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6VTI
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BU of 6vti by Molmil
Solution NMR structure of the N-terminal domain of the Serine/threonine-protein phosphatase 1 regulatory subunit 10, PPP1R10
Descriptor: Serine/threonine-protein phosphatase 1 regulatory subunit 10
Authors:Lemak, A, Wei, Y, Duan, S, Houliston, S, Penn, L.Z, Arrowsmith, C.H.
Deposit date:2020-02-12
Release date:2020-02-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Nucleic Acids Res., 50, 2022
7LQT
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BU of 7lqt by Molmil
Solution NMR structure of the PNUTS amino-terminal Domain fused to Myc Homology Box 0
Descriptor: Serine/threonine-protein phosphatase 1 regulatory subunit 10,Myc proto-oncogene protein fusion
Authors:Lemak, A, Wei, Y, Duan, S, Houliston, S, Penn, L.Z, Arrowsmith, C.H.
Deposit date:2021-02-15
Release date:2021-03-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Nucleic Acids Res., 50, 2022
4TVR
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BU of 4tvr by Molmil
Tandem Tudor and PHD domains of UHRF2
Descriptor: E3 ubiquitin-protein ligase UHRF2, UNKNOWN ATOM OR ION, ZINC ION
Authors:Walker, J.R, Dong, A, Zhang, Q, Ong, M, Duan, S, Li, Y, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2015-06-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of the Tandem Tudor and PHD domains of UHRF2
To be published
6VFO
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BU of 6vfo by Molmil
Solution structure of the PHD of mouse UHRF1 (NP95)
Descriptor: E3 ubiquitin-protein ligase UHRF1, ZINC ION
Authors:Lemak, A, Houliston, S, Duan, S, Arrowsmith, C.H.
Deposit date:2020-01-06
Release date:2020-06-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Nucleic Acids Res., 48, 2020
6VED
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BU of 6ved by Molmil
Solution structure of the TTD and linker region of UHRF1
Descriptor: E3 ubiquitin-protein ligase UHRF1
Authors:Lemak, A, Houliston, S, Duan, S, Ong, M.S, Arrowsmith, C.H.
Deposit date:2019-12-31
Release date:2020-06-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Nucleic Acids Res., 48, 2020
6VEE
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BU of 6vee by Molmil
Solution structure of the TTD and linker region of mouse UHRF1 (NP95)
Descriptor: E3 ubiquitin-protein ligase UHRF1
Authors:Lemak, A, Houliston, S, Duan, S, Arrowsmith, C.H.
Deposit date:2019-12-31
Release date:2020-06-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Nucleic Acids Res., 48, 2020
3H8H
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BU of 3h8h by Molmil
Structure of the C-terminal domain of human RNF2/RING1B;
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase RING2, GLYCEROL, ...
Authors:Walker, J.R, Bezsonova, I, Bacik, J, Duan, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2009-04-29
Release date:2009-06-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.
Biochemistry, 48, 2009
2JUF
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BU of 2juf by Molmil
NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto
Descriptor: p53-associated parkin-like cytoplasmic protein
Authors:Kaustov, L, Liao, J.C.C, Lemak, S, Duan, S, Muhandiram, R, Karra, M, Srisailam, S.H, Sundstrom, M, Weigelt, J, Edwards, A.M, Dhe-Paganon, S, Arrowsmith, C.H, Structural Genomics Consortium (SGC), Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-08-23
Release date:2007-10-16
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:NMR Solution Structure of PARC CPH Domain.
To be Published
2K2D
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BU of 2k2d by Molmil
Solution NMR structure of C-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2C
Descriptor: RING finger and CHY zinc finger domain-containing protein 1, ZINC ION
Authors:Lemak, A, Sheng, Y, Karra, M, Srisailam, S, Laister, R.C, Duan, S, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2020-02-19
Method:SOLUTION NMR
Cite:Molecular basis of Pirh2-mediated p53 ubiquitylation.
Nat.Struct.Mol.Biol., 15, 2008
3B6Y
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BU of 3b6y by Molmil
Crystal Structure of the Second HIN-200 Domain of Interferon-Inducible Protein 16
Descriptor: Gamma-interferon-inducible protein Ifi-16, SULFATE ION
Authors:Liao, J.C.C, Lam, R, Ravichandran, M, Duan, S, Tempel, W, Chirgadze, N.Y, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-10-29
Release date:2007-11-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure Analysis of the Second HIN Domain of IFI16.
To be Published
2FOJ
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BU of 2foj by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
Authors:Saridakis, V, Sheng, Y, Sarkari, F, Duan, S, Wu, T, Arrowsmith, C.H, Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOP
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BU of 2fop by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, mdm2 peptide
Authors:Saridakis, V, Sheng, Y, Sarkari, F, Duan, S, Wu, T, Arrowsmith, C.H, Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOO
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BU of 2foo by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
Authors:Saridakis, V, Sheng, Y, Sarkari, F, Duan, S, Wu, T, Arrowsmith, C.H, Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2JNG
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BU of 2jng by Molmil
Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.
Descriptor: Cullin-7
Authors:Lemak, A, Kaustov, L, Lukin, J, Duan, S, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-01-23
Release date:2007-02-27
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:The Conserved CPH Domains of Cul7 and PARC Are Protein-Protein Interaction Modules That Bind the Tetramerization Domain of p53
J.Biol.Chem., 282, 2007
5YZ1
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BU of 5yz1 by Molmil
Crystal structure of human Archease
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Protein archease
Authors:Duan, S.Y, Li, J.X.
Deposit date:2017-12-11
Release date:2019-01-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of human archease, a key cofactor of tRNA splicing ligase complex.
Int.J.Biochem.Cell Biol., 122, 2020
6BW3
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BU of 6bw3 by Molmil
Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide
Descriptor: Histone-binding protein RBBP4, MDS1 and EVI1 complex locus protein MDS1, UNKNOWN ATOM OR ION
Authors:Ivanochko, D, Halabelian, L, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2017-12-14
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Nucleic Acids Res., 47, 2019
6BW4
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BU of 6bw4 by Molmil
Crystal structure of RBBP4 in complex with PRDM16 N-terminal peptide
Descriptor: Histone-binding protein RBBP4, PR domain zinc finger protein 16, UNKNOWN ATOM OR ION
Authors:Ivanochko, D, Halabelian, L, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2017-12-14
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Nucleic Acids Res., 47, 2019
2L3R
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BU of 2l3r by Molmil
NMR structure of UHRF1 Tandem Tudor Domains in a complex with Histone H3 peptide
Descriptor: E3 ubiquitin-protein ligase UHRF1, Histone H3
Authors:Nady, N, Lemak, A, Fares, C, Gutmanas, A, Avvakumov, G, Xue, S, Arrowsmith, C, Structural Genomics Consortium (SGC)
Deposit date:2010-09-21
Release date:2011-04-13
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein.
J.Biol.Chem., 286, 2011
4QJK
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BU of 4qjk by Molmil
Crystal structure of M. tuberculosis phosphopantetheinyl transferase PptT
Descriptor: COENZYME A, Phosphopantetheinyl transferase PptT, SULFATE ION
Authors:Noel, J.P, Burkart, M.D, Vickery, C.R.
Deposit date:2014-06-04
Release date:2014-07-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
4QJL
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BU of 4qjl by Molmil
Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT
Descriptor: COENZYME A, MAGNESIUM ION, Phosphopantetheinyl transferase, ...
Authors:Noel, J.P, Burkart, M.D, Vickery, C.R.
Deposit date:2014-06-04
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of mycobacteria.
Acs Chem.Biol., 9, 2014
3BI7
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BU of 3bi7 by Molmil
Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF1
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION, ...
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2007-11-30
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature, 455, 2008
3CLZ
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BU of 3clz by Molmil
The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA
Descriptor: 5'-D(*DCP*DCP*DCP*DTP*DGP*DCP*DGP*DGP*DGP*DCP*DCP*DC)-3', 5'-D(*DGP*DGP*DGP*DCP*DCP*(5CM)P*DGP*DCP*DAP*DGP*DGP*DG)-3', E3 ubiquitin-protein ligase UHRF1
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Dong, A, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2008-03-20
Release date:2008-04-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature, 455, 2008
3DB4
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BU of 3db4 by Molmil
Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1
Descriptor: E3 ubiquitin-protein ligase UHRF1, SULFATE ION
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Dong, A, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2008-05-30
Release date:2008-09-16
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
J.Biol.Chem., 286, 2011
3DB3
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BU of 3db3 by Molmil
Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1 in complex with trimethylated histone H3-K9 peptide
Descriptor: E3 ubiquitin-protein ligase UHRF1, Trimethylated histone H3-K9 peptide
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Dong, A, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2008-05-30
Release date:2008-09-16
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
J.Biol.Chem., 286, 2011
4FL6
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BU of 4fl6 by Molmil
Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215
Descriptor: Lethal(3)malignant brain tumor-like protein 3, UNKNOWN ATOM OR ION, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone}
Authors:Zhong, N, Tempel, W, Ravichandran, M, Dong, A, Ingerman, L.A, Graslund, S, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
Nat. Chem. Biol., 9, 2013

 

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