Author results

4ATZ
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AD5 KNOB IN COMPLEX WITH A DESIGNED ANKYRIN REPEAT PROTEIN
Descriptor:Fiber protein, DESIGNED ANKYRIN REPEAT PROTEIN
Authors:Mittl, P.R.E., Hess, C., Dreier, B.
Deposit date:2012-05-11
Release date:2013-02-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4DUI
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DARPIN D1 BINDING TO TUBULIN BETA CHAIN (NOT IN COMPLEX)
Descriptor:DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1, (4S)-2-METHYL-2,4-PENTANEDIOL, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Pecqueur, L., Duellberg, C., Dreier, B., Wang, Q., Jiang, C., Pluckthun, A., Surrey, T., Gigant, B., Knossow, M.
Deposit date:2012-02-22
Release date:2013-02-27
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:An Anti-Tubulin Darpin Caps the Microtubule Plus-End
To be Published
3HG0
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CRYSTAL STRUCTURE OF A DARPIN IN COMPLEX WITH ORF49 FROM LACTOCOCCAL PHAGE TP901-1
Descriptor:Baseplate protein, Designed Ankyrin Repeat Protein (DARPin) 20
Authors:Veesler, D., Dreier, B., Blangy, S., Lichiere, J., Tremblay, D., Moineau, S., Spinelli, S., Tegoni, M., Pluckthun, A., Campanacci, V., Cambillau, C.
Deposit date:2009-05-13
Release date:2009-09-08
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode.
J.Biol.Chem., 284, 2009
5OGI
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COMPLEX OF A BINDING PROTEIN AND HUMAN ADENOVIRUS C 5 HEXON
Descriptor:Hexon protein, scFv of 9C12 antibody, SULFATE ION, ...
Authors:Schmid, M., Ernst, P., Honegger, A., Suomalainen, M., Zimmermann, M., Braun, L., Stauffer, S., Thom, C., Dreier, B., Eibauer, M., Kipar, A., Vogel, V., Greber, U.F., Medalia, O., Plueckthun, A.
Deposit date:2017-07-13
Release date:2018-02-07
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Nat Commun, 9, 2018
6EQC
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CRYO-EM RECONSTRUCTION OF A COMPLEX OF A BINDING PROTEIN AND HUMAN ADENOVIRUS C5 HEXON
Descriptor:Hexon protein, scFv of 9C12 antibody
Authors:Schmid, M., Ernst, P., Honegger, A., Suomalainen, M., Zimmermann, M., Braun, L., Stauffer, S., Thom, C., Dreier, B., Eibauer, M., Kipar, A., Vogel, V., Greber, U.F., Medalia, O., Plueckthun, A.
Deposit date:2017-10-12
Release date:2018-02-07
Last modified:2018-02-14
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Nat Commun, 9, 2018
4DRX
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GTP-TUBULIN IN COMPLEX WITH A DARPIN
Descriptor:Tubulin alpha chain, Tubulin beta chain, Designed ankyrin repeat protein (DARPIN) D1, ...
Authors:Pecqueur, L., Gigant, B., Knossow, M.
Deposit date:2012-02-17
Release date:2012-07-11
Last modified:2012-08-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F61
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TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, Stathmin-like domain R4, ...
Authors:Gigant, B., Mignot, I., Knossow, M.
Deposit date:2012-05-14
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (4.17 Å)
Cite:Design and characterization of modular scaffolds for tubulin assembly.
J.Biol.Chem., 287, 2012
4F6R
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TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, Stathmin-like domain R1, ...
Authors:Gigant, B., Mignot, I., Knossow, M.
Deposit date:2012-05-15
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Design and characterization of modular scaffolds for tubulin assembly.
J.Biol.Chem., 287, 2012
4HNA
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KINESIN MOTOR DOMAIN IN THE ADP-MG-ALFX STATE IN COMPLEX WITH TUBULIN AND A DARPIN
Descriptor:Tubulin alpha chain, Tubulin beta chain, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D2, ...
Authors:Gigant, B., Knossow, M.
Deposit date:2012-10-19
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of a kinesin-tubulin complex and implications for kinesin motility.
Nat.Struct.Mol.Biol., 20, 2013
5EYL
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TUBULIN-BINDING DARPIN
Descriptor:DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), PHOSPHATE ION, GLYCEROL
Authors:Ahmad, S., Kossow, M., Gigant, B.
Deposit date:2015-11-25
Release date:2016-07-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
5EYP
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TUBULIN-DARPIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), ...
Authors:Ahmad, S., Knossow, M., Gigant, B.
Deposit date:2015-11-25
Release date:2016-07-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
6GVM
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TUBULIN:F3II DARPIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, STATHMIN-LIKE DOMAIN R1, ...
Authors:Gigant, B., Campanacci, V., Cantos Fernandes, S.
Deposit date:2018-06-21
Release date:2019-04-24
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Insight into microtubule nucleation from tubulin-capping proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
6GVN
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TUBULIN:TM-3 DARPIN COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, TM-3 DARPIN, ...
Authors:Gigant, B., Cantos Fernandes, S., Campanacci, V.
Deposit date:2018-06-21
Release date:2019-04-24
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Insight into microtubule nucleation from tubulin-capping proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
6GX7
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TUBULIN-COPN-ALPHAREP COMPLEX
Descriptor:Tubulin alpha chain, Tubulin beta chain, iiiA5 ALPHAREP, ...
Authors:Gigant, B., Campanacci, V.
Deposit date:2018-06-26
Release date:2019-04-24
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Insight into microtubule nucleation from tubulin-capping proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019