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5MWJ
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STRUCTURE ENABLED DISCOVERY OF A STAPLED PEPTIDE INHIBITOR TO TARGET THE ONCOGENIC TRANSCRIPTIONAL REPRESSOR TLE1
分子名称:Transducin-like enhancer protein 1, DIMETHYL SULFOXIDE, pepide inhibtor
著者McGrath, S., Tortorici, M., Vidler, L., Drouin, L., Westwood, I., Gimeson, P., Van Montfort, R., Hoelder, S.
登録日2017-01-18
公開日2017-04-05
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.
Chemistry, 23, 2017
4XUA
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH E11919 BAZ2-ICR ANALOGUE
分子名称:Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 4-{1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-4-phenyl-1H-imidazol-5-yl}benzonitrile
著者Chaikuad, A., Felletar, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2015-01-25
公開日2015-03-11
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
J.Med.Chem., 58, 2015
4XUB
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH BAZ2-ICR CHEMICAL PROBE
分子名称:Bromodomain adjacent to zinc finger domain protein 2B, 4-{4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-1H-imidazol-5-yl}benzonitrile, 1,2-ETHANEDIOL
著者Chaikuad, A., Felletar, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2015-01-25
公開日2015-03-11
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
J.Med.Chem., 58, 2015
6CBE
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ATOMIC STRUCTURE OF A RATIONALLY ENGINEERED GENE DELIVERY VECTOR, AAV2.5
分子名称:Capsid protein VP1
著者Burg, M., Rosebrough, C., Drouin, L., Bennett, A., Mietzsch, M., Chipman, P., McKenna, R., Sousa, D., Potter, M., Byrne, B., Kozyreva, O.G., Samulski, R.J., Agbandje-McKenna, M.
登録日2018-02-02
公開日2018-05-30
最終更新日2018-08-29
実験手法ELECTRON MICROSCOPY (2.78 Å)
主引用文献Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
J. Struct. Biol., 203, 2018
5LSS
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSU
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase NSD2, ZINC ION, S-ADENOSYLMETHIONINE
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSX
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, [(2~{R},5~{S})-1-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]-5-azaniumyl-6-oxidanyl-6-oxidanylidene-hexan-2-yl]-(phenylmethyl)azanium
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSY
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-12
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSZ
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT6
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-06
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT7
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-06
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT8
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, SINEFUNGIN
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-06
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016