Author results

1TNF
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THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING
Descriptor:TUMOR NECROSIS FACTOR-ALPHA
Authors:Eck, M.J., Sprang, S.R.
Deposit date:1989-08-25
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
J.Biol.Chem., 264, 1989
4K11
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THE STRUCTURE OF 1NA IN COMPLEX WITH SRC T338G
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Eck, M.J., Yun, C.H.
Deposit date:2013-04-04
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of 1NA in complex with Src T338G
To be Published
1QZY
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HUMAN METHIONINE AMINOPEPTIDASE IN COMPLEX WITH BENGAMIDE INHIBITOR LAF153 AND COBALT
Descriptor:Methionine aminopeptidase 2, COBALT (II) ION, (E)-(2R,3R,4S,5R)-3,4,5-TRIHYDROXY-2-METHOXY-8,8-DIMETHYL-NON-6-ENOIC ACID ((3S,6R)-6-HYDROXY-2-OXO-AZEPAN-3-YL)-AMIDE, ...
Authors:Eck, M.J., Song, H.K., Morollo, A.
Deposit date:2003-09-18
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.
J.Biol.Chem., 278, 2003
3O4X
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CRYSTAL STRUCTURE OF COMPLEX BETWEEN AMINO AND CARBOXY TERMINAL FRAGMENTS OF MDIA1
Descriptor:Protein diaphanous homolog 1
Authors:Eck, M.J., Nezami, A., Toms, A.V.
Deposit date:2010-07-27
Release date:2010-10-13
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins.
Plos One, 5, 2010
4WYB
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STRUCTURE OF THE BUD6 FLANK DOMAIN IN COMPLEX WITH ACTIN
Descriptor:Actin, alpha skeletal muscle, Bud site selection protein 6, ...
Authors:Eck, M.J., Park, E., Zheng, W.
Deposit date:2014-11-17
Release date:2015-08-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.493 Å)
Cite:Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Structure, 23, 2015
4ZJV
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CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH MITOGEN-INDUCIBLE GENE 6 PROTEIN
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1
Authors:Eck, M.J., Park, E., Lee, B.
Deposit date:2015-04-29
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
5U1M
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STRUCTURE OF THE IRS-1 PTB DOMAIN BOUND TO THE JUXTAMEMBRANE REGION OF THE INSULIN RECEPTOR
Descriptor:Insulin receptor substrate 1, Insulin receptor
Authors:Eck, M.J., Dhe-Paganon, S.
Deposit date:2016-11-28
Release date:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
Nat Commun, 8, 2017
1I3Z
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MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor:EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Lu, J., Poy, F., Morra, M., Terhorst, C., Eck, M.J.
Deposit date:2001-02-19
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Eur.J.Biochem., 20, 2001
4Z16
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CRYSTAL STRUCTURE OF THE JAK3 KINASE DOMAIN COVALENTLY BOUND TO N-(3-(((5-CHLORO-2-((2-METHOXY-4-(4-METHYLPIPERAZIN-1-YL)PHENYL)AMINO)PYRIMIDIN-4-YL)AMINO)METHYL)PHENYL)ACRYLAMIDE
Descriptor:Tyrosine-protein kinase JAK3, N-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide
Authors:McNally, R., Tan, L., Gray, N.S., Eck, M.J.
Deposit date:2015-03-26
Release date:2016-02-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Development of Selective Covalent Janus Kinase 3 Inhibitors.
J.Med.Chem., 58, 2015
5CZH
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EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE
Descriptor:Epidermal growth factor receptor, Peptide substrate
Authors:Yun, C.H., Eck, M.J.
Deposit date:2015-07-31
Release date:2015-09-30
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Nat.Struct.Mol.Biol., 22, 2015
5CZI
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EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE
Descriptor:Epidermal growth factor receptor, SHC Peptide substrate
Authors:Yun, C.H., Eck, M.J.
Deposit date:2015-07-31
Release date:2015-09-30
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Nat.Struct.Mol.Biol., 22, 2015
1B47
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STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
Descriptor:CBL, CALCIUM ION
Authors:Meng, W., Sawasdikosol, S., Burakoff, S.J., Eck, M.J.
Deposit date:1999-01-06
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
Descriptor:SAP SH2 DOMAIN, SULFATE ION
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-09-22
Release date:1999-10-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1EG3
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STRUCTURE OF A DYSTROPHIN WW DOMAIN FRAGMENT IN COMPLEX WITH A BETA-DYSTROGLYCAN PEPTIDE
Descriptor:DYSTROPHIN
Authors:Huang, X., Poy, F., Zhang, R., Joachimiak, A., Sudol, M., Eck, M.J.
Deposit date:2000-02-11
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Nat.Struct.Biol., 7, 2000
1EG4
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STRUCTURE OF A DYSTROPHIN WW DOMAIN FRAGMENT IN COMPLEX WITH A BETA-DYSTROGLYCAN PEPTIDE
Descriptor:BETA-DYSTROGLYCAN, DYSTROPHIN
Authors:Huang, X., Poy, F., Zhang, R., Joachimiak, A., Sudol, M., Eck, M.J.
Deposit date:2000-02-11
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Nat.Struct.Biol., 7, 2000
1F3M
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CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA, IODIDE ION
Authors:Lei, M., Lu, W., Meng, W., Parrini, M.-C., Eck, M.J., Mayer, B.J., Harrison, S.C.
Deposit date:2000-06-05
Release date:2000-06-29
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell(Cambridge,Mass.), 102, 2000
1FMK
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CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
Descriptor:TYROSINE-PROTEIN KINASE SRC
Authors:Xu, W., Harrison, S.C., Eck, M.J.
Deposit date:1997-01-24
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385, 1997
1I1Q
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STRUCTURE OF THE COOPERATIVE ALLOSTERIC ANTHRANILATE SYNTHASE FROM SALMONELLA TYPHIMURIUM
Descriptor:ANTHRANILATE SYNTHASE COMPONENT I, ANTHRANILATE SYNTHASE COMPONENT II, TRYPTOPHAN
Authors:Morollo, A.A., Eck, M.J.
Deposit date:2001-02-02
Release date:2001-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium.
Nat.Struct.Biol., 8, 2001
1IJQ
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CRYSTAL STRUCTURE OF THE LDL RECEPTOR YWTD-EGF DOMAIN PAIR
Descriptor:LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Jeon, H., Meng, W., Takagi, J., Eck, M.J., Springer, T.A., Blacklow, S.C.
Deposit date:2001-04-27
Release date:2001-05-23
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nat.Struct.Biol., 8, 2001
1JPW
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CRYSTAL STRUCTURE OF A HUMAN TCF-4 / BETA-CATENIN COMPLEX
Descriptor:BETA-CATENIN, transcription factor 7-like 2
Authors:Poy, F., Lepourcelet, M., Shivdasani, R.A., Eck, M.J.
Deposit date:2001-08-03
Release date:2001-12-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a human Tcf4-beta-catenin complex.
Nat.Struct.Biol., 8, 2001
1KSW
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STRUCTURE OF HUMAN C-SRC TYROSINE KINASE (THR338GLY MUTANT) IN COMPLEX WITH N6-BENZYL ADP
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N6-BENZYL ADENOSINE-5'-DIPHOSPHATE
Authors:Witucki, L.A., Huang, X., Shah, K., Liu, Y., Kyin, S., Eck, M.J., Shokat, K.M.
Deposit date:2002-01-14
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
Chem.Biol., 9, 2002
1L3E
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NMR STRUCTURES OF THE HIF-1ALPHA CTAD/P300 CH1 COMPLEX
Descriptor:hypoxia inducible factor-1 alpha subunit, p300 protein, ZINC ION
Authors:Freedman, S.J., Sun, Z.J., Poy, F., Kung, A.L., Livingston, D.M., Wagner, G., Eck, M.J.
Deposit date:2002-02-26
Release date:2002-04-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proc.Natl.Acad.Sci.USA, 99, 2002
1M27
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CRYSTAL STRUCTURE OF SAP/FYNSH3/SLAM TERNARY COMPLEX
Descriptor:SH2 domain protein 1A, Signaling lymphocytic activation molecule, Proto-oncogene tyrosine-protein kinase FYN, ...
Authors:Chan, B., Griesbach, J., Song, H.K., Poy, F., Terhorst, C., Eck, M.J.
Deposit date:2002-06-21
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:SAP couples Fyn to SLAM immune receptors.
NAT.CELL BIOL., 5, 2003