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5WZ1
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CRYSTAL STRUCTURE OF ZIKA VIRUS NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL-L-METHIONINE
Descriptor:NS5 methyltransferase, S-ADENOSYLMETHIONINE
Authors:Duan, W., Song, H., Qi, J., Shi, Y., Gao, G.F.
Deposit date:2017-01-16
Release date:2017-03-08
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.507 Å)
Cite:The crystal structure of Zika virus NS5 reveals conserved drug targets.
EMBO J., 36, 2017
5WZ2
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CRYSTAL STRUCTURE OF ZIKA VIRUS NS5 METHYLTRANSFERASE BOUND TO SAM AND RNA ANALOGUE (M7GPPPA)
Descriptor:NS5 MTase, S-ADENOSYLMETHIONINE, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE
Authors:Duan, W., Song, H., Qi, J., Shi, Y., Gao, G.F.
Deposit date:2017-01-16
Release date:2017-03-08
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of Zika virus NS5 reveals conserved drug targets.
EMBO J., 36, 2017
5WZ3
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CRYSTAL STRUCTURE OF ZIKA VIRUS NS5 RNA-DEPENDENT RNA POLYMERASE(RDRP)
Descriptor:NS5 RdRp, ZINC ION
Authors:Duan, W., Song, H., Qi, J., Shi, Y., Gao, G.F.
Deposit date:2017-01-16
Release date:2017-03-08
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:The crystal structure of Zika virus NS5 reveals conserved drug targets.
EMBO J., 36, 2017
4J12
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MONOMERIC FC
Descriptor:human Fc fragment, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Ishino, T., Wang, M., Mosyak, L., Tam, A., Duan, W., Svenson, K., Joyce, A., O'Hara, D., Lin, L., Somers, W., Kriz, R.
Deposit date:2013-01-31
Release date:2013-05-01
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics.
J.Biol.Chem., 288, 2013
5EOB
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CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH NOVEL INHIBITOR
Descriptor:Hepatocyte growth factor receptor, 6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline
Authors:Liu, Q., Chen, T., Xu, Y.
Deposit date:2015-11-10
Release date:2016-10-19
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor
Eur.J.Med.Chem., 116, 2016