., 473, 2016
5A36
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BU of 5a36 by Molmil
Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.
Descriptor: ALPHA-ACTININ-2
Authors:Haywood, N.J, Wolny, M, Trinh, C.H, Shuping, Y, Edwards, T.A, Peckham, M.
Deposit date:2015-05-27
Release date:2016-06-22
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
Biochem.J., 473, 2016

 

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