Author results

4CSJ
  • Download 4csj
  • View 4csj
Molmil generated image of 4csj
THE DISCOVERY OF POTENT SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS, SUITABLE FOR INHALATION
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Ahlgren, R., Bengtsson, M., Bladh, H., Backstrom, S., Dahmen, J., Henriksson, K., Hillertz, P., Hulikal, V., Jerre, A., Kinchin, L., Kase, C., Lepisto, M., Mile, I., Nilsson, S., Smailagic, A., Taylor, J., Tjornebo, A., Wissler, L., Hansson, T.
Deposit date:2014-03-07
Release date:2014-05-07
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation.
Bioorg.Med.Chem.Lett., 24, 2014
1GU8
  • Download 1gu8
  • View 1gu8
Molmil generated image of 1gu8
SENSORY RHODOPSIN II
Descriptor:SENSORY RHODOPSIN II, RETINAL, CHLORIDE ION
Authors:Edman, K., Royant, A., Nollert, P., Maxwell, C.A., Pebay-Peyroula, E., Navarro, J., Neutze, R., Landau, E.M.
Deposit date:2002-01-24
Release date:2002-04-12
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Early Structural Rearrangements in the Photocycle of an Integral Membrane Sensory Receptor
Structure, 10, 2002
1GUE
  • Download 1gue
  • View 1gue
Molmil generated image of 1gue
SENSORY RHODOPSIN II
Descriptor:SENSORY RHODOPSIN II, RETINAL, CHLORIDE ION
Authors:Edman, K., Royant, A., Nollert, P., Maxwell, C.A., Pebay-Peyroula, E., Navarro, J., Neutze, R., Landau, E.M.
Deposit date:2002-01-24
Release date:2002-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Early Structural Rearrangements in the Photocycle of an Integral Membrane Sensory Receptor
Structure, 10, 2002
1QKO
  • Download 1qko
  • View 1qko
Molmil generated image of 1qko
HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE
Descriptor:BACTERIORHODOPSIN, RETINAL
Authors:Edman, K., Nollert, P., Royant, A., Belrhali, H., Pebay-Peyroula, E., Hajdu, J., Neutze, R., Landau, E.M.
Deposit date:1999-07-30
Release date:1999-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High Resolution X-Ray Structure of an Early Intermediate in the Bacteriorhodopsin Photocycle
Nature, 401, 1999
1QKP
  • Download 1qkp
  • View 1qkp
Molmil generated image of 1qkp
HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE
Descriptor:BACTERIORHODOPSIN, RETINAL
Authors:Edman, K., Nollert, P., Royant, A., Belrhali, H., Pebay-Peyroula, E., Hajdu, J., Neutze, R., Landau, E.M.
Deposit date:1999-07-30
Release date:1999-10-24
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle.
Nature, 401, 1999
1VJM
  • Download 1vjm
  • View 1vjm
Molmil generated image of 1vjm
DEFORMATION OF HELIX C IN THE LOW-TEMPERATURE L-INTERMEDIATE OF BACTERIORHODOPSIN
Descriptor:Bacteriorhodopsin, RETINAL
Authors:Edman, K., Royant, A., Larsson, G., Jacobson, F., Taylor, T., van der Spoel, D., Landau, E.M., Pebay-Peyroula, E., Neutze, R.
Deposit date:2004-03-12
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Deformation of helix C in the low temperature L-intermediate of bacteriorhodopsin.
J.Biol.Chem., 279, 2004
2Y6C
  • Download 2y6c
  • View 2y6c
Molmil generated image of 2y6c
THE DISCOVERY OF MMP7 INHIBITORS EXPLOITING A NOVEL SELECTIVITY TRIGGER
Descriptor:MATRILYSIN, CALCIUM ION, ZINC ION, ...
Authors:Edman, K., Furber, M., Hemsley, P., Johansson, C., Pairaudeau, G., Petersen, J., Stocks, M., Tervo, A., Ward, A., Wells, E., Wissler, L.
Deposit date:2011-01-20
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.
Chemmedchem, 6, 2011
2Y6D
  • Download 2y6d
  • View 2y6d
Molmil generated image of 2y6d
THE DISCOVERY OF MMP7 INHIBITORS EXPLOITING A NOVEL SELECTIVITY TRIGGER
Descriptor:MATRILYSIN, CALCIUM ION, ZINC ION, ...
Authors:Edman, K., Furber, M., Hemsley, P., Johansson, C., Pairaudeau, G., Petersen, J., Stocks, M., Tervo, A., Ward, A., Wells, E., Wissler, L.
Deposit date:2011-01-20
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.
Chemmedchem, 6, 2011
4UDA
  • Download 4uda
  • View 4uda
Molmil generated image of 4uda
MR IN COMPLEX WITH DEXAMETHASONE
Descriptor:MINERALOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 1, GLYCEROL, ...
Authors:Edman, K., Hogner, A., Hussein, A., Bjursell, M., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., Jellesmark-Jensen, T., Cavallin, A., Karlsson, U., Nilsson, E., Lecina, D., Takahashi, R., Grebner, C., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDB
  • Download 4udb
  • View 4udb
Molmil generated image of 4udb
MR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE
Descriptor:MINERALOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 1, DIMETHYL SULFOXIDE, ...
Authors:Edman, K., Hogner, A., Hussein, A., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., JellesmarkJensen, T., Cavallin, A., Nilsson, E., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDC
  • Download 4udc
  • View 4udc
Molmil generated image of 4udc
GR IN COMPLEX WITH DEXAMETHASONE
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Edman, K., Hogner, A., Hussein, A., Bjursell, M., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., Jellesmark-Jensen, T., Cavallin, A., Karlsson, U., Nilsson, E., Lecina, D., Takahashi, R., Grebner, C., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDD
  • Download 4udd
  • View 4udd
Molmil generated image of 4udd
GR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Edman, K., Hogner, A., Hussein, A., Bjursell, M., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., Jellesmark-Jensen, T., Cavallin, A., Karlsson, U., Nilsson, E., Lecina, D., Takahashi, R., Grebner, C., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
5L7E
  • Download 5l7e
  • View 5l7e
Molmil generated image of 5l7e
MCR IN COMPLEX WITH LIGAND
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Edman, K., Aagaard, A., Backstrom, S., Xue, Y.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5L7G
  • Download 5l7g
  • View 5l7g
Molmil generated image of 5l7g
MCR IN COMPLEX WITH LIGAND
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Aagaard, A., Backstrom, S., Xue, Y.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5MWP
  • Download 5mwp
  • View 5mwp
Molmil generated image of 5mwp
THE STRUCTURE OF MR IN COMPLEX WITH AZD9977.
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, 2-[(3~{S})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide
Authors:Edman, K., Aagaard, A., Backstrom, S.
Deposit date:2017-01-19
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
PLoS ONE, 13, 2018
5MWY
  • Download 5mwy
  • View 5mwy
Molmil generated image of 5mwy
THE STRUCTURE OF MR IN COMPLEX WITH EPLERENONE.
Descriptor:Mineralocorticoid receptor, NCOA1, eplerenone
Authors:Edman, K., Aagaard, A., Backstrom, S.
Deposit date:2017-01-20
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
PLoS ONE, 13, 2018
5NFP
  • Download 5nfp
  • View 5nfp
Molmil generated image of 5nfp
GLUCOCORTICOID RECEPTOR IN COMPLEX WITH BUDESONIDE
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Edman, K., Wissler, L.
Deposit date:2017-03-15
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J. Med. Chem., 60, 2017
5NFT
  • Download 5nft
  • View 5nft
Molmil generated image of 5nft
GLUCOCORTICOID RECEPTOR IN COMPLEX WITH AZD5423
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Wissler, L.
Deposit date:2017-03-15
Release date:2017-10-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J. Med. Chem., 60, 2017
6EL6
  • Download 6el6
  • View 6el6
Molmil generated image of 6el6
GLUCOCORTICOID RECEPTOR IN COMPLEX WITH COMPOUND 4
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Wissler, L.
Deposit date:2017-09-28
Release date:2018-02-21
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61, 2018
6EL7
  • Download 6el7
  • View 6el7
Molmil generated image of 6el7
GLUCOCORTICOID RECEPTOR IN COMPLEX WITH COMPOUND 31
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Wissler, L.
Deposit date:2017-09-28
Release date:2018-02-21
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61, 2018
6EL9
  • Download 6el9
  • View 6el9
Molmil generated image of 6el9
GLUCOCORTICOID RECEPTOR IN COMPLEX WITH AZD9567
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Wissler, L.
Deposit date:2017-09-28
Release date:2018-02-21
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61, 2018
6GEV
  • Download 6gev
  • View 6gev
Molmil generated image of 6gev
MINERALOCORTICOID RECEPTOR IN COMPLEX WITH (S)-13
Descriptor:Mineralocorticoid receptor, Nuclear receptor coactivator 1, GLYCEROL, ...
Authors:Edman, K., Aagaard, A., Tangefjord, S.
Deposit date:2018-04-27
Release date:2019-01-09
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
J. Med. Chem., 2019
6GG8
  • Download 6gg8
  • View 6gg8
Molmil generated image of 6gg8
MINERALOCORTICOID RECEPTOR IN COMPLEX WITH (S)-13
Descriptor:Mineralocorticoid receptor, Nuclear receptor coactivator 1, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Edman, K., Aagaard, A., Tangefjord, S.
Deposit date:2018-05-03
Release date:2019-01-09
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
J. Med. Chem., 2019
6GGG
  • Download 6ggg
  • View 6ggg
Molmil generated image of 6ggg
MINERALOCORTICOID RECEPTOR IN COMPLEX WITH (S)-13
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, CHLORIDE ION, ...
Authors:Edman, K., Aagaard, A., Tangefjord, S.
Deposit date:2018-05-03
Release date:2019-01-09
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
J. Med. Chem., 2019
2VCQ
  • Download 2vcq
  • View 2vcq
Molmil generated image of 2vcq
COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 1.95A.
Descriptor:GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole
Authors:Hohwy, M., Spadola, L., Lundquist, B., von Wachenfeldt, K., Persdotter, S., Hawtin, P., Dahmen, J., Groth-Clausen, I., Folmer, R.H.A., Edman, K.
Deposit date:2007-09-26
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
<123>
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan