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5MWJ
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STRUCTURE ENABLED DISCOVERY OF A STAPLED PEPTIDE INHIBITOR TO TARGET THE ONCOGENIC TRANSCRIPTIONAL REPRESSOR TLE1
Descriptor:Transducin-like enhancer protein 1, DIMETHYL SULFOXIDE, pepide inhibtor
Authors:McGrath, S., Tortorici, M., Vidler, L., Drouin, L., Westwood, I., Gimeson, P., Van Montfort, R., Hoelder, S.
Deposit date:2017-01-18
Release date:2017-04-05
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.
Chemistry, 23, 2017
4XUA
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH E11919 BAZ2-ICR ANALOGUE
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 4-{1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-4-phenyl-1H-imidazol-5-yl}benzonitrile
Authors:Chaikuad, A., Felletar, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2015-01-25
Release date:2015-03-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
J.Med.Chem., 58, 2015
4XUB
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH BAZ2-ICR CHEMICAL PROBE
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 4-{4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-1H-imidazol-5-yl}benzonitrile, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Felletar, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2015-01-25
Release date:2015-03-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
J.Med.Chem., 58, 2015
6CBE
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ATOMIC STRUCTURE OF A RATIONALLY ENGINEERED GENE DELIVERY VECTOR, AAV2.5
Descriptor:Capsid protein VP1
Authors:Burg, M., Rosebrough, C., Drouin, L., Bennett, A., Mietzsch, M., Chipman, P., McKenna, R., Sousa, D., Potter, M., Byrne, B., Kozyreva, O.G., Samulski, R.J., Agbandje-McKenna, M.
Deposit date:2018-02-02
Release date:2018-05-30
Last modified:2018-08-29
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
J. Struct. Biol., 203, 2018
5LSS
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
Authors:Tisi, D., Pathuri, P.
Deposit date:2016-09-05
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSU
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase NSD2, ZINC ION, S-ADENOSYLMETHIONINE
Authors:Tisi, D., Pathuri, P., Heightman, T.
Deposit date:2016-09-05
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSX
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, [(2~{R},5~{S})-1-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]-5-azaniumyl-6-oxidanyl-6-oxidanylidene-hexan-2-yl]-(phenylmethyl)azanium
Authors:Tisi, D., Pathuri, P., Heightman, T.
Deposit date:2016-09-05
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSY
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
Authors:Tisi, D., Pathuri, P., Heightman, T.
Deposit date:2016-09-05
Release date:2016-10-12
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSZ
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
Authors:Tisi, D., Pathuri, P., Heightman, T.
Deposit date:2016-09-05
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT6
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
Authors:Tisi, D., Pathuri, P., Heightman, T.
Deposit date:2016-09-06
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT7
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
Authors:Tisi, D., Pathuri, P., Heightman, T.
Deposit date:2016-09-06
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT8
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
Descriptor:Histone-lysine N-methyltransferase SETD2, ZINC ION, SINEFUNGIN
Authors:Tisi, D., Pathuri, P., Heightman, T.
Deposit date:2016-09-06
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016