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1PZL
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CRYSTAL STRUCTURE OF HNF4A LBD IN COMPLEX WITH THE LIGAND AND THE COACTIVATOR SRC-1 PEPTIDE
Descriptor:Hepatocyte nuclear factor 4-alpha, steroid receptor coactivator-1, MYRISTIC ACID
Authors:Duda, K., Chi, Y.-I., Dhe-paganon, S., Shoelson, S.
Deposit date:2003-07-11
Release date:2004-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for HNF-4alpha Activation by Ligand and Coactivator Binding
J.Biol.Chem., 279, 2004
1M7W
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HNF4A LIGAND BINDING DOMAIN WITH BOUND FATTY ACID
Descriptor:Hepatocyte nuclear factor 4-alpha, LAURIC ACID
Authors:Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y.I., Shoelson, S.E.
Deposit date:2002-07-22
Release date:2003-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
4D9T
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RSK2 C-TERMINAL KINASE DOMAIN WITH INHIBITOR (E)-METHYL 3-(4-AMINO-7-(3-HYDROXYPROPYL)-5-P-TOLYL-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-2-CYANOACRYLATE
Descriptor:Ribosomal protein S6 kinase alpha-3, methyl (2S)-3-{4-amino-7-[(1E)-3-hydroxyprop-1-en-1-yl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl}-2-cyanopropanoate, SODIUM ION
Authors:Serafimova, I.M., Pufall, M.A., Krishnan, S., Duda, K., Cohen, M.S., Maglathlin, R.L., McFarland, J.M., Miller, R.M., Frodin, M., Taunton, J.
Deposit date:2012-01-12
Release date:2012-04-25
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
Nat.Chem.Biol., 8, 2012
4D9U
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RSK2 C-TERMINAL KINASE DOMAIN, (E)-TERT-BUTYL 3-(4-AMINO-7-(3-HYDROXYPROPYL)-5-P-TOLYL-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-2-CYANOACRYLATE
Descriptor:Ribosomal protein S6 kinase alpha-3, tert-butyl (2S)-3-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyanopropanoate, SODIUM ION
Authors:Serafimova, I.M., Pufall, M.A., Krishnan, S., Duda, K., Cohen, M.S., Maglathlin, R.L., McFarland, J.M., Miller, R.M., Frodin, M., Taunton, J.
Deposit date:2012-01-12
Release date:2012-04-11
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
Nat.Chem.Biol., 8, 2012