Author results

1OSH
  • Download 1osh
  • View 1osh
Molmil generated image of 1osh
A CHEMICAL, GENETIC, AND STRUCTURAL ANALYSIS OF THE NUCLEAR BILE ACID RECEPTOR FXR
Descriptor:Bile acid receptor, METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE
Authors:Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.-L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G.A., Noel, J.P., Nicolaou, K.C., Evans, R.M.
Deposit date:2003-03-19
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
Mol.Cell, 11, 2003
5U3Q
  • Download 5u3q
  • View 5u3q
Molmil generated image of 5u3q
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 1
Descriptor:Peroxisome proliferator-activated receptor delta, 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(propan-2-yl)amino]methyl}phenoxy)hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3R
  • Download 5u3r
  • View 5u3r
Molmil generated image of 5u3r
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 2
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-[2-({[4-(furan-2-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3S
  • Download 5u3s
  • View 5u3s
Molmil generated image of 5u3s
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 3
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({[4-(furan-3-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3T
  • Download 5u3t
  • View 5u3t
Molmil generated image of 5u3t
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 4
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({(propan-2-yl)[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3U
  • Download 5u3u
  • View 5u3u
Molmil generated image of 5u3u
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 5
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({cyclopentyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3V
  • Download 5u3v
  • View 5u3v
Molmil generated image of 5u3v
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 6
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-[2-({cyclopentyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3W
  • Download 5u3w
  • View 5u3w
Molmil generated image of 5u3w
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 7
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(cyclopropyl)amino]methyl}phenoxy)hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3X
  • Download 5u3x
  • View 5u3x
Molmil generated image of 5u3x
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 8
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({cyclopropyl[4-(pyridin-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3Y
  • Download 5u3y
  • View 5u3y
Molmil generated image of 5u3y
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 9
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-[2-({cyclopropyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U3Z
  • Download 5u3z
  • View 5u3z
Molmil generated image of 5u3z
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 10
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({cyclopropyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U40
  • Download 5u40
  • View 5u40
Molmil generated image of 5u40
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 15
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({benzyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, DI(HYDROXYETHYL)ETHER, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U41
  • Download 5u41
  • View 5u41
Molmil generated image of 5u41
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 16
Descriptor:Peroxisome proliferator-activated receptor delta, 6-[2-({benzyl[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid, DI(HYDROXYETHYL)ETHER, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U42
  • Download 5u42
  • View 5u42
Molmil generated image of 5u42
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 11
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-(2-{[cyclopropyl(3'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U43
  • Download 5u43
  • View 5u43
Molmil generated image of 5u43
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 12
Descriptor:Peroxisome proliferator-activated receptor delta, 6-(2-{[cyclopropyl(4'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U44
  • Download 5u44
  • View 5u44
Molmil generated image of 5u44
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 13
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U45
  • Download 5u45
  • View 5u45
Molmil generated image of 5u45
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH SPECIFIC AGONIST 14
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, 6-(2-{[cyclopropyl(3'-fluoro[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U46
  • Download 5u46
  • View 5u46
Molmil generated image of 5u46
HUMAN PPARDELTA LIGAND-BINDING DOMAIN IN COMPLEXED WITH GW501516
Descriptor:Peroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, S-1,2-PROPANEDIOL, ...
Authors:Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
Deposit date:2016-12-03
Release date:2017-03-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017